Correlation Between IgA Tissue Transglutaminase Antibody Ratio and Histological Finding in Celiac Disease

Alessio, Maria Grazia; Tonutti, Elio; Brusca, Ignazio; Radice, Antonella; Licini, Lisa; Sonzogni, Aurelio; Florena, Ada Maria; Schiaffino, E; Marus, Wally; Sulfaro, Sandro; Villalta, Danilo

doi:10.1097/mpg.0b013e3182470249

Cited by 100 publications

(81 citation statements)

References 39 publications

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“…13 (59) 8 (36) 1 (5) 10 (45) 6 (27) 6 (27) 14 (64) 8 (36) 14 (78) 2 (11) 2 (11) 8 (44) 6 (33) 4 (22) 12 (67) 6 (33) 32 (54) 27 (46) -5 (8) 36 (61) 18 (31) 28 (48) 18 (82) 4 (18) 11 (50) 11 (50) -12 (55) 10 (45) 16 (89) 2 (11) 7 (39) 10 (56) 1 (6) 9 (50) 9 (50) 33 (56) 26 (44) 12 (20) 37 (63) 10 (17) 20 (34) The ESPGHAN guidelines [15] allow for the omission of a confirmatory SBB when clinical symptoms are present, together with a high anti-tTG titer of more than a tenfold increase and a typical HLA. These guidelines are based on pediatric studies and suggest that high anti-tTG antibody titers are almost 100% predictive of the presence of villous atrophy on SBB [16][17][18][19][20]. In clinical practice, pediatric patients are often referred with transient non-specific symptoms and are screened for CD as part of their evaluation by anti-tTG antibodies.…”

Section: Discussionmentioning

confidence: 99%

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

Loberman-Nachum¹,

Schvimer²,

Avivi³

et al. 2018

Dig Dis

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Background: The clinical, histological, and serological spectrum of celiac disease (CD) vary widely. We aimed to examine relationships between symptoms, serum anti-tissue transglutaminase antibodies (tTG) levels, mucosal damage, and mucosal anti-tTG deposits in pediatric CD. Methods: A retrospective single-center, cohort study of children referred for endoscopy with suspected CD during 2011–2014. We retrieved the clinical data, blindly reviewed duodenal biopsies, and performed immunohistochemical staining for anti-tTG deposits. Patients were classified as monosymptomatic or polysymptomatic. Mucosal anti-tTG deposits were classified according to the location of deposits, dominant intensity, maximal intensity, and percentage of stained area. Results: Of 252 patients with confirmed CD, complete data were available for 100: 37 males in the age range 1.3–16.7 with median 4.0 years. Monosymptomatic patients (n = 54) presented at an older age than polysymptomatic patients (1.3–15.5, median 8.1 vs. 1.3–16.7, median 6.3 years, p = 0.026). Marsh 2–3c was more prevalent in polysymptomatic patients (93 vs. 78%, p = 0.028). The intensity of mucosal anti-tTG deposits correlated with serum anti-tTG levels but not with the clinical presentation. Conclusions: Multiple symptoms and high serum anti-tTG antibody levels correlated with mucosal damage in children with CD. The role of immunohistochemical staining for intestinal anti-tTG mucosal deposits in the diagnosis of borderline CD is not yet established.

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Section: Discussionmentioning

confidence: 99%

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

Loberman-Nachum¹,

Schvimer²,

Avivi³

et al. 2018

Dig Dis

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“…The high values match the results from other studies that also find tTG IgA to be the most successful test together with EMA. 3,6,8,26,34,37 IgG tests. There is insufficient data about EMA IgG and tTG IgG in the selected studies to make firm conclusions.…”

Section: Discussionmentioning

confidence: 99%

Serological testing for celiac disease in adults

Schyum

Rumessen

2013

UEG Journal

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Background and aim: We present a systematic review on the performance of currently available methods for serological diagnosis of celiac disease (CD) and the role of human leukocyte antigen (HLA) typing. Objective: A literature survey was conducted using PubMed, MeSH database, Web of Science as well as manual searches. Results: Tissue transglutaminase antibodies (tTG) (IgA) (tested in nine studies) show sensitivities and specificities in the range of 0.76-0.968 and 0.909-0.98, and deamidated gliadin peptide (DGP) (IgA and IgG) (tested in eight studies) show sensitivities and specificities in the range of 0.69-0.984 and 0.903-1. Endomysial antibodies (EMA) (tested in five studies) show sensitivities and specificities in the range of 0.61-0.937 and 0.98-1, respectively. Combination assays (tested in three studies) using DGP þ tTG and DGP (IgA þ IgG) show sensitivities and specificities in the range of 0.87-1 and 0.8-1, respectively. HLA DQ2/DQ8 may be necessary for the development of CD-HLA DQ2 in particular. A possible close correlation may also exist between CD and HLA-G. Conclusion: DGP and tTG for serological testing for CD show equivalent diagnostic performance. More studies with, in particular, DGP alone and in combination with tTG are necessary before a firm recommendation can be made. HLA typing to exclude CD may still be controversial. It still seems premature to diagnose celiac disease in adults based on serology alone.

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“…Fewer studies checked two antibodies, mainly IgA-tTg and IgA-EMA, the latest being in 2012-13 [10][11][12][13]. Only in two Israeli studies, 5 different antibodies' levels were correlated to the mucosal damage [14,15].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Reliability of 17 Celiac Disease Associated Bio-Markers to Reflect Intestinal Damage

Lerner¹,

Jeremias²,

Neidhöfer³

et al. 2017

J Clin Cell Immunol

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Correlation Between IgA Tissue Transglutaminase Antibody Ratio and Histological Finding in Celiac Disease

Cited by 100 publications

References 39 publications

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

Serological testing for celiac disease in adults

Comparison of the Reliability of 17 Celiac Disease Associated Bio-Markers to Reflect Intestinal Damage

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