Correlation between histological effects on the main tumors and nodal status after chemoradiotherapy for squamous cell carcinoma of the esophagus

Abstract

The effects of chemoradiotherapy against main tumors significantly correlated with nodal status. Most patients with main tumors of pathological CR are node-negative. Patients with a grade 2 response have at most a few positive nodes. Surgery would be most beneficial for such patients.

Pathological analysis after neoadjuvant chemoradiotherapy for esophageal carcinoma: The rotterdam experience

“…Patients with complete tumor regression had significantly less pathological nodal involvement. This correlation between the histomorphological response to chemoradiotherapy and pathological nodal involvement is seen by other authors [24,25].…”

Salvage esophagectomy after definitive chemoradiotherapy for thoracic esophageal cancer

“…In the CRT treatment regimen, a single daily fraction of 2 Gy was administered concurrently with cisplatin and 5-FU. The latter was administered by continuous intravenous infusion at a dose of 400 mg/m 2 , in combination with cisplatin at 10 mg/m 2 by drip infusion for 5 days/week [35]. Radiation was applied via a 10 MV X-ray linear accelerator.…”

Correlation between tumor blood flow assessed by perfusion CT and effect of neoadjuvant therapy in advanced esophageal cancers

“…The treatment regimen of neoadjuvant ChT was as follows: cisplatin at a dose of 70 mg/m 2 and doxorubicin hydrochroride (Adriamycin) at a dose of 35 mg/m 2 was given by drip infusion on day 1; 5-fluorouracil (5-FU) was administered at a dose of 700 mg/m 2 by continuous infusion on days 1 through 7 [26,27]. CRT was performed as follows: a total of 40 Gy external-beam irradiation was delivered daily 2 Gy by a 10-MV linear accelerator with parallel opposing fields using anterior and posterior portal arrangements, with concurrent ChT including daily administration of CDDP 7 mg/m 2 and 5Fu 350 mg/m 2 [28,29]. The effect of ChT and CRT was evaluated by the reduction of tumor size before and after treatment, calculated as (tumor area (mm 2 ) before treatment À tumor area (mm 2 ) after treatment)/(tumor area (mm 2 ) before treatment).…”