Correlation between inflammatory markers and insulin resistance in pregnancy

Korkmazer, Engin; Solak, Neşe

doi:10.3109/01443615.2014.948408

Cited by 31 publications

(27 citation statements)

References 25 publications

(16 reference statements)

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“…Our results are consistent with Retnakaran et al who demonstrated obesity during pregnancy elicits an inflammatory response with possible downstream metabolic sequelae including insulin resistance [41]. Similarly, Korkmazer et al found higher inflammation among insulin resistant pregnant women with and without a classification of gestational diabetes [42]. The clinical implications of this could be substantial as the combination of obesity and insulin resistance during pregnancy can lead to gestational diabetes [13].…”

Section: Discussionsupporting

confidence: 90%

Altered maternal lipid metabolism is associated with higher inflammation in obese women during late pregnancy

Tinius¹,

Cahill²,

Strand³

et al. 2016

Integr Obesity Diabetes

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Inflammation is elevated in obese pregnant women and is associated with adverse maternal and neonatal outcomes. Maternal lipid metabolism and its relationships with maternal inflammation, insulin resistance and neonatal metabolic health are poorly understood in obese pregnant women. 18 lean (age: 26.1 ± 5.0 years, pre-pregnancy BMI: 21.5 ± 1.9 kg/m2) and 16 obese (age: 25.0 ± 4.8 years, pre-pregnancy BMI: 36.3 ± 4.3 kg/m2) women participated in this case-control study during the third trimester of pregnancy. Maternal plasma markers of insulin resistance (HOMA-IR) and inflammation (C-reactive protein (CRP)) were measured at rest, and lipid concentration and kinetics (lipid oxidation rate and lipolysis) were measured at rest, during a 30-minute bout of low-intensity (40% VO2peak) exercise, and during a recovery period. Umbilical cord blood was collected for measurement of neonatal plasma insulin sensitivity, inflammation, and lipid concentration. Neonatal body composition was measured via air displacement plethysmography. Pregnant obese women had higher plasma CRP (9.1 ± 4.0 mg/L versus 2.3 ± 1.8 mg/L, p<0.001) and higher HOMA-IR (3.8 ± 1.9 versus 2.3 ± 1.5, p=0.009) compared to pregnant lean women. Obese women had higher lipid oxidation rates during recovery from low-intensity exercise (0.13 ± 0.03 g/min versus 0.11 ±0.04 g/min, p=0.02) that was associated with higher maternal CRP (r=0.55, p=0.001). Maternal CRP was positively associated with maternal HOMA-IR (r=0.40, p<0.02) and systolic blood pressure (r=0.40, p<0.02). Maternal lipid metabolism-associated inflammation may contribute to insulin resistance and higher blood pressure in obese women during pregnancy.

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Section: Discussionsupporting

confidence: 90%

Altered maternal lipid metabolism is associated with higher inflammation in obese women during late pregnancy

Tinius¹,

Cahill²,

Strand³

et al. 2016

Integr Obesity Diabetes

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“…Maternal peripheral insulin resistance, low grade inflammation, and oxidative stress are central features of GDM . A key strength of this study is the combined use of in vitro and in vivo models to investigate the ability of naringenin to disrupt pathways known to GDM pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

“…Insulin resistance is a central feature of GDM. There is extensive evidence to suggest that low‐grade maternal inflammation contributes to the peripheral insulin resistance characteristic of GDM . Several studies have demonstrated that pro‐inflammatory mediators, such as TNF, and pathogenic factors, such as bacterial and viral products, can induce defects within the insulin signaling pathway in skeletal muscle .…”

Section: Discussionmentioning

confidence: 99%

“…Low‐grade maternal inflammation is also associated with GDM, with several studies demonstrating increased presence of circulating pro‐inflammatory mediators in women with GDM . The pro‐inflammatory cytokine TNF, which is increased in women with GDM is positively associated with insulin resistance in pregnancy, and increases in CXCL8 and CCL2 markers of inflammation in both placenta and adipose tissue . Thus, this study sought to determine if naringenin could reduce inflammation in placenta and adipose tissue in human tissues and in GDM mice.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti‐Diabetic, Anti‐Inflammatory, and Anti‐Oxidant Effects of Naringenin in an In Vitro Human Model and an In Vivo Murine Model of Gestational Diabetes Mellitus

Nguyen-Ngo

Willcox

Lappas

2019

Molecular Nutrition Food Res

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Scope Gestational diabetes mellitus (GDM), which affects up to 20% of pregnant women, is associated with maternal peripheral insulin resistance, low‐grade inflammation, and oxidative stress. The flavonoid naringenin has potent anti‐diabetic, anti‐inflammatory, and anti‐oxidative properties; however, its effects in GDM remain unknown. The study aimed to determine the effects of naringenin on glucose metabolism, inflammation, and oxidative stress associated with GDM both in vitro and in vivo. Methods and results In vitro, human tissue samples obtained at term elective Caesarean section are stimulated with tumour necrosis factor alpha (TNF) to develop a GDM‐like environment. Naringenin treatment significantly improves TNF‐impaired glucose uptake in skeletal muscle. In placenta and visceral adipose tissue (VAT), naringenin significantly reduces expression of pro‐inflammatory cytokines and chemokines and increases antioxidant mRNA expression. Mechanistically, naringenin suppresses nuclear factor κB activation. In vivo, pregnant heterozygous db/+ mice are used to model GDM. Daily intraperitoneal injections of GDM mice with naringenin from gestational day 10–17 significantly improve glucose tolerance, reduces IL1A mRNA expression, and increases antioxidant mRNA expression in placenta, VAT, and subcutaneous adipose tissue. Conclusion Naringenin is shown to improve insulin sensitivity, inflammation, and oxidative stress associated with GDM and shows promise as a novel preventive therapeutic.

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“…Taking these results together, higher level of CG decreased the expression of insulin-responsive genes and reduced insulin-stimulated glucose uptake in 3T3-L1 adipocytes, which indicated that CG may impair insulin sensitivity in vivo to induce the development of GDM, in view of higher CG in pregnancy and GDM. Inflammation in pregnancy is correlated with IR in GDM (Wolf et al 2004, Korkmazer & Solak 2014. As inflammatory cytokines, such as TNF-a (Hotamisligil et al 1993), IL6 (Rotter et al 2003) and PAI1 (Shimomura et al 1996) and chemokines such as MCP1 (Sartipy & Loskutoff 2003, Kanda et al 2006 are expressed in adipose tissue, we further assessed changes in cytokine expression after incubation 3T3-L1 adipocytes with CG.…”

Section: Discussionmentioning

confidence: 99%

High levels of chorionic gonadotrophin attenuate insulin sensitivity and promote inflammation in adipocytes

Fan

Wang

et al. 2015

Journal of Molecular Endocrinology

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Gestational diabetes mellitus (GDM) presents with moderate inflammation, insulin resistance and impaired glucose uptake, which may result from increased maternal fat mass and increased circulation of placental hormones and adipokines. In this study, we set out to test whether the surge in chorionic gonadotrophin (CG) secretion is a cause of inflammation and impaired insulin sensitivity in GDM. We first found that LH/chorionic gonadotrophin receptors (CG/LHR) were expressed at low levels in insulin-sensitive murine 3T3-L1 adipocytes and murine C2C12 myocytes. CG treatment not only directly reduced insulin-responsive gene expression, including that of glucose transporter 4 (GLUT4), but also impaired insulin-stimulated glucose uptake in 3T3-L1 cells. Moreover, CG treatment increased the expression of the proinflammatory cytokine monocyte chemotactic protein 1 (MCP1) and upregulated nuclear factor k-light-chain-enhancer of activated B cells (NF-kB) activity in 3T3-L1 cells. Clinically, pregnant women who had higher CG levels and elevated MCP1 developed GDM. Above all, apart from prepregnancy BMI and MCP1 level, CG level was associated with abnormal glucose tolerance. In summary, our findings confirmed that higher CG levels in pregnancy possibly played a role in GDM development partly by impairing the functions of insulin, such those involved in as glucose uptake, while promoting inflammation in adipocyte.

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Correlation between inflammatory markers and insulin resistance in pregnancy

Cited by 31 publications

References 25 publications

Altered maternal lipid metabolism is associated with higher inflammation in obese women during late pregnancy

Altered maternal lipid metabolism is associated with higher inflammation in obese women during late pregnancy

Anti‐Diabetic, Anti‐Inflammatory, and Anti‐Oxidant Effects of Naringenin in an In Vitro Human Model and an In Vivo Murine Model of Gestational Diabetes Mellitus

High levels of chorionic gonadotrophin attenuate insulin sensitivity and promote inflammation in adipocytes

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