Correlation between Inflammatory Marker and Glycemic Control in Patients with Ischemic Heart Disease

Abstract

Background: Recent evidence suggests that inflammatory markers and poor glycemic control are significantly associated with the development of cardiovascular complications. The purpose of this study was to determine the association between inflammatory marker (CRP) and glycemic status (HbA1c) in ischemic heart disease patients.
 Method: This cross sectional study was performed on 668 patients of ischemic heart disease in the Department of Cardiology, Dhaka Medical College Hospital, Dhaka, who underwent Coronary angiogram from January 2017 to December 2017. CRP value were divided into normal (<6 mg/L), borderline (6-10 mg/L) and high (>10 mg/L) and HbA1c was divided <6.5% and ≥6.5%. After performed Coronary angiography the extent of disease was divided into insignificant CAD of (<50% stenosis), significant CAD considered as >50% stenosis and single vessel, double vessel, triple vessel CAD and normal coronaries. The relationship between CRP with HbA1c was analyzed by Chi square test. ANOVA test was used to analyze the continuous variables, shown with mean and standard deviation. Pearson’s correlation coefficient was used to test the relationship between CRP and HbA1c in CAD patients. p value <0.05 was considered as statistically significant.
 Result: Most (65.0%) of the patients belonged to age 41-60 years. The mean age was found 51.4±10.7 years. Majority (82.3%) of patients were male. Among risk factors, highest (40.0%) patients had hypertension followed by 209 (31.3%) diabetes mellitus and 204 (30.5%) smoker. Positive correlation was found (r=0.220, p= 0.001) between HbA1c with CRP in CAD patients. High CRP was found 138(38.4%) in <6.5% HbA1c and 187(60.5%) in ≥6.5 percent HbA1c. The difference was statistically significant (p<0.05). Multi variable logistic regression was found high HbA1c, high CRP and diabetes mellitus were statistically significant (p<0.05) in severe CAD (Double and triple vessel) patient.
 Conclusion: Positive correlation was found between serum levels of CRP and HbA1c in CAD patients. Thus, aiming at good glycemic control and estimation of serum CRP levels will possibly be of help in planning early intervention, thereby preventing further complications which in turn may help preserve cardiac functions in ischemic heart disease patients.
 Bangladesh Heart Journal 2018; 33(2) : 100-105

Study to determine between HbA1C and C-reactive protein in Diabetes mellitus

“…The mean age was found (53.0%±13) years with a range from 19-84 years, significantly higher than the control group. In a similar report, Muhammad et al 12 found that the mean age of the study population was 51.5±9.5 years.The majority (65.6%) of the patients were female (65.7%) in the present study which is in concordance with Muhammad et al 11 The present study suggests that the association between CRP and diabetes risk was stronger in women than in men, which is similar to the Huet al 13 and Pichandi, et al 14 and discordance to Ahemed et al 15 Gender differences in plasma CRP are well documented, with circulating levels being higher in women. [16][17][18] This difference is not fully understood but could be related to gender differences in both visceral and subcutaneous fat, an important factor in CRP levels 18 or to differences in estrogen, which is known to increase CRP level.…”