Correlation between Helicobacter pylori Infection and Metabolic Abnormality in General Population: A Cross-Sectional Study

Abstract

Background Previous studies have suggested a link between Helicobacter pylori (H. pylori) and metabolic abnormality. This study aimed at investigating the correlation between H. pylori infection and metabolic abnormality in a general population. Methods All enrolled participants underwent a carbon-13 urea breath test (13C-UBT). For each individual, the following data were collected: age, gender, alanine transaminase (ALT), total protein, albumin, cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), urea nitrogen, creatinine, uric acid, fasting plasma glucose, postprandial blood sugar, nonalcoholic fatty liver disease (NAFLD), and bone mineral density (BMD). Results The study included 1867 (393 females and 1474 males, aged 54.0 ± 9.6 years) people that took a physical examination. There was no significant difference in gender and age between the study participants with and without H. pylori infection. The statistical data are as follows: albumin: P = 0.045, uric acid: P = 0.025, fasting glucose: P = 0.043, and postprandial blood glucose: P = 0.035. In terms of the patients with NAFLD, there were significant differences in ALT and HDL-C between the study participants with and without H. pylori infection. TG (P = 0.048), HDL-C (P = 0.011), and fasting blood glucose (P = 0.018) were significantly different in both groups among individuals who got osteopenia. Conclusion H. pylori infection may be an important factor affecting metabolic abnormality and osteoporosis.

Association between Helicobacter pylori infection and nonalcoholic fatty liver disease: A systematic review and meta‐analysis of observational studies

“…Of these potential eligible articles, we excluded 13 articles (characteristics of excluded articles see Table ) by examining the abstracts or full‐texts carefully for more detailed assessment. Finally, fifteen studies met the inclusion criteria and were included in our meta‐analysis. The detailed flowchart of selection process of eligible studies is shown in Figure .…”

“…As to H. pylori testing method, seven studies used UBT, four used serology to detect antibodies to H. pylori , one used RUT, one used SAT, and two used multiple methods . Regarding confounders adjustment, only five studies did not adjust for confounders . The confounders were obviously different across remaining ten studies.…”

“…These studies were published between 2013 and 2018, three of which were conference abstracts. 23,26,30 Our meta-analysis contained eleven cross-sectional studies, [23][24][25][26]28,30,[32][33][34][35][36] two case-control studies, 22,27 one retrospective cohort study, 29 and one prospective multicenter cohort. 31 Eleven of these studies were from Asia, [23][24][25][27][28][29][30]32 two studies from the United States, 26,34 one from Greece, 22 and one from Egypt.…”

Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy

“…Briefly, most studies reported higher rates of H pylori ‐I in NAFLD patients and, inversely, higher rates of NAFLD in H pylori ‐infected individuals (Table ). However, a minority of studies reported no association between H pylori ‐I and NAFLD . Only one study reported inverse association, that is, lower rates of NASH in H pylori ‐infected than noninfected individuals; in the same study, H pylori ‐infected individuals had higher rates of steatosis than noninfected ones, which is a seeming paradox .…”

“…Following the aforementioned initial reports, there have been amounting data from observational studies (mostly cross‐sectional) having evaluated the potential association between H pylori ‐I and NAFLD . The main characteristics and results of these studies are summarized in Table .…”