Correlation between Identification of β-Lactamase Resistance Genes and Antimicrobial Susceptibility Profiles in Gram-Negative Bacteria: a Laboratory Data Analysis

Mushtaq, Ammara; Chasan, Rachel; Nowak, Michael D.; Rana, Meenakshi; Ilyas, Sahrish; Paniz‐Mondolfi, Alberto; Sordillo, Emilia Mia; Patel, Gopi; Gitman, Melissa R.

doi:10.1128/spectrum.01485-21

Cited by 3 publications

(2 citation statements)

References 15 publications

(24 reference statements)

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“…Bacterial species were identified using the VITEK MS system [18] and AST was performed using the VITEK 2 system (bioMérieux, Inc., Durham, NC, USA) using cards AST-GN52 and AST-GN67 [19][20][21][22]; imipenem and ertapenem were included in both cartridges. Minimum inhibitory concentrations (MICs) were interpreted according to the breakpoints of the Clinical and Laboratory Standards Institute M100-ED29 : 2019 [23].…”

Section: Microbiologymentioning

confidence: 99%

Mortality difference from Klebsiella aerogenes vs Enterobacter cloacae bloodstream infections

Chou

Sucgang

Hamill

et al. 2023

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Members of the order Enterobacterales, including Escherichia coli , Klebsiella species and Enterobacter species, are important pathogens in healthcare-associated infections. Higher mortality has been reported from infections due to Klebsiella pneumoniae than from E. coli , but prior studies comparing Enterobacter aerogenes (recently renamed Klebsiella aerogenes ) bacteraemia and Enterobacter cloacae complex bacteraemia have yielded conflicting results regarding whether clinical outcomes differ. We found bacteraemia with K. aerogenes was independently associated with greater risk of 30-day mortality than bacteraemia with Enterobacter cloacae complex.

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Section: Microbiologymentioning

confidence: 99%

Mortality difference from Klebsiella aerogenes vs Enterobacter cloacae bloodstream infections

Chou

Sucgang

Hamill

et al. 2023

Access Microbiology

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“…CTX-M-type enzymes are the most commonly encountered ESBL types present in several members of the order Enterobacteriales (Yasmeen et al, 2023). Isolated isolates harboring CTX -M had great resistance to cefotaxime and low susceptibility to ceftazidime (Mushtaq, 2022). Other forms of ESBLs include OXAs, AmpCs, and carbapenemases.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of antibiotic resistance and virulence genes on plasmids of Proteus mirabilis isolated from urine samples of Hospitals in Mosul City, Iraq

Ibrahim,

Faisal

2024

JANS

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Antibiotic resistance genes when found on plasmids can be passed on to other strains causing spread of antibiotic resistance across bacteria. The present work aimed to identify virulence and resistance genes on Proteus mirabilis plasmids. A total of 37 P. mirabilis strains were isolated from 420 urine samples from patients attending different hospitals in Mosul City, Iraq, from December 2022 to April 2023 and identified using biochemical and molecular methods. Their resistance towards 18 antibiotics was tested and their plasmid DNA analysis showed that 21 of 37 Proteus strains contained plasmids. Four groups of primers were used for PCR experiments. The first group included primers used to identify six genetic regions, namely (CITM, DHAM, ACCM, EBCM, FOXM, MOXM1). Results showed that 85.71% of isolates carried FOXM on their plasmids and 14.28% carried MOXM and 4.76% carried CITM. However, DHAH, ACCM, and EBCM were not detected on plasmids. The second group included zapA, ireA (siderophore receptor), hpmA (hemolysin) and mrpA, (fimbriae) genes. zapA was detected in 80.95% of P. mirabilis plasmids, followed by ireA at a rate of 76.19%, hpmA at 14.28%, and mrpA at 4.76%. The third group included CTXG1, CTXG2, CTXG9, CTXG8 and CTXG25. The results showed that CTX9 was the highest gene detected, 76.19%, followed by CTXG1 71.42%, while CTXG2, CTXG8, and CTXG25 were only detected on the chromosome. Finally, the pathogenic genes PmIJ1 and qnrD were found on P. mirabilis plasmids at 52.38% and 47.61%, respectively. The present results showed that plasmids are increasingly spread among clinical local isolates of P. mirabilis, and serious precautions are required.

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BioFire FilmArray Blood Culture Identification (BCID) Panel and Clinical Usefulness: A Systematic Review

Gor,

Joshi

2024

Pediatric Infectious Disease

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Correlation between Identification of β-Lactamase Resistance Genes and Antimicrobial Susceptibility Profiles in Gram-Negative Bacteria: a Laboratory Data Analysis

Cited by 3 publications

References 15 publications

Mortality difference from Klebsiella aerogenes vs Enterobacter cloacae bloodstream infections

Mortality difference from Klebsiella aerogenes vs Enterobacter cloacae bloodstream infections

Molecular characterization of antibiotic resistance and virulence genes on plasmids of Proteus mirabilis isolated from urine samples of Hospitals in Mosul City, Iraq

BioFire FilmArray Blood Culture Identification (BCID) Panel and Clinical Usefulness: A Systematic Review

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