Correlation between Interocular Asymmetry of Corneal Hysteresis and Visual Field Defect in Glaucoma

Abstract

Purpose: To evaluate the relationship between interocular asymmetries of corneal hysteresis (CH) and visual field defects in Korean patients with glaucoma.Methods: A total of 444 eyes of 222 participants with glaucoma in at least one eye were enrolled. CH was measured using an ocular response analyzer (Reichert Technologies Inc., Depew, NY, USA). Eyes of each participant were classified into "better eye" and "worse eye" based on the mean deviation (MD) value of visual field test. The correlation between interocular differences in intraocular pressure (IOP), axial length, central corneal thickness (CCT), CH, and MD values was evaluated using Spearman's correlation analysis. To exclude the possible effect of anti-glaucoma medication on corneal properties, additional analyses were performed on eyes without any glaucoma treatment at the time of CH measurement (treatment-naïve group).Results: Median (interquartile range) MD value was -3.71 (-6.87, -1.30) dB in the "better eye" and -10.20 (-16.32, -5.62) dB in the "worse eye". When the correlation between the asymmetry of the MD value and asymmetry of IOP, axial length, CCT, and CH were evaluated, only interocular differences in CH were significantly associated with interocular differences in MD values (correlation coefficient = 0.214, p = 0.001). Among the 222 participants, 60 (27.0%) were treatment-naïve group. In these eyes, interocular differences in CH were also significantly associated with interocular differences in the MD values (correlation coefficient = 0.285, p = 0.029). Conclusion:The interocular asymmetry of CH was significantly correlated with the interocular asymmetry of visual field defects in glaucoma.

In Vivo Biomechanical Response of the Human Cornea to Acoustic Waves

“…The most commonly used approaches involve the use of air-puff tonometry, such as the Ocular Response Analyzer (ORA), which is a noninvasive device that measures the intraocular pressure (IOP) and corneal biomechanics, including corneal hysteresis (CH) and corneal resistance factor (CRF) parameters [9]. The ORA device has been extensively used to explore the impact of corneal biomechanics on myopia development [10], asymmetry of visual field defects in glaucoma [11], the effect of soft contact lens use in healthy subjects [12], or corneal changes due to degenerative keratoconus disease [13].…”