Correlation between histopathologic findings of psoriasis determined using quantitative computer-aided analysis and elements of the Psoriasis Area and Severity Index

Kim, Sung Ae; Choi, Jae Woo; Kim, Bo Ri; Youn, Sang Woong

doi:10.1016/j.jaad.2015.04.057

Cited by 9 publications

(8 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The following histopathological characteristics were examined: epidermal thickness, horny layer thickness, rete ridge count, grade of inflammatory cellular infiltration, and grade of papillary dermal vessel dilatation. Kim et al [ 11 ]. reported that the severity of dilatation was correlated with the clinical severity of psoriasis.…”

Section: Methodsmentioning

confidence: 99%

Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression

Jung

Yang

Bang

et al. 2021

JCM

View full text Add to dashboard Cite

Several studies have determined the correlation between programmed cell death protein-1 (PD-1) and chronic plaque psoriasis (CPP). However, limited studies have assessed the association between PD-1 expression and the clinicoprognostic and distinct clinicopathological characteristics of CPP and guttate psoriasis (GP). Twenty-nine patients with skin biopsy-confirmed CPP were recruited at the Asan Medical Center between January 2018 and June 2020, and 33 patients with biopsy-confirmed GP were enrolled between January 2002 and June 2020. The clinicoprognostic and histopathological characteristics were analyzed according to immunohistochemical PD-1 expression in the epidermal or dermal inflammatory infiltrates. The CPP and GP lesions were divided into PD-1-low and PD-1-high groups. The CPP epidermal PD-1-high group had typical histopathological changes and significantly higher psoriasis area and severity index scores (p = 0.014) and disease duration (p = 0.009) than the epidermal PD-1-low group. In patients with GP, compared with the dermal PD-1-high group, the dermal PD-1-low group exhibited significantly higher disease duration (p = 0.002) and relapse rate of plaque psoriasis (p = 0.005) and significantly lower relapse-free survival (p = 0.016). Upregulated epidermal PD-1 expression was correlated with the chronicity and severity of CPP, while downregulated dermal PD-1 expression was correlated with poor prognosis of GP.

show abstract

Section: Methodsmentioning

confidence: 99%

Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression

Jung

Yang

Bang

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…Recently, quantitative computer‐aided image analysis (qCAIA) has been performed in a wide range of medical sciences and has enabled researchers to assess histopathological findings and to measure the severity of disease objectively by using quantified parameters 7–9 …”

Section: Introductionmentioning

confidence: 99%

Histopathological predictor of the progression from actinic keratosis to squamous cell carcinoma: quantitative computer‐aided image analysis

Lee

Kim

Yang

et al. 2020

Acad Dermatol Venereol

View full text Add to dashboard Cite

BackgroundThe current histopathological classifications for actinic keratosis (AK) are subjective, and histopathological factors predicting the progression into invasive squamous cell carcinoma (SCC) remain unclear.ObjectivesTo quantitatively assess the histopathological findings of AK and to investigate the predisposing factors for malignant transformation of AK.MethodsA total of 502 AK specimens were retrospectively reviewed. The AK lesions were divided into the atrophic, intermediate, hypertrophic and bowenoid types. Histopathological features were quantitatively analysed using computer‐aided image analysis.ResultsThe epidermal thickness excluding the horny layer increased with statistical significance (P < 0.001) in order of atrophic, intermediate, hypertrophic and bowenoid type. The proportion of keratinocytic atypia was not significantly different among subtypes, except for the bowenoid type. Five of 498 cases were confirmed to develop into SCC. Bowenoid type, epidermal thickening and higher proportion of keratinocytic atypia were significantly associated with progression to invasive SCC in univariate analysis (OR = 12.571, 95% CI: 1.392–113.57; OR = 1.004, 95% CI: 1.001–1.007; OR = 1.069, 95% CI: 1.011–1.130, respectively). In multivariate analysis, only the proportion of keratinocytic atypia was an independent predisposing factor for progression to invasive SCC (OR = 1.069; 95% CI: 1.011–1.130).ConclusionsHistopathological subtypes based on the essential change of the epidermis well correlated with the actual epidermal thickness excluding the horny layer. The overall severity of keratinocytic atypia might be an independent risk factor for malignant transformation of AK.

show abstract

“…Objective verification of these subtle differences would help dermatologists diagnose these diseases clinically. In previous studies, the clinical and pathologic images of various skin diseases were quantitatively analyzed using computer-aided image analysis (CAIA) [11][12][13][14] . The CAIA parameters derived from these studies made it possible to objectively differentiate clinically similar diseases or different histological subtypes within a disease.…”

Section: Introductionmentioning

confidence: 99%

Predictive Model for Differential Diagnosis of Inflammatory Papular Dermatoses of the Face

Kim

Choi

et al. 2020

Ann Dermatol

Self Cite

View full text Add to dashboard Cite

Background The clinical features of inflammatory papular dermatoses of the face are very similar. Their clinical manifestations have been described on the basis of a small number of case reports and are not specific. Objective This study aimed to use computer-aided image analysis (CAIA) to compare the clinical features and parameters of inflammatory papular dermatoses of the face and to develop a formalized diagnostic algorithm based on the significant findings. Methods The study included clinicopathologically confirmed inflammatory papular dermatoses of the face: 8 cases of eosinophilic pustular folliculitis (EPF), 13 of granulomatous periorificial dermatitis-lupus miliaris disseminatus faciei (GPD-LMDF) complex, 41 of granulomatous rosacea-papulopustular rosacea complex (GR-PPR) complex, and 4 of folliculitis. Clinical features were evaluated, and area density of papular lesions was quantitatively measured with CAIA. Based on these variables, we developed a predictive model for differential diagnosis using classification and regression tree analysis. Results The EPF group showed lesion asymmetry and annular clusters of papules in all cases. The GPD-LMDF complex group had significantly higher periocular density. The GR-PPR complex group showed a higher area density of unilateral cheek papules and the highest total area density. According to the predictive model, 3 variables were used for differential diagnosis of the 4 disease groups, and each group was diagnosed with a predicted probability of 67%~100%. Conclusion We statistically confirmed the distinct clinical features of inflammatory papular dermatoses of the face and proposed a diagnostic algorithm for clinical diagnosis.

show abstract

Correlation between histopathologic findings of psoriasis determined using quantitative computer-aided analysis and elements of the Psoriasis Area and Severity Index

Cited by 9 publications

References 4 publications

Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression

Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression

Histopathological predictor of the progression from actinic keratosis to squamous cell carcinoma: quantitative computer‐aided image analysis

Predictive Model for Differential Diagnosis of Inflammatory Papular Dermatoses of the Face

Contact Info

Product

Resources

About