Correlation between induction of the mac25 gene and anti-proliferative effects of 1α,25(OH)2-D3 on breast cancer and leukemic cells

Kanemitsu, Noriyuki; Kato, Mitsuo; Bai, Fulu; Miki, Tsuneharu; Inoue, Toshiaki; Sakai, Toshiyuki

doi:10.3892/ijmm.7.5.515

Cited by 4 publications

(3 citation statements)

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“…Many factors, including cortisol (Pereira et al 1999), retinoic acid (Swisshelm et al 1995), IGF-I (Hwa et al 1998), transforming growth factor-b (Hwa et al 1998), 1a25(OH)2-D3 (Kanemitsu et al 2001) and parathyroid hormone (Pereira & Canalis 1999), have been demonstrated to be capable of enhancing the expression of IGFBP-rP1. These results suggest that IGFBP-rP1 expression change may be caused by abnormalities in upstream regulators.…”

Section: Discussionmentioning

confidence: 99%

Detection of the differentially expressed gene IGF-binding protein-related protein-1 and analysis of its relationship to fasting glucose in Chinese colorectal cancer patients.

Shao

Huang

Luo

et al. 2004

Endocr Relat Cancer

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IGF-binding protein-related protein-1 (IGFBP-rP1) is a member of the IGF axis. In our previous work, we separated cDNA fragments of IGFBP-rP1 from colonic adenocarcinoma and normal mucosa cDNA subtraction libraries. In this study, we compared the expression of IGFBP-rP1 by semi-quantitative RT-PCR and immunohistochemistry among colorectal cancer, adenoma, normal tissue adjacent to cancer site, and normal tissue. Associations between IGFBP-rP1 and plasma glucose were further explored. We found that the mRNA level of IGFBP-rP1 was highest in cancer, moderate in adenoma and tissue adjacent to the cancer site and lowest in normal tissue ðP < 0:05Þ. A significant difference was found in the immunoreactivity of IGFBP-rP1 between paired normal and cancer tissue ðP < 0:05Þ. Tumor samples with upregulated expression of IGFBP-rP1 in invading tumor cells showed an increased frequency of metastasis to the lymph node, an increased depth of infiltration and stronger staining of IGFBP-rP1 compared with other samples ðP < 0:05Þ. The fasting glucose level was significantly correlated with the staining of IGFBP-rP1 in cancer tissue (Spearman's rho = 0.4, P < 0.000). Thus, we concluded overexpression of IGFBP-rP1 might play an important role in the initiation and promotion of colorectal cancer. IGFBP-rP1 expression may also be associated with fasting glucose level and the presence of diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Detection of the differentially expressed gene IGF-binding protein-related protein-1 and analysis of its relationship to fasting glucose in Chinese colorectal cancer patients.

Shao

Huang

Luo

et al. 2004

Endocr Relat Cancer

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“…34,35 The other secreted protein Igfbp7 is a major factor upregulated during U937 differentiation by vitamin D3 treatment, as the cells undergo growth arrest. 44 A decrease in Igfbp7 is also associated with tumorigenesis in an in vivo mouse tumor model. 45 Thus, the decreased expression of these growth inhibitory proteins is in agreement with the increased growth observed in the AML1-ETO9a-expressing cells.…”

Section: Discussionmentioning

confidence: 99%

The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation

Wang

et al. 2007

Leukemia

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The 8;21 translocation is a common chromosomal abnormality in acute myeloid leukemia (AML). We recently identified a naturally occurring leukemogenic splice variant, AML1-ETO9a (acute myeloid leukemia-1 transcription factor and the eighttwenty-one corepressor-9a), of t(8;21). To understand the leukemic potential of AML1-ETO9a, we performed microarray analysis with the murine multipotential hematopoietic FDCPmix A4 cell line. We identified changes in expression of various genes including CD44. CD44 is a type I transmembrane protein and functions as the major cellular adhesion molecule for hyaluronic acid, a component of the extracellular matrix. CD44 is expressed in most human cell types and is implicated in myeloid leukemia pathogenesis. We show that the presence of AML1-ETO9a significantly increased the expression of CD44 at both RNA and protein levels. Furthermore, the CD44 promoter is bound by AML1-ETO9a and AML1-ETO at the chromatin level. In addition, in the AML1-ETO9a leukemia mouse model CD44 is regulated in a cell context-dependent manner. Thus, our observations suggest that AML1-ETO and its splice variant AML1-ETO9a are able to regulate the expression of the CD44 gene, linking the 8;21 translocation to the regulation of a cell adhesion molecule that is involved in the growth and maintenance of the AML blast/stem cells.

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“…A few of the other genes that are regulated by 1,25(OH) 2 D3 are BRCA1, early growth response gene-1, MAPK, and insulinlike growth factor-binding protein [14][15][16][17][18]. Furthermore, C/EBP␤ and Rb are up-regulated as HL60 myeloblasts differentiate to macrophages when cultured with 1,25(OH) 2 D3.…”

Section: Molecualr Targets Of 125(oh) 2 D3mentioning

confidence: 94%

Vitamin D compounds in leukemia

Luong

Koeffler

2005

The Journal of Steroid Biochemistry and Molecular Biology

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Correlation between induction of the mac25 gene and anti-proliferative effects of 1α,25(OH)2-D3 on breast cancer and leukemic cells

Cited by 4 publications

References 0 publications

Detection of the differentially expressed gene IGF-binding protein-related protein-1 and analysis of its relationship to fasting glucose in Chinese colorectal cancer patients.

Detection of the differentially expressed gene IGF-binding protein-related protein-1 and analysis of its relationship to fasting glucose in Chinese colorectal cancer patients.

The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation

Vitamin D compounds in leukemia

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