Correlation between Ion Composition of Oligomineral Water and Calcium Oxalate Crystal Formation

Rossi, Manuela; Barone, Biagio; Domenico, Dante Di; Esposito, Rodolfo; Fabozzi, Antonio; D’Errico, Gerardino; Prezioso, Domenico

doi:10.3390/cryst11121507

Cited by 5 publications

(6 citation statements)

References 43 publications

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“…Furthermore, while research on cystinuria has primarily focused on clinical and genetic aspects to date, considering patient groups without SLC3A1/SLC7A9 mutations, it appears that additional studies are necessary, including research on the physicochemical factors related to cystine aggregation, similar to the results observed in calcium stone studies, and investigations into other urinary tract symptoms that may arise due to cystine crystal formation [34,35].…”

Section: Discussionmentioning

confidence: 99%

Clinical Course and Mutational Analysis of Patients with Cystine Stone: A Single-Center Experience

Jeong,

Oh,

Sohn

et al. 2023

Biomedicines

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Cystinuria is a known genetic disorder. To date, two genes, SLC3A1 and SLC7A9, have been identified as causes of cystinuria. In this study of 10 patients with cystinuria, which is the largest Korean cohort ever studied, we examined the patients’ phenotypes, clinical courses, and genetic analyses. A total of 10 patients with cystinuria diagnosed with cystine stones in a single tertiary medical center (Severance Hospital, Seoul, Republic of Korea) from April 2000 to July 2023 were included in the study. All of the patients participated in mutational studies, and the clinical presentation and consecutive laboratory findings of the patients were analyzed retrospectively. After the initial stone-related surgery or procedure at our hospital, 6 of the 10 patients underwent additional surgery at least once for recurrent stones. Genetic analyses identified six new mutations, of which only two patients had type B mutations. The most common genotype was compound heterozygous type A. We investigated the genotypes and clinical courses of 10 Korean patients with cystinuria who had not been previously reported. More data are needed to statistically analyze the genotype and phenotype of cystinuria.

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Section: Discussionmentioning

confidence: 99%

Clinical Course and Mutational Analysis of Patients with Cystine Stone: A Single-Center Experience

Jeong,

Oh,

Sohn

et al. 2023

Biomedicines

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“…Although the detailed mechanism of the onset of OAB due to hypercalciuria is unclear, a recent report indicated that when hypercalciuria and hyperoxaluria co-exist, fine prenucleation nanoclusters of about 1 nm are formed at first, and the crystals gradually grow, depending on the conditions [ 19 ]. In addition, Rossi et al suggested that the ions/molecules contained in drinking water play an important role in the formation and growth of calcium crystals [ 20 ]. In other words, oligomineral water rich in magnesium (Mg) and sulfate reinforces the structure of water.…”

Section: Discussionmentioning

confidence: 99%

“…They demonstrated its increase of interfacial energy and induction of the formation of large numbers of small crystals. As a result, over time, some crystals, especially calcium crystals, are oriented towards growing, leading to the formation of large crystals and agglomerates of particles [ 20 ]. Furthermore, chronic bladder irritation caused by these crystal components could cause urinary storage symptoms [ 1 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Urinary Calcium Excretion and Lower Urinary Tract Symptoms

et al. 2022

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To date, few detailed studies have been conducted on the convenient and useful markers for the prevalence of lower urinary tract symptoms (LUTS), including overactive bladder (OAB) and nocturia. A high level of calcium (Ca) excretion (hypercalciuria) is indicative of lifestyle-related diseases such as hypertension, which are associated with the onset of LUTS. Hence, in this study we attempted to clarify the relationship between urinary Ca excretion and OAB, nocturia, and nocturnal polyuria in adults. The present study showed that patients with hypercalciuria frequently experienced OAB, nocturia, and nocturnal polyuria. In addition, this study revealed that the severity of LUTS is significantly associated with urinary Ca excretion and that hypercalciuria is an important risk factor for OAB, nocturia, and nocturnal polyuria.

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“…Many dietary components affect calcium absorption, but some mineral waters rich in calcium have absorption efficiency very close to dairy products [ 59 ]. In addition, for children, water with low mineral content is recommended (except in certain specific cases, especially low calcium intakes), but several studies are underway to assess impacts of ion content of drinking water and calcium oxalate crystal formation [ 60 ].…”

Section: Place Of Hydration In Nephrolithiasis Treatmentmentioning

confidence: 99%

Hydration and Nephrolithiasis in Pediatric Populations: Specificities and Current Recommendations

et al. 2023

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Renal lithiasis is less frequent in children than in adults; in pediatrics, lithiasis may be caused by genetic abnormalities, infections, and complex uropathies, but the association of urological and metabolic abnormalities is not uncommon. The aim of this study is to provide a synthesis of nephrolithiasis in children and to emphasize the role of hydration in its treatment. As an etiology is reported in 50% of cases, with a genetic origin in 10 to 20%, it is proposed to systematically perform a complete metabolic assessment after the first stone in a child. Recent data in the field reported increased incidence of pediatric urolithiasis notably for calcium oxalate stones. These changes in the epidemiology of stone components may be attributable to metabolic and environmental factors, where hydration seems to play a crucial role. In case of pediatric urolithiasis, whatever its cause, it is of utmost importance to increase water intake around 2 to 3 L/m2 per day on average. The objective is to obtain a urine density less than 1010 on a dipstick or below 300 mOsm/L, especially with the first morning urine. Some genetic diseases may even require a more active 24 h over-hydration, e.g., primary hyperoxaluria and cystinuria; in such cases naso-gastric tubes or G-tubes may be proposed. Tap water is adapted for children with urolithiasis, with limited ecological impact and low economical cost. For children with low calcium intake, the use of calcium-rich mineral waters may be discussed in some peculiar cases, even in case of urolithiasis. In contrast, sugar-sweetened beverages are not recommended. In conclusion, even if parents and patients sometimes have the feeling that physicians do not propose “fancy” therapeutic drugs, hydration and nutrition remain cornerstones of the management of pediatric urolithiasis.

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Correlation between Ion Composition of Oligomineral Water and Calcium Oxalate Crystal Formation

Cited by 5 publications

References 43 publications

Clinical Course and Mutational Analysis of Patients with Cystine Stone: A Single-Center Experience

Clinical Course and Mutational Analysis of Patients with Cystine Stone: A Single-Center Experience

Relationship between Urinary Calcium Excretion and Lower Urinary Tract Symptoms

Hydration and Nephrolithiasis in Pediatric Populations: Specificities and Current Recommendations

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