Correlation between hyperglycemia and retinopathy of prematurity

Ahmadpour-Kacho, Mousa; Motlagh, Alireza Jashni; Rasoulinejad, Seyed Ahmad; Jahangir, Tahereh; Bijani, Ali; Pasha, Yadollah Zahed

doi:10.1111/ped.12371

Cited by 33 publications

(29 citation statements)

References 27 publications

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“…Hyperglycemia was significant after adjustment for the other risk factors (2,(12)(13)(14)(15) . In the literature, hyperglycemia is regarded as a marker of acute critical state, reflecting its severity and insulin resistance (1,16,17) .…”

Section: Discussionmentioning

confidence: 93%

Influence of the blood glucose level on the development of retinopathy of prematurity in extremely premature children

Nicolaeva¹,

Sidorenko²,

Iosifovna³

2015

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Research Ethics Committee of Pirogov Russian National research medical university, meeting date: 12.12.2011. Project number: 113. ABSTRACTPurpose: To investigate the influence of the blood glucose level on the development of retinopathy of prematurity (ROP) in extremely premature infants. Methods: Sixty-four premature infants with a gestational age of less than 30 weeks and a birth weight of less than 1500 g were included in the study. Children without ROP were allocated to Group 1 (n=14, gestational age 28.6 ± 1.4 weeks, birth weight 1162 ± 322 g), and children with spontaneous regression of ROP were allocated to Group 2 (n=32, gestational age 26.5 ± 1.2 weeks, birth weight 905 ± 224 g). Children with progressive ROP who underwent laser treatment were included in Group 3 (n=18, gestational age 25.4 ± 0.7 weeks, birth weight 763 ± 138 g). The glucose level in the capillary blood of the premature infants was monitored daily during the first 3 weeks of life. A complete ophthalmological screening was performed from the age of 1 month. The nonparametric signed-rank Wilcoxon-Mann-Whitney test was used for statistical analysis. Results:The mean blood glucose level was 7.43 ± 2.6 mmol/L in Group 1, 7.8 ± 2.7 mmol/L in Group 2, and 6.7 ± 2.6 mmol/L in Group 3. There were no significant differences in the blood glucose levels between children with and without ROP, and also between children with spontaneously regressing ROP and progressive ROP (p>0.05). Additionally, there were no significant differences in the blood glucose levels measured at the first, second, and third weeks of life (p>0.05). Conclusion:The blood glucose level is not related to the development of ROP nor with its progression or regression. The glycemic level cannot be considered as a risk factor for ROP, but reflects the severity of newborns' somatic condition and morphofunctional immaturity.

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Section: Discussionmentioning

confidence: 93%

Influence of the blood glucose level on the development of retinopathy of prematurity in extremely premature children

Nicolaeva¹,

Sidorenko²,

Iosifovna³

2015

Arquivos Brasileiros De Oftalmologia

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“…Four out of 9 studies provided the mean glucose level of hyperglycemia9212225. Pooling up the data from these 4 studies showed that the mean glucose level was significantly higher in the ROP compared to the non-ROP group (SMD = 0.88, 95% CI: 0.40–1.37, I 2 = 78%, P = 0.0004, Figure 3B).…”

Section: Resultsmentioning

confidence: 99%

“…Seven out of the 9 studies provided primary data on the number of subjects with hyperglycemia and without hyperglycemia in both the ROP and non-ROP groups21222324252627. Pooling up data from these 7 studies showed that hyperglycemia is associated with ROP with an unadjusted OR of 4.16 (95% CI: 2.09–8.29, I 2 = 65%, P <0.0001) (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…In particular, 3 studies provided the adjusted ORs of the association between duration of hyperglycemia and ROP212528. Combining all these adjusted ORs, duration of hyperglycemia showed a borderline association with ROP (adjusted OR = 1.08, 95% CI: 1.01–1.15, I 2 = 49%, P = 0.03, Figure 4A).…”

Section: Resultsmentioning

confidence: 99%

“…In particular, 3 studies provided adjusted ORs of the association between the mean glucose level in hyperglycemia and ROP92122. Combining these adjusted ORs revealed that the mean glucose level in hyperglycemia was not associated with ROP (adjusted OR = 1.08, 95% CI: 0.97–1.20, I 2 = 68%, P = 0.15, Figure 4B).…”

Section: Resultsmentioning

confidence: 99%

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Association between hyperglycemia and retinopathy of prematurity: a systemic review and meta-analysis

Tang

Rong

et al. 2015

Sci Rep

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As the role of hyperglycemia in the development of retinopathy of prematurity (ROP) has not been well established, a meta-analysis of the association between hyperglycemia and ROP was conducted. Studies were identified through literature search in MEDLINE and EMBASE up to June 20, 2014 with keywords related to “hyperglycaemia” and “ROP”. Nine eligible studies involving 1939 neonates with 509 cases of ROP were included. Unadjusted analyses showed that hyperglycemia was significantly associated with ROP (Odds ratio [OR] = 4.16, P<0.0001). Comparing with the control, subjects in the ROP group had a significantly longer duration of hyperglycemia (Standardized mean difference [SMD] = 1.21, P< 0.0001), and higher mean glucose level. (SMD = 0.88, P = 0.0004) However, when combining the adjusted OR (after adjustment for birth weight, gestational age and other factors) provided from individual studies, only borderline significant association were observed on duration of hyperglycemia with ROP (adjusted OR 1.08, P = 0.03); and no significant association on mean glucose level with ROP (adjusted OR = 1.08, P = 0.15). Hence, hyperglycemia cannot be definitely considered as a risk factor for ROP, and further studies should adjust for potential confounding factors to clarify this association.

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Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study

Fevereiro-Martins¹,

Santos²,

Marques-Neves³

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Purpose To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed. Results A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression. Conclusion In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.

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Correlation between hyperglycemia and retinopathy of prematurity

Abstract: Hyperglycemia is an important risk factor for ROP that can be prevented along with other risk factors by accurate supervision.

Cited by 33 publications

References 27 publications

Influence of the blood glucose level on the development of retinopathy of prematurity in extremely premature children

Influence of the blood glucose level on the development of retinopathy of prematurity in extremely premature children

Association between hyperglycemia and retinopathy of prematurity: a systemic review and meta-analysis

Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study

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