Correlation between immunologic responsiveness to haptens and stimulation of stem cell migration by immunization with hapten-carrier conjugates

Khaitov, R. M.; Kozhinova, E. V.; Alekseeva, N. Yu.; Filatova, E. D.

doi:10.1007/bf00830356

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…It is noteworthy that TPS tended to increase in [5,7,8]. On the other hand, the C57B1/6 strain is characterized by a higher immunoreactivity to a number of viral infections and by increased interferon production as compared to the BALB/c strain [1].…”

Section: Resultsmentioning

confidence: 99%

Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation

et al. 1995

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A hypothesis about a correlation between threshold pain sensitivity and antibody production is proposed and experimentally validated. Immunodeficient mouse strains are characterized by a higher threshold sensitivity to pain than animals with a normal immune response. A highly reliable negative correlation between threshold sensitivity to pain assessed by the hot plate test and the number of antibody-producing cells in the spleen after immunization with sheep red cells is observed in 77% of (CBAxC57B1/ 6) F 1 mice examined. The negative correlation is observed both in spontaneous variations of threshold pain sensitivity and during an elevation of this threshold under the effect of preceding nociceptive stimulation.

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Section: Resultsmentioning

confidence: 99%

Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation

et al. 1995

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“…For permission to copy go to https://www.oceansidepubl.com/permission.htm tion is probably due to polycation effect that enhances migration and cooperation of immunocompetent cells during the immune response. 46 Considering the immunological features of polyampholytes, it is not surprising that we could not observe enhanced IgG antibody formation to OA when we used the C-2 complex, as well as more stable C-3 complex.…”

Section: Oamentioning

confidence: 89%

Modified Allergen Immunotherapy: Effect on Immunoglobulin E Production

Babakhin¹,

Хаитов²,

Петров³

1995

allergy asthma proc

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New forms of allergen immunotherapy are proposed employing modified allergens that induce T-cell responses without associated increased IgE-related responses. Synthetic polyelectrolytes attached to an analyte may modulate T-and 8-cellfunction, producing effective desensitization and altering immunoglobulin production dependent on the physico-chemical nature of the carrier molecule. (Allergy Proc 16, 4:195-202, 1995) S pecific hyposensitivity or specific immunotherapy for treatment of Type I hypersensitivity was first applied as oral allergen immunotherapy by Curtis] and as subcutaneous immunotherapy by Noon and Freeman.2,3 Since then, immunotherapy has been used extensively and represents the only allergen-specific treatment of allergic diseases. The clinical efficacy of immunotherapy treatment protocols has been documented in a number of studies involving rhinitis and asthma patients, although asthma, because of the multifactorial pathophysiology involved, may not respond as satisfactorily as rhinitis to immunotherapy.4 Immunotherapy is inappropriate for food allergy and is not indicated for eczema, urticaria, or angioedema.The primary clinical goal of specific immunotherapy is to reduce the patient's immune response-related symptoms to a given allergen. Although the mechanisms of immunotherapy are still poorly understood, successful specific immunotherapy generally results in the follow- Russian Federal Institute of Immunology and Academy of Sciences of Russia, Moscow Address correspondence and reprint requests to AlexanderAllergy Proc.ing: 1) reduction of both polyclonal and allergen-specific 19B; 2) increase of allergen specific "blocking" 19B antibodies; 3) reduction of mediator release from basophil and mast cells; 4) suppression of late phase reactions by inhibiting recruitment of inflammatory cells; 5) decrease of proliferative response and Iymphokine production upon allergen challenge; 6) generation of allergenspecific suppressor cells; and 7) inhibition of IL-4 production and/or enhancement of IFN-'Y production by allergen specific T-cells. Immunotherapy initially produces an increase in specific 19B in the serum, although longer treatment often results in a decline of specific 19B levels.The inhibition of allergic reactivity is the primary goal of immunotherapy, and the changing of antibody production to allergen from 19B to other isotypes may play an important role in successful immunotherapy. Clinical efficacy of immunotherapy may be improved and the risk of side effects reduced by the use of modified allergens.Thus, the suppression of 19B response could be achieved by inoculation of allergen-autologous antibody complexes,5-7 or the combination of passive and active immunization. 8 Alternatively, simultaneous administration of allergens with immunosuppressive agents such as cyclosporin A may enhance induction of specific nomesponsiveness,9In previous years, various attempts have been made to improve specific immunotherapy, These approaches included: 1) varying the modes of administration; 2) stan...

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Correlation between immunologic responsiveness to haptens and stimulation of stem cell migration by immunization with hapten-carrier conjugates

Cited by 2 publications

References 6 publications

Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation

Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation

Modified Allergen Immunotherapy: Effect on Immunoglobulin E Production

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