Correlation Between Histopathologic Features and Magnetic Resonance Images of Spinal Cord Lesions

Ohshio, Itaru; Hatayama, Akihiro; Kaneda, Kiyoshi; Takahara, Masatoshi; Nagashima, Kazuo

doi:10.1097/00007632-199307000-00005

Cited by 166 publications

(109 citation statements)

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“…On the other hand, the low-intensity area on T1-weighted MRI in the subacute and chronic stages is thought to indicate necrosis or myelomalacia. 5,9 We thought that the T1-weighted low-intensity area on MRI at the subacute stage reflected the damage area of spinal cord. It was difficult to measure accurately the changed area of the spinal cord by edema in T2-weighted image.…”

Section: Discussionmentioning

confidence: 99%

“…MRI can show the degree of spinal canal stenosis, as well as reveal the intramedullary state of the spinal cord in detail. 5 To our knowledge, there have been only few reports on the MRI features of patients with CSCI without major bone injury. 6,7 The most common acute MRI pattern described is no change of signal intensity on T1-weighted images with a blurred high-intensity area on T2-weighted images.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the low-intensity area on T1-weighted images obtained in the subacute and chronic stages is thought to indicate necrosis, myelomalacia or an intramedullary cyst. 5,9 Some papers have described the early relationship between MRI features and clinical outcomes in patients with CSCI at the acute stage following trauma. 8,10,11 However, to the best of our knowledge, there are few papers reporting about this relationship at subacute or chronic stages following trauma.…”

Section: Introductionmentioning

confidence: 99%

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Subacute T1-low intensity area reflects neurological prognosis for patients with cervical spinal cord injury without major bone injury

et al. 2015

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Study design: A retrospective imaging and clinical study. Objectives: To evaluate the relationship between magnetic resonance imaging (MRI) features and neurological prognosis in patients with traumatic cervical spinal cord injury (CSCI) without major bone injury. Methods: A total of 72 patients with CSCI without major bone injury were treated conservatively in our hospital. MRI was performed for all patients at admission and 1 month following injury. We measured the antero-posterior and cranio-caudal diameter of intramedullary intensity changed area with T1-weighted images at the injured segment. Neurological evaluations were performed using the American Spinal Injury Association (ASIA) motor score and the modified Frankel grade at the time of admission and discharge.Results: There was a significant relationship between the antero-posterior diameter ratio of the T1-weighted low-intensity area on MRI at the subacute stage and the ASIA motor score. The optimal threshold of the T1-weighted low-intensity diameter ratio for predicting the patient's ability to walk with or without assistance at discharge was determined to be 46%. Moreover, 96.8% of the patients with o50% T1-weighted low-intensity area recovered to walk with or without a cane at discharge. Conclusion: The T1-low intensity area may be an important predictive factor for the neurological recovery of CSCI without major bone injury.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Subacute T1-low intensity area reflects neurological prognosis for patients with cervical spinal cord injury without major bone injury

et al. 2015

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“…6,7 SI changes of the spinal cord on MRI in CSM patients are thought to reflect pathological changes in the spinal cord and to be indicative of the prognosis. 11,12 With development in MRI techniques Abbreviations: GSI, grayscale of signal intensity; JOA, Japanese Orthopedic Association; MRI, magnetic resonance imaging; RGSI, ratio of grayscale of signal intensity; TA, transverse area.…”

Section: Discusionmentioning

confidence: 99%

“…[2][3][4][5] There is no doubt that magnetic resonance imaging (MRI) is the best radiological modality for examination and evaluation of patients with CSM. MRI can show not only the etiology of myelopathy but also the intramedullary state of the spinal cord in detail, 6,7 thereby helping in both the diagnosis and prognosis of CSM. 8,9 To date, postoperative MRI has not yet been fully studied in relation to the correlation of morphology or signal change of cervical cord and longer-term prognosis in CSM patients.…”

Section: Introductionmentioning

confidence: 99%

Quantitative magnetic resonance imaging analysis correlates with surgical outcome of cervical spondylotic myelopathy

Wang

et al. 2014

Spinal Cord

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Study design: Prospective study. Objectives: To investigate whether preoperative and postoperative changes of signal intensity (SI) and transverse area (TA) of the spinal cord reflect the surgical outcome in patients with cervical spondylotic myelopathy (CSM). Setting: The Second Hospital of Tangshan, Tangshan, Hebei, China. Methods: In 45 consecutive prospective patients, magnetic resonance imaging (MRI) was performed preoperatively and 3 months postoperatively. The Japanese Orthopedic Association (JOA) scale was used to quantify the neurological status at admission and of at least 12-month follow-up. Preoperative and postoperative TA of the spinal cord at the site of maximal compression and grayscale of signal intensity (GSI) were measured using the image analysis software. Ratio of transverse area (RTA) and ratio of grayscale of signal intensity (RGSI) were used to assess the extent of spinal cord re-expansion and extent of SI regression. Preoperative status and postoperative recovery were assessed in relation to MRI parameters preoperatively and postoperatively using univariate and multivariate analysis. Results: Higher baseline JOA scores were associated with larger TA. Greater recovery rate was associated with larger preoperative and postoperative TA, along with greater RTA. Recovery rate negatively correlated with RGSI and age. Higher baseline JOA score was associated with greater recovery rate. RGSI negatively correlated with RTA. Multivariate stepwise regression analysis showed that the optimal combination of surgical outcome predictors included age, postoperative TA and RGSI. 1 The natural history of CSM is progressive neurological deterioration in the majority of patients. The surgical intervention have been advocated to alter the natural history and improve the prognosis of patients with CSM. How to predict neurological outcomes after surgery is of great importance for the management of CSM patients. Various factors that may influence the surgical outcome include the patient's age, duration of myelopathic symptoms, baseline neurological status, preoperative signal changes on magnetic resonance images and TA of the spinal cord. [2][3][4][5] There is no doubt that magnetic resonance imaging (MRI) is the best radiological modality for examination and evaluation of patients with CSM. MRI can show not only the etiology of myelopathy but also the intramedullary state of the spinal cord in detail, 6,7 thereby helping in both the diagnosis and prognosis of CSM. 8,9 To date, postoperative MRI has not yet been fully studied in relation to the correlation of morphology or signal change of cervical cord and longer-term prognosis in CSM patients. In our study, we have focused on quantitative analysis of signal intensity (SI) and transverse area (TA) of the spinal cord on T2-weighted MRI preoperatively and postoperatively. The purpose of the present study was to investigate

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Advanced Imaging

Nykamp¹

2017

Current Techniques in Canine and Feline Neurosurgery

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Correlation Between Histopathologic Features and Magnetic Resonance Images of Spinal Cord Lesions

Cited by 166 publications

References 0 publications

Subacute T1-low intensity area reflects neurological prognosis for patients with cervical spinal cord injury without major bone injury

Subacute T1-low intensity area reflects neurological prognosis for patients with cervical spinal cord injury without major bone injury

Quantitative magnetic resonance imaging analysis correlates with surgical outcome of cervical spondylotic myelopathy

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