Correlation between<i>Saccharomyces cerevisiae</i>DNA in intestinal mucosal samples and anti-<i>Saccharomyces cerevisiae</i>antibodies in serum of patients with IBD

Mallant-Hent, RC; Mooij, Marlies J.; Blomberg, Bme von; Linskens, RK; Bodegraven, AA van; Savelkoul, Phm

doi:10.3748/wjg.v12.i2.292

Cited by 18 publications

(10 citation statements)

References 35 publications

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“…27 Other infectious agents have been linked to the diseases, 25 such as Listeria monocytogenes, 28 Chlamydia trachomatis, 29 Escherichia coli, 30 cytomegalovirus, 31 and Saccharomyces cerevisiae. 32 The spatial or spatiotemporal distribution of these agents is not understood and we can therefore not rule out any relationships between these microorganisms and the development of the diseases.…”

Section: Discussionmentioning

confidence: 99%

Geographic distribution and ecological studies of inflammatory bowel disease in southeastern Norway in 1990–1993

Jahnsen¹,

Bengtson²,

Moum³

et al. 2008

Inflammatory Bowel Diseases

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The geographic distribution of cases with IBD is not uniformly distributed and is related to urbanization, level of education, and moving pattern. Geographic distribution may be explained by either changes in environment-host relationships or neurobiological mechanisms due to stress and economic frustration. These factors and genetic predisposition might also explain increased familial clustering. Spatial clustering was significant neither for Crohn's disease CD nor ulcerative colitis (UC) but showed a stronger tendency within the CD group.

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Section: Discussionmentioning

confidence: 99%

Geographic distribution and ecological studies of inflammatory bowel disease in southeastern Norway in 1990–1993

Jahnsen¹,

Bengtson²,

Moum³

et al. 2008

Inflammatory Bowel Diseases

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show abstract

“…Mallant‐Hent et al41 investigated the correlation between ASCA and presence of mucosal S. cerevisiae DNA. ASCA was only rarely present in the mucosa, suggesting that the presence of serum antibodies is unlikely to be explained by continuous exposure to mucosal S. cerevisiae .…”

Section: Role Of Serological Antibodies In Ibd Pathogenesismentioning

confidence: 99%

Serological Antibodies in Inflammatory Bowel Disease: A Systematic Review

Prideaux

Cruz

et al. 2012

Inflammatory Bowel Diseases

171

145

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The diagnosis of inflammatory bowel disease (IBD) is traditionally based on a combination of clinical, endoscopic, histological, and radiological criteria. However, further testing is needed in cases of diagnostic uncertainty and in predicting disease course. This systematic review focuses on the potential for 10 serological antibodies to fill these roles: pANCA, ASCA, anti-OmpC, anti-CBir1, anti-I2, ALCA, ACCA, AMCA, anti-L, and anti-C. We discuss their prevalence in IBD and health; their role in disease diagnosis and risk stratification; their stability over time; their presence in unaffected relatives; their association with genetic variants; and differences across ethnic groups. Serological antibodies have some role in primary diagnosis and in differentiating between Crohn's disease and ulcerative colitis. In indeterminate colitis, preoperative measurement of serological antibodies can help to predict the likelihood of complications among patients undergoing pouch surgery. The combined presence and magnitude of a large panel of antibodies appear to be of value in predicting disease progression. There is currently insufficient evidence to recommend the use of antibody testing to predict responses to treatment or surgery in patients with IBD.

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“…Saccharomyces cerevisiae is the most common species of the genus Saccharomyces . ASCAs are thought to result from a specific antibody responding to the Saccharomyces cerevisiae cell wall mannan [35] . The major target of ASCAs is oligomannosidic epitopes of Saccharomyces cerevisiae , a strain of brewer's yeast.…”

Section: Antibodies Targeted Against Microbiota-derived Antigensmentioning

confidence: 99%

ASCA, ANCA, ALCA and Many More: Are They Useful in the Diagnosis of Inflammatory Bowel Disease?

Zhou

Song

Yang

et al. 2016

Dig Dis

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Background: Inflammatory bowel disease (IBD) is characterized by excessive immune responses to altered intestinal microbiota in genetically susceptible individuals. The diagnosis of IBD depends on clinical, endoscopic, histological, radiological and biochemical criteria, which may be invasive, time consuming and usually not accepted by patients with IBD. Key Messages: Serological biomarkers have been demonstrated to be a series of rapid, non-invasive approaches for assessments of early diagnosis, disease activity and prognosis for IBD. Importantly, serum antibodies against microbial antigens or auto-antigens have been used as biomarkers in predicting disease course, complications and responses to medications and surgery. Moreover, they have been demonstrated to be useful in distinguishing patients with Crohn's disease (CD) from those with ulcerative colitis (UC). Recently, a great number of new serum biomarkers (e.g., anti-glycoprotein 2, anti-granulocyte macrophage colony-stimulating factor, anti-neutrophil cytoplasmic antibody, anti-Saccharomyces cerevisiae antibody, anti-laminaribioside carbohydrate IgG antibody, anti-mannobioside carbohydrate IgG antibody, antibody to the outer membrane protein of Escherichia coli, anti-CBir1) have been found to be present in patients with IBD and are potentially used in the diagnosis and prediction. The presence of these antibodies in the sera is due to the disruption of intestinal mucosa barrier and they may reflect a possibly genetic loss of immunological tolerance toward microbiota-derived antigens. Due to their non-invasive, easily accessible, repetitive and economical characteristics, these biomarkers have been found to serve as precious supplementary means in the diagnosis and disease evaluation of IBD. Conclusions: Currently, the most important utility of serological biomarkers is to evaluate the aggressive risks of disease phenotype, complications or surgery requirement, predict prognosis of the disease and distinguish CD from UC. However, they have limited values in making initially definite diagnosis for IBD. Therefore, more effective biomarkers with high sensitivity and specificity need to be further explored in the future.

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Correlation betweenSaccharomyces cerevisiaeDNA in intestinal mucosal samples and anti-Saccharomyces cerevisiaeantibodies in serum of patients with IBD

Cited by 18 publications

References 35 publications

Geographic distribution and ecological studies of inflammatory bowel disease in southeastern Norway in 1990–1993

Geographic distribution and ecological studies of inflammatory bowel disease in southeastern Norway in 1990–1993

Serological Antibodies in Inflammatory Bowel Disease: A Systematic Review

ASCA, ANCA, ALCA and Many More: Are They Useful in the Diagnosis of Inflammatory Bowel Disease?

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