Correlation between HPV-negative cervical lesions and cervical microenvironment

Zheng, Jingjing; Miao, Jing-Rui; Wu, Qiang; Yu, Cong-Xiang; Mu, Liangshan; Song, Jinghui

doi:10.1016/j.tjog.2020.08.002

Cited by 18 publications

(28 citation statements)

References 15 publications

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“…8,10 Patients with HR-HPV-associated cervical lesions showed a decrease in normally dominant Lactobacillus populations and an increase in Gardnerella, unlike healthy women. 11,12 Furthermore, Gardnerella vaginalis and Prevotella were found to be associated with cervical intraepithelial neoplasia (CIN) persistence and slower regression. 13 However, the interactions between BV and persistent HR-HPV infection in women of childbearing age remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Some genital tract BV‐related bacteria may also be associated with neoplasms, including Atopobium vaginae , Prevotella , Gardnerella , Sneathia sanguinegens and Fusobacterium 8,10 . Patients with HR‐HPV‐associated cervical lesions showed a decrease in normally dominant Lactobacillus populations and an increase in Gardnerella , unlike healthy women 11,12 . Furthermore, Gardnerella vaginalis and Prevotella were found to be associated with cervical intraepithelial neoplasia (CIN) persistence and slower regression 13 .…”

Section: Introductionmentioning

confidence: 99%

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Prevotella as the hub of the cervicovaginal microbiota affects the occurrence of persistent human papillomavirus infection and cervical lesions in women of childbearing age via host NF‐κB/C‐myc

Dong

Huang

Cai

et al. 2022

Journal of Medical Virology

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There is evidence that coinfection of cervicovaginal high-risk human papillomavirus (HR-HPV) and bacteria is common in women of childbearing age. However, the relationship between bacterial vaginosis (BV) and persistent HR-HPV infection in women of childbearing age and the underlying mechanisms remain unclear. In this study, we determined whether BV affects persistent HR-HPV infection in women aged 20-45 years and explored the possible mechanisms of their interactions. From January 1 to April 30, 2020, we recruited women aged 20-45 years with and without BV at a ratio of 1:2 from Fujian Maternity and Child Health Hospital. All women were followed up at 0, 12, and 24 months. A BV assay, HR-HPV genotyping and cervical cytology were performed at each follow-up. At 0 months, additional vaginal secretions and cervical exfoliated cells were collected for 16S ribosomal RNA sequencing, bacterial metabolite determination, and POU5F1B, C-myc, TLR4, NF-κB, and hTERT quantification. A total of 920 women were included. The

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevotella as the hub of the cervicovaginal microbiota affects the occurrence of persistent human papillomavirus infection and cervical lesions in women of childbearing age via host NF‐κB/C‐myc

Dong

Huang

Cai

et al. 2022

Journal of Medical Virology

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“…In this study, the overexpression of CYP2E1 could be caused by metabolites generated by co-infection with other microbes, as has been described in previous studies [ 5 , 6 , 25 ], and the higher overexpression in MI over SI could be explained by the higher abundance of HPV diversity and a higher abundance of resident microbes. In studies of microbial metabolites and HR-HPV in women, it has been demonstrated that H 2 O 2 and HR-HPV were significatively correlated [ 37 ] along with higher biogenic amines and lower glutathione and lipid concentrations [ 38 ]. In addition, it has recently been shown that in human sperm, alterations in water and hydrogen peroxide diffusion are related to a direct interaction of viral L1 protein of HPV with aquaporin-8 [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

High-Risk HPV with Multiple Infections Promotes CYP2E1, Lipoperoxidation and Pro-Inflammatory Cytokines in Semen of Asymptomatic Infertile Men

et al. 2022

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High-risk human papillomavirus (HR-HPV) infection, followed by chronic inflammation and oxidative stress, is a major risk factor of male infertility. In this study, we explored the potential impact of high-risk (HR) HPV genotypes in single infection (SI) and multiple infections (MI) that promote CYP2E1 expression, oxidative damage and pro-inflammatory cytokines, possibly contributing to sperm damage and male infertility. Semen samples from 101 infertile military men were studied. We analyzed seminal parameters, namely, HPV genotyping, cytochrome P450 2E1 (CYP2E1), oxidative stress biomarkers (total antioxidant capacity (TAC), catalase (CAT) and superoxide dismutase (SOD)), lipid peroxidation (LPO), 8-hydroxiguanosine (8-OHdG) and pro-inflammatory cytokines (IFN-γ, IL-1β, IL-4, IL-6 and IL-8). Eighty-one men (80.2%, 81/101) were positive for HPV infection, and MI-HR-HPV was higher than SI-HR-HPV (63% vs. 37%). HPV-52 was the most frequently detected type (18.5%), followed by HPV-33 (11.1%), and the most frequent combination of genotypes detected was HPV-33,52 (11.1%), followed by HPV-18,31 (6.2%). The group with infected samples presented lower normal morphology and antioxidant levels compared to non-infected samples. In concordance, the infected group showed high levels of LPO, IFN-γ, IL-1β, IL-4 and IL-6 and downregulation of CAT and SOD enzymes. Interestingly, changes in motility B, low levels of TAC, overexpression of CYP2E1, LPO and IL-8 levels were higher in MI-HR-HPV than SI-HR-HPV, suggesting that HPV infection promotes a chronic inflammatory process and a toxic and oxidative microenvironment, which increases with MI-HPV infections.

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“…We found four articles for the quantitative synthesis regarding the HPV-positive population when evaluating the association between T. vaginalis infection and cervical lesions. 17,50,51,57 For LSIL, three articles were analyzed, assessing 1932 women in the exposure group and 20 033 in the control group. 17,50,51 Trichomonas vaginalis-positive women had 2.81 higher odds for LSIL diagnosis than women who were not T. vaginalis infected (95% CI 2.37-3.33; I 2 0%; see Figure 5).…”

Section: Association Between T Vaginalis Cervical Lesions and Cervica...mentioning

confidence: 99%

Trichomonas vaginalis infection is associated with increased risk of cervical carcinogenesis: A systematic review and meta‐analysis of 470 000 patients

Hamar

Teutsch

Hoffmann

et al. 2023

Intl J Gynecology & Obste

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BackgroundTrichomonas vaginalis infection is the most prevalent non‐viral sexually transmitted infection (STI) in women and has been suggested as a risk factor for developing cervical cancer.ObjectiveWe aimed to investigate the associations between T. vaginalis infection and cervical carcinogenesis.Search StrategyA comprehensive systematic search was conducted in five databases on 21 October 2021.Selection CriteriaStudies assessing the relationship between T. vaginalis infection, HPV co‐infections, cervical dysplasia, and cervical cancer were found eligible.Data Collection and AnalysisSummary estimates for pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated with a random‐effects model. Statistical heterogeneity was measured with I2 and Cochran's Q tests.Main ResultsThe 29 articles included 473 740 women, of whom 8518 were T. vaginalis‐positive. Our results showed that T. vaginalis‐infected women had 1.79 times higher odds of being diagnosed with HPV co‐infection (95% CI 1.27–2.53; I2 95%). We also found that T. vaginalis infection was associated with high‐grade squamous intraepithelial lesion diagnosis (OR 2.34, 95% CI 1.10–4.95; I2 75%) and cervical cancer (OR 5.23, 95% CI 3.03–9.04; I2 3%).ConclusionsOur results showed an association between T. vaginalis and cervical carcinogenesis in sexually active women.

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Correlation between HPV-negative cervical lesions and cervical microenvironment

Cited by 18 publications

References 15 publications

Prevotella as the hub of the cervicovaginal microbiota affects the occurrence of persistent human papillomavirus infection and cervical lesions in women of childbearing age via host NF‐κB/C‐myc

Prevotella as the hub of the cervicovaginal microbiota affects the occurrence of persistent human papillomavirus infection and cervical lesions in women of childbearing age via host NF‐κB/C‐myc

High-Risk HPV with Multiple Infections Promotes CYP2E1, Lipoperoxidation and Pro-Inflammatory Cytokines in Semen of Asymptomatic Infertile Men

Trichomonas vaginalis infection is associated with increased risk of cervical carcinogenesis: A systematic review and meta‐analysis of 470 000 patients

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