Correlation between hyperuricemia and lipid profile in untreated dyslipidemic patients

Abstract

There are a number of epidemiological studies that suggest the association of cardiovascular diseases and uric acid but very few studies highlight the direct association of deranged lipid profile with uric acid levels. The present study was indented to find out if any association exists between hyperuricemia and dyslipidemia. Blood samples were collected from healthy controls (n=70) and patients with dyslipidemia (n=70) who were not receiving any treatment for dyslipidemia. These samples were processed for estimating lipid profile and uric acid levels. The parameters in the two groups were compared. Correlation between different parameters was calculated by Pearson correlation analysis in both the groups. Uric acid levels (6.40 ± 1.27 vs 4.89 ± 0.21 mg/dl, P<0.001) were significantly higher in patients as compared to those in controls. There was significant increase in the levels of total cholesterol (TC), triglycerides (TAGs), LDL-C, VLDL-C, non-HDL cholesterol (P<0.001 in each case), in patients of dyslipidemia. However, significant decrease in the levels of HDL-C (P<0.001) was seen in patients compared to controls. LDL-C/HDL-C ratio (P<0.001), TC/HDL-C ratio (P<0.001) and TAG/HDL-C ratio (P<0.001) were also significantly increased in dyslipidemic subjects when compared to controls. Uric acid had significant correlations with TC (r=0.334, P<0.001), TAGs (r = 0.288, P<0.001), LDL-C (r = 0.241, P<0.001), VLDL-C (r= 0.158, P<0.001) and HDL-C (r=-0.652, P<0.001) in patients. Results of this study imply that there is higher association of hyperuricemia in dyslipidemic patients than normal subjects. Therefore treatment of underlying hyperuricemia should be an important aspect in planning the treatment strategy for dyslipidemia to reduce the cardiovascular morbidity.

Association of Serum Uric Acid With Metabolic Syndrome Components in Syrian Population

“…Regarding lipid profile, our results showed that SUA had a positive correlation with TC, TG and LDL-C, and a negative correlation with HDL-C, implying its association with dyslipidemia which was also described by other studies 43,44 . These effects are mainly attributed to the role uric acid plays in regulating fructokinase expression in hepatocytes, leading to an enhanced lipogenic impact of fructose.…”

Cholesterol Level as Predicting of Uric Acid Increase in Elderly

“…Prevalence uric acid in Indonesia 18%. 5 Previous study in Korea that average rate of hypercholesterolemia 36%. 7 Study in China 8 that range of risk factors mortality of elderly including obesity, hyperglycemia, high blood pressure, high triglycerides, and cholesterol.…”

“…The incidence of uric acid up to 46% and is predicted in 2030 th to 8 million people. 4 Prevalence uric acid in Asia regions total of 24 countries, that the lowest Papua New Guinea 1% and highest Marshall Islands 85% 5 . Study in Sydney 6 Australia that prevalence of hyperuricemia was 22.2%.…”