Correlation between images of silent brain infarction, carotid atherosclerosis and white matter hyperintensity, and plasma levels of acrolein, IL-6 and CRP

Yoshida, Madoka; Higashi, Kyohei; Kobayashi, Eiichi; Saeki, Naokatsu; Wakui, Kenji; Kusaka, Tadafumi; Takizawa, Hirotaka; Kashiwado, Koichi; Suzuki, Norikazu; Fukuda, Kazumasa; Nakamura, Toshio; Watanabe, Sakae; Tada, Kei; Machi, Yoshiki; Mizoi, Mutsumi; Toida, Toshihiko; Kanzaki, Tetsuto; Tomitori, Hideyuki; Kashiwagi, Keiko; Igarashi, Kazuei

doi:10.1016/j.atherosclerosis.2010.03.031

Cited by 56 publications

(43 citation statements)

References 28 publications

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“…PC-Acro, IL-6 and CRP were significantly higher in SBI and CA compared with the control. PC-Acro was most strongly associated with CA, and IL-6 and CRP with SBI [49]. Thus, CA is likely the primary risk factor related with stroke in this analysis.…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 89%

“…Accordingly, the median RRV of 175 mild subjects and 88 severe subjects was 0.67 and 0.90, respectively. With an increase in severity, from mild to severe, the association with SBI increased from 30 to 45% [49].…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 96%

“…Thus, RRV for the subjects with PVH or DSWMH and with both PVH and DSWMH was 0.34 and 0.55, respectively. With an increased severity of WMH, the association with SBI increased from 3.6 to 10% [49].…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 97%

“…6B). In this case, SBI, CA and WMH include subjects with single, double and triple pathologies [49].…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 99%

“…Since the levels of CRP and IL-6 are reported to increase in the serum of apparently healthy individuals with SBI [47], we measured the levels of CRP and IL-6 along with PC-Acro in plasma [48,49]. SBI (affected areas Z3 mm diameter) and WMH were estimated by MRI, CA by carotid ultrasound examination and CRP and IL-6 in plasma by ELISA.…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 99%

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Protein‐conjugated acrolein as a biochemical marker of brain infarction

Igarashi

Kashiwagi

2011

Molecular Nutrition Food Res

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The relationship between acrolein (CH(2) =CH-CHO) and brain infarction is the focus of this review. It has been found that acrolein is produced mainly within cells from polyamines by polyamine oxidases (PAOs), especially from spermine by spermine oxidase during cell damage, and that acrolein is more toxic than reactive oxygen species (ROS) in a cell culture system. Thus, the possibility that acrolein and PAOs are good biochemical markers of stroke was tested because there are no other reliable biochemical markers at the early stage of stroke. Levels of protein-conjugated acrolein (PC-Acro) and PAOs (acrolein-producing enzymes) were significantly increased in the plasma of stroke patients. The multiplied value of PC-Acro by PAOs was nearly parallel with the size of stroke. Furthermore, when the combined measurements of PC-Acro, interleukin-6 (IL-6) and C-reactive protein (CRP) were evaluated along with age using a receiver operating characteristic (ROC) curve, even silent brain infarction (SBI), which is a small brain infarction, was indicated with approximately 84% sensitivity and specificity. These findings clearly indicate that acrolein is strongly correlated with cell damage during brain infarction.

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Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 89%

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 96%

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 97%

“…6B). In this case, SBI, CA and WMH include subjects with single, double and triple pathologies [49].…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 99%

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 99%

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Protein‐conjugated acrolein as a biochemical marker of brain infarction

Igarashi

Kashiwagi

2011

Molecular Nutrition Food Res

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Acrolein and Unsaturated Aldehydes

Bein¹,

Leikauf²

2020

Environmental Toxicants

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l-Arginine and its metabolites in kidney and cardiovascular disease

et al. 2014

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L-Arginine is a semi essential amino acid synthesised from glutamine, glutamate and proline via the intestinal-renal axis in humans and most mammals. L-Arginine degradation occurs via multiple pathways initiated by arginase, nitric-oxide synthase, Arg: glycine amidinotransferase, and Arg decarboxylase. These pathways produce nitric oxide, polyamines, proline, glutamate, creatine and agmatine with each having enormous biological importance. Several disease are associated to an L-arginine impaired levels and/or to its metabolites: in particular various L-arginine metabolites may participate in pathogenesis of kidney and cardiovascular disease. L-Arginine and its metabolites may constitute both a marker of pathology progression both the rationale for manipulating L-arginine metabolism as a strategy to ameliorate these disease. A large number of studies have been performed in experimental models of kidney disease with sometimes conflicting results, which underlie the complexity of Arg metabolism and our incomplete knowledge of all the mechanisms involved. Moreover several lines of evidence demonstrate the role of L-arg metabolites in cardiovascular disease and that L-arg administration role in reversing endothelial dysfunction, which is the leading cause of cardiovascular diseases, such as hypertension and atherosclerosis. This review will discuss the implication of the mains L-arginine metabolites and L-arginine-derived guanidine compounds in kidney and cardiovascular disease considering the more recent literature in the field.

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Correlation between images of silent brain infarction, carotid atherosclerosis and white matter hyperintensity, and plasma levels of acrolein, IL-6 and CRP

Cited by 56 publications

References 28 publications

Protein‐conjugated acrolein as a biochemical marker of brain infarction

Protein‐conjugated acrolein as a biochemical marker of brain infarction

Acrolein and Unsaturated Aldehydes

l-Arginine and its metabolites in kidney and cardiovascular disease

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