Correlation Between Intraocular Pressure, Central Corneal Thickness, Stage of Glaucoma, and Demographic Patient Data

Kniestedt, Christoph; Lin, Shan; Choe, Joyce; Nee, Michelle; Bostrom, Alan; Stürmer, Jörg; Stamper, Robert L.

doi:10.1097/00061198-200604000-00003

Cited by 115 publications

(117 citation statements)

References 29 publications

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“…Similar results, in spite of different mean values, have been reported by previous investigations. 16,[19][20][21][23][24][25][26][27][28][29][30][31]35,36 The DIOP between DCT and GAT readings was higher in healthy than in glaucomatous eyes, either with open-angle or angleclosure phenotypes (Table 1). The same outcome has been found by analysing IOP measurements obtained by DCT and GAT in different groups of subjects with the same CCT value, except for POAG subjects with thinner corneas.…”

Section: Discussionmentioning

confidence: 99%

“…16 DCT was designed to be largely independent of structural properties of the cornea and to eliminate most of the systematic errors arising from physiological variables of the eye, which render GAT less accurate. 17 Some recent studies compared the performance of the new device against other tonometers [18][19][20][21][22] considering either the influence of pachymetry on IOP readings [23][24][25][26] or the impact of refractive surgery as a source of errors in applanation tonometry. [27][28][29][30] Only two studies evaluated ocular structural factors other than pachymetry influencing IOP measurements in healthy subjects 31 or African American subjects.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Goldmann applanation tonometry and dynamic contour tonometry in healthy and glaucomatous eyes

Ceruti

Morbio

Marraffa

et al. 2008

Eye

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Purpose To compare the measurements of intraocular pressure (IOP) with dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) in healthy and glaucomatous eyes and to evaluate the influence of corneal thickness (CCT), corneal curvature (CC), axial length (AL), and age on these tonometric alternatives. Methods Three hundred eyes of 100 healthy subjects, 100 patients with primary open angle glaucoma, and 100 patients with primary angle-closure glaucoma underwent IOP evaluation with DCT and GAT, and measurements of CCT, CC, and AL. Bland-Altman plots were used to evaluate the agreement between tonometers. Regression analysis was used to evaluate the influence of ocular structural factors on IOP measurements obtained with both tonometers. Results Bland-Altman plots indicated that the 95% limits of agreement between tonometers were À1.4 to 6.6 mmHg. DCT values measured 2.6 ± 1.9 mmHg higher than GAT readings (Po0.001). The mean IOP difference between DCT and GAT (DIOP) was higher in healthy than in glaucomatous eyes and the magnitude of difference increased with increasing CCT. A significant reduction of DIOP with an increase in both CCT (Po0.001) and IOP values (Po0.001) was found. Regression analysis showed no effect of CC, AL, and age on both DCT and GAT readings. In contrast to GAT (Po0.001), DCT measurements were not influenced by CCT (P ¼ 0.43).Conclusions IOP readings obtained by DCT were higher and less affected by CCT than those by GAT. The DIOP was higher in healthy than in glaucomatous eyes and decreased in relation to increased CCT and IOP values.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Goldmann applanation tonometry and dynamic contour tonometry in healthy and glaucomatous eyes

Ceruti

Morbio

Marraffa

et al. 2008

Eye

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“…A medida da ECC tornou-se um importante fator biométrico e é parte essencial na propedêutica do glaucoma (3)(4)(5)(11)(12) . Os valores da PIO obtidos com o TCDP em nosso estudo foram maiores que os encontrados com o TAG (3,4,11) .…”

Section: Discussionunclassified

“…A pressão intra-ocular (PIO) é um fator de risco importante no diagnóstico, progressão e tratamento do glaucoma, embora os valores obtidos apresentem uma baixa sensibilidade e uma baixa especificidade (1)(2)(3)(4) . A determinação precisa da PIO é um importante passo na detecção e seguimento do glaucoma, primário ou secundário, bem como no diagnóstico diferencial de glaucoma primário de ângulo aberto, glaucoma de pressão normal e hipertensão ocular (3,5) .…”

Section: Introductionunclassified

“…O tonômetro de aplanação de Goldmann (TAG) é desde então o método mais utilizado ("Gold Standard") para medir a PIO, porém com limitações relacionadas a espessura central da córnea (ECC), curvatura corneana, com a necessidade de instilação tópica de colírio anestésico e colírio de fluoresceína. Atualmente, as propriedades biomecânicas da córnea estão sendo consideradas também como importantes e possíveis fatores relacionados às variações da PIO entre diferentes individuos (2,(4)(5)(6)(7).…”

Section: Introductionunclassified

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Espessura central da córnea e a medida da pressão intra-ocular com diferentes tonômetros

Kitice

Nunes

Giustina

et al. 2007

Rev. bras.oftalmol.

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Ethnic Differences in Trabecular Meshwork Height by Optical Coherence Tomography

et al. 2015

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IMPORTANCE Differences in ocular anatomy may contribute to ethnic differences in glaucoma risk. Because the trabecular meshwork (TM) plays an important role in aqueous outflow, its anatomy in relation to at-risk populations may provide insight into a potential contributor to elevated intraocular pressure and thus to probability of glaucoma development.OBJECTIVE To investigate whether differences exist in TM height between ethnic groups. DESIGN, SETTING, AND PARTICIPANTS This prospective study took place from January 1, 2012, to December 31, 2013. Adult patients who self-reported as being of white, Asian, Hispanic, or African American ethnicity were recruited from ophthalmology clinics at the University of California, San Francisco. The TM height was assessed using spectral-domain anterior segment optical coherence tomography. MAIN OUTCOMES AND MEASURESTrabecular meshwork height was measured from the scleral spur to the Schwalbe line. We hypothesized that ethnicities with a higher prevalence of glaucoma would tend to have shorter TM heights. RESULTSWe collected data from 460 eyes of 291 participants after excluding 34 optical coherence tomographic scans owing to poor image quality. The final sample was 32.2% white, 45.1% Asian, 10.5% African American, and 12.1% Hispanic. There were 64.2% women, and the mean age was 68.1 years. The mean (SD) TM height among all eyes included in the study was 836 (131) μm. The mean (SD) TM height was characterized among white (851 [131] μm), Asian (843 [126] μm), Hispanic (822 [147] μm), and African American (771 [118] μm) persons. Ethnicity was not associated with TM height overall (P = .23, linear mixed regression model). However, the TM heights of African American participants (771 μm) were shorter than those of white (851 μm; adjusted difference 95% CI, -119.8 to -8.1; P = .02) and Asian (843 μm; adjusted difference 95% CI, -117.4 to -10.8; P = .02) participants. CONCLUSIONS AND RELEVANCEAlthough TM height is not associated with ethnicity overall, African American individuals have shorter TM heights compared with Asian and white persons. Trabecular meshwork size may play a role in ethnic differences of glaucoma risk and be a new risk factor to consider in primary open-angle glaucoma.

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Correlation Between Intraocular Pressure, Central Corneal Thickness, Stage of Glaucoma, and Demographic Patient Data

Cited by 115 publications

References 29 publications

Comparison of Goldmann applanation tonometry and dynamic contour tonometry in healthy and glaucomatous eyes

Comparison of Goldmann applanation tonometry and dynamic contour tonometry in healthy and glaucomatous eyes

Espessura central da córnea e a medida da pressão intra-ocular com diferentes tonômetros

Ethnic Differences in Trabecular Meshwork Height by Optical Coherence Tomography

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