Correlation between Leukoaraiosis Volume and Circle of Willis Variants

Saba, Luca; Raz, Eytan; Fatterpekar, Girish M.; Montisci, Roberto; Martino, Michele Di; Bassareo, Pier Paolo; Piga, M.

doi:10.1111/jon.12103

Cited by 16 publications

(10 citation statements)

References 29 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On this basis, Saba et al investigated about any existing relationships between COW variants and LA volume analyzing COW variations and WMH's area by MRI on FLAIR and MRA on TOF sequences. The results confirmed not only a different location of LA distribution volume with predilection for MCA and PCA territories, but also a significant association between more COW existing variants and more WMH's extension areas detected [44]. Bilateral occlusion of carotid artery, detected with CTA, would be determinant to emphasize a perpetual state of inflammation of blood brain barrier, through the activation in loco of MMPs that contribute to brain injury.…”

Section: Discussionsupporting

confidence: 63%

White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance

Garofalo¹,

Suri²,

Porcu³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

White matter disease" identifies a series of different conditions and pathological mechanisms: autoimmune, infectious, toxic-metabolic and vascular. Each of these leads to a global impairment of the neural myelination process through the secondary destruction of previously myelinated structures. To date, the imaging spectrum represents an irreplaceable tool to detect these lesions, describe their distribution patterns and stage them over time.This study aims presents a pictorial review of white matter disease, from pathology to imaging spectrum, reporting current main staging systems with greater emphasis to relationship between cerebrovascular disease and white matter hyper-intensity appearance, and the newest advances in this field.Keywords: CT = Computed Tomography; MRI = Magnetic Resonance Imaging; LA = Leukoaraiosis; WMH = white matter hyperintensities; SVD = small vessels disease; PWMH = periventricular white matter hyperintensities; DWMH = deep white matter hyperintensities Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 5 January 2020

show abstract

Section: Discussionsupporting

confidence: 63%

White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance

Garofalo¹,

Suri²,

Porcu³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our results differ from previous studies that have found an association between incomplete CoW variants and increased WMH load. Most of these studies are on patients with carotid artery stenosis [4,38,39,54]. For this patient group, there is a clear mechanism connecting the CoW anatomy and WMH, i.e., the stenosis will render the collateral capacity of the CoW important for maintaining sufficient blood flow to the brain.…”

Section: Discussionmentioning

confidence: 99%

“…In a convenience sample of 163 patients, it was found that patients with incomplete variants had a significantly higher Fazekas score compared to those with a complete CoW [37]. In patients with carotid artery stenosis, incomplete CoW variants were associated with greater WMH volume and number of WMH lesions [38,39], increased WMH rating [4], and increased deep WMH (DWMH) and periventricular WMH (PWMH) ratings [54]. However, the results are not unison, as some studies fail to find a link between more WMH and decreased completeness of the CoW, both in patients with carotid stenosis [29,45] and in the general population [7].…”

Section: Introductionmentioning

confidence: 95%

An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study

Hindenes

Håberg

Mathiesen

et al. 2021

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…Our results differ from previous studies that have found an association between incomplete CoW variants and increased WMH load. Most of these studies are on patients with carotid artery stenosis (Chuang et al, 2011;Saba et al, 2017Saba et al, , 2015Ye et al, 2019). For this patient group, there is a clear mechanism connecting the CoW anatomy and WMH, i.e., the stenosis will render the collateral capacity of the CoW important for maintaining sufficient blood flow to the brain.…”

Section: Discussionmentioning

confidence: 99%

An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study

Hindenes

Håberg

Mathiesen

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with increased WMH volumes compared to the complete CoW. Methods In a cross-sectional population sample of 1864 people (age 40 - 84 years, 46.4% men), we used an automated method to segment WMH using T1-weighted and T2-weighted fluid-attenuated inversion recovery image obtained at 3T. CoW variants were classified from time-of-flight scans, also at 3T. WMH risk factors, including age, sex, smoking and blood pressure, were obtained from questionnaires and clinical examinations. We used linear regression to examine whether people with incomplete CoW variants had greater volumes of deep WMH (DWMH) and periventricular WMH (PWMH) compared to people with the complete CoW, correcting for WMH risk factors. Results Participants with incomplete CoW variants did not have significantly higher DWMH or PWMH volumes than those with complete CoW when accounting for risk factors. Age, pack-years smoking, and systolic blood pressure were risk factors for increased DWMH and PWMH volume. Diabetes was a unique risk factor for increased PWMH volume. Conclusion Incomplete CoW variants do not appear to be risk factors for WMH in the general population.

show abstract

Correlation between Leukoaraiosis Volume and Circle of Willis Variants

Abstract: The presence and the number of COW variants are associated with a higher leukoaraiosis volume in patients with significant internal carotid artery stenosis.

Cited by 16 publications

References 29 publications

White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance

White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance

An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study

An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study

Contact Info

Product

Resources

About