Correlation between immunohistochemical expression of Ki-67and P63 and aggressiveness of urinary bladder urothelial carcinoma

Abdallah, Magda A.; Wahbbah, Mahmoud Ahmed; Selem, Mohamed; Abdou, Asmaa Gaber; Sultan, Sultan M

doi:10.1080/15321819.2020.1844752

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…According to Compérat et al, consistently different P63 expression rates can be detected in low- vs. high-grade, as well as low- vs. high-stage bladder tumors, with lower-grade and -stage tumors showing more intense and homogeneous staining [ 22 ], as confirmed by a later study [ 23 ]. Such findings support the role of P63 assessment in the differential diagnosis of low- and high-grade NMIBCs, along with its gradual decrease over disease progression.…”

Section: Discussionmentioning

confidence: 87%

Prognostic Value of P63 Expression in Muscle-Invasive Bladder Cancer and Association with Molecular Subtypes—Preliminary Report

Sanguedolce,

Falagario,

Zanelli

et al. 2024

CIMB

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There is an ongoing need for biomarkers that could reliably predict the outcome of BC and that could guide the management of this disease. In this setting, we aimed to explore the prognostic value of the transcription factor P63 in patients with muscle-invasive bladder cancer (MIBC) having undergone radical cystectomy. The correlation between P63 expression and clinicopathological features (tumor stage, nodes involvement, patterns of muscularis propria invasion, papillary architecture, anaplasia, concomitant carcinoma in situ, lymphovascular invasion, perineural invasion, necrosis) and molecular subtyping (basal and luminal type tumors) was tested in 65 radical cystectomy specimens and matched with cancer-specific survival (CSS) and overall survival (OS). P63-negative tumors displayed significantly higher rates of pattern 2 of muscularis propria invasion (50% vs. 14%, p = 0.002) and variant histology (45% vs. 19%, p = 0.022) compared to P63-positive ones. According to the combined expression of CK5/6 and CK20 (Algorithm #1), P63-positive and P63-negative tumors were mostly basal-like and double-negative, respectively (p = 0.004). Using Algorithm #2, based on the combined expression of CK5/6 and GATA3, the vast majority of tumors were luminal overall and in each group (p = 0.003). There was no significant difference in CSS and OS between P63-positive and P63-negative tumors, but the former featured a trend towards longer OS. Though associated with pathological features harboring negative prognostic potential, P63 status as such failed to predict CSS and OS. That said, it may contribute to better molecular subtyping of MIBC.

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Section: Discussionmentioning

confidence: 87%

Prognostic Value of P63 Expression in Muscle-Invasive Bladder Cancer and Association with Molecular Subtypes—Preliminary Report

Sanguedolce,

Falagario,

Zanelli

et al. 2024

CIMB

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“…MUC1, MUC2, MUC5AC and MUC6 and other members of the mucins family, have been indicated as havingclosed association between aberrant mucin expression and aggressive behaviors of malignancies [ 50 , 51 ]. P63 could help in the identification of bladder tumors with squamous differentiation, and a high percentage of p63 immunoexpression showed a significant association with low-grade urothelial carcinoma [ 52 ]. For a specific marker, current studies have found that NANOG and GATA3 are sensitive markers for urothelial carcinoma, and might be a potential biomarker for early diagnosis of urothelial carcinoma [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review

Tian

Tao

et al. 2023

Medicina

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Primary urethral adenocarcinoma in females is an extremely rare malignancy with unclear origin and only a few retrospective cases have been reported. The controversy continues to exist over the origin of primary urethral adenocarcinoma from periurethral glands (which include the Skene’s glands), urethritis glandularis or intestinal metaplasia. Herein, we report one case of a 49-year-old female with distal urethral adenocarcinoma who presented with obstructive voiding. Abdominal and pelvic CT scans and chest radiology were unremarkable. Biopsy of the mass confirmed urethral adenocarcinoma. The patient underwent partial ureterectomy and was disease-free at the 2-years follow-up period. We also present another extremely rare case of primary urethral adenocarcinoma with mucinous features in a 58-year-old female who initially complained of external urethral orifice itching with painless urethral bleeding and was treated with local excision. The patient has not received any neoadjuvant or adjuvant therapy, and experienced tumor recurrence, inguinal lymph nodes metastasis, and even local iliopsoas metastasis during over 10-years follow-up. In conclusion, our current study emphasizes the importance of imaging studies and biopsy in making an accurate preoperative diagnosis of this rare disease, and further highlights the role of multimodal therapy. A combination of radiotherapy, chemotherapy and surgery is recommended for the optimal local and distant disease control. Moreover, better medical compliance and regular follow-up are required in these patients.

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Correlation between immunohistochemical expression of Ki-67and P63 and aggressiveness of urinary bladder urothelial carcinoma

Cited by 2 publications

References 15 publications

Prognostic Value of P63 Expression in Muscle-Invasive Bladder Cancer and Association with Molecular Subtypes—Preliminary Report

Prognostic Value of P63 Expression in Muscle-Invasive Bladder Cancer and Association with Molecular Subtypes—Preliminary Report

Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review

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