Correlation between innate and adaptive immunity response in TB children post BCG vaccination. Is it effective or not?: Cross-sectional study

Shabariah, Rahmini; Farsida,; Hatta, Mochammad; Patellongi, Ilhamjaya; M.Kes, Irfan Idris; Santoso, Arif; Islam, Andi Asadul; Natzir, Rosdiana; Wahyudin, Bob; Warsinggih,; Sanjoyo,

doi:10.1016/j.amsu.2022.103586

Cited by 2 publications

(4 citation statements)

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“…Our study reported more than half (58.8%) of the respondents had BCG scars, this is consistent with another study outside Nigeria, where most (68.1%) subjects with TB who had been vaccinated with BCG had BCG scars [5]. Usually when children are vaccinated with BCG a scar usually forms from a papule with induration which appears at the site of intradermal administration of BCG [2,[29][30][31][32].…”

Section: Discussionsupporting

confidence: 90%

“…The role of CD4+ T cells in immunity against tuberculosis (TB) have been widely acknowledged [1][2][3][4][5]. Whether as a result of natural TB infection or due to vaccination with bacille Calmette-in HIV TB coinfection [10].…”

Section: Introduction Backgroundmentioning

confidence: 99%

“…BCG protection wanes with age, the duration of protection after neonatal BCG vaccination could last between 10 to 20 years, however, one study reported up to 50-60 years protection against all TB outcomes following neonatal BCG vaccination [2,[25][26][27][28][29]. CD4+ cells also play a role in BCG induced immunity against TB [5,[13][14][15].…”

Section: Introduction Backgroundmentioning

confidence: 99%

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Percentage and Absolute CD4+ Count and Factors Influencing Their Levels in Tuberculosis Patients in a Tetiary Hospital, Kaduna, Nigeria

Suzie,

Mohammed

2023

J Pulmonol Res Rep

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Background: The role of CD4+ T cells in immunity against tuberculosis have been widely acknowledged. This study determined CD4+ absolute, CD4 percentage and haemoglobin (HB) levels in tuberculosis (TB) patients undergoing TB treatment and compared these levels with presence of some factors which could modify the quantities of CD4+, CD4% and HB in TB patients. Methods: A cross-sectional study of eighty-five persons attending TB DOTS clinic in tertiary hospital between 2020 to 2021. Multicolour fluorescence imaging and absorbance spectrometry microscopy was used to enumerate CD4+ absolute count, CD4+ percentage and HB concentration in whole blood. Questionnaire and interviews were used to determine history, demographic data, BCG vaccination, BCG scar, vitamin A supplementation, awareness of zoonotic diseases and zoonotic TB, maternal BCG vaccination status, maternal BCG scar and undernutrition for each respondent. Results: CD4% significantly differed between forty-seven males (mean age: 33.5) and thirty-eight females (mean age: 32.2) (p <0.05). T-test indicated no significant difference in CD4+ count, CD4% and HB compared with BCG vaccination status, presence of BCG scar, knowledge of zoonotic diseases, knowledge of zoonotic TB and with vitamin A supplementation (p <0.05). There was also significant difference in CD4% compared with undernutrition and in absolute CD4+ counts compared with drug resistance (p <0.05). Conversely, there was significant difference in CD4% and absolute CD4+ count when compared with maternal BCG vaccination, presence of maternal BCG Scar. Pearson correlation coefficient indicated weak negative relationship between CD4%, absolute CD4+ count and age. Also, weak positive relationship between HB and age. Both relationships were not significant (p <0.05). Conclusion: Undernutrition, gender, maternal BCG vaccination (with or without scaring) and age influence levels of CD4+ in TB patients.

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Section: Discussionsupporting

confidence: 90%

Section: Introduction Backgroundmentioning

confidence: 99%

Section: Introduction Backgroundmentioning

confidence: 99%

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Percentage and Absolute CD4+ Count and Factors Influencing Their Levels in Tuberculosis Patients in a Tetiary Hospital, Kaduna, Nigeria

Suzie,

Mohammed

2023

J Pulmonol Res Rep

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“…52 In this research, the TLR2 gene expression from the newborns and the LTBI pregnant women increased 1.2 times than their non-LTBI counterpart. This result is in line with previous studies where it was reported that TLR2 is the very rst in ammation mediator that plays the role during M. tuberculosis infection and lung TB risk factors 53,54,55 but the aforementioned results were different from this one study in India. 56 Despite TLR2 testing not conducted on LTBI pregnant women, but based on previous results, the natural immune response component from LTBI pregnant women that appears during pregnancy will enter the fetus through the placenta, so we would expect more TLR2 gene expressions on newborns compared to the pregnant women.…”

Section: Discussionsupporting

confidence: 87%

Correlation Between Vitamin D Levels on Pregnant Women With Latent Tuberculosis Infection and Vitamin D Levels, Cathelicidin, Interferon γ, and Tlr2 Expression on Neonates in Medan, North Sumatera, Indonesia

Meirina

Sari

Lubis

et al. 2023

Preprint

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Background: Latent Tuberculosis Infection (LTBI) on pregnant women are highly prone to progress into an active TB infection that could infect her newborn. The aforementioned progressivity is dependent on the mother’s immunity system, and said immune system’s mechanism is influenced by the levels of vitamin D. The immune response on pregnant mother during the infection process is thought to affect the child’s immune system since the pregnancy term. The purpose of this research is to find the role of vitamin D levels on LTBI pregnant women on the vitamin D level and immune response of the neonates so that we are able to pinpoint and create an adequate immune system for both the children and mothers with LTBI since fetal period as a TB prevention effort on neonates Patients and Methods: This study utilized the case control design that included 84 pregnant women on their third trimester of pregnancy, as well as their children from three hospitals in Medan, North Sumatera. The subject of this study is 42 LTBI pregnant women (IGRA-positive) and 42 non-LTBI pregnant women (IGRA-negative) and their neonates. This study was conducted from December 2021 until July 2022. The measured parameters were vitamin D levels, cathelicidin, and IFNg on the pregnant women that would be correlated with the newborn’s vitamin D levels, cathelicidin, IFNg, and TLR2. Further analysis for this study utilized the Chi-squared test and the Fisher test, and for Spearman’s correlation was used for correlation testing. Results: The study’s result reported that LTBI pregnant women are at risk for vitamin D insufficiency (OR = 3.667, p = 0.006) and plays a role on their newborn’s vitamin D levels (p = 0.038). The vitamin D levels on LTBI pregnant women and the vitamin D levels on healthy newborns from LTBI pregnant women is significantly correlated with the newborns’ TLR2 levels (p = 0.048; p = 0.005). The higher levels of vitamin D on newborns with non-LTBI pregnant women plays a role on their newborn’s cathelicidin (p = 0.043). The cathelicidin and IFNg levels on pregnant woman with LTBI plays a role on their newborn’s cathelicidin and IFNg levels (p = 0.03; p = 0.001). The vitamin D levels on LTBI pregnant women plays a role on their newborn’s vitamin D levels. Cathelicidin, IFNg, and TLR2 level on newborns are influenced by the mother’s immune response and the newborn’s vitamin D levels itself.

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Correlation between innate and adaptive immunity response in TB children post BCG vaccination. Is it effective or not?: Cross-sectional study

Cited by 2 publications

References 65 publications

Percentage and Absolute CD4+ Count and Factors Influencing Their Levels in Tuberculosis Patients in a Tetiary Hospital, Kaduna, Nigeria

Percentage and Absolute CD4+ Count and Factors Influencing Their Levels in Tuberculosis Patients in a Tetiary Hospital, Kaduna, Nigeria

Correlation Between Vitamin D Levels on Pregnant Women With Latent Tuberculosis Infection and Vitamin D Levels, Cathelicidin, Interferon γ, and Tlr2 Expression on Neonates in Medan, North Sumatera, Indonesia

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