Correlation between Hepatitis B Virus Genotypes and Clinical Outcomes

Shi, Yingying

doi:10.7883/yoken.65.476

Cited by 68 publications

(58 citation statements)

References 56 publications

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“…Genotype B and C are restricted to Oceania and Asia, whereas genotype A and D are omnipresent but most common in Africa and Europe (25). Genotype I is unusual and can be observed in Vietnam, Laos, India and China, while genotype J has been reported in Japan and Ryukyu (26,27). Other genotypes such as E, F, G, and H are also occasionally found in Asia.…”

Section: Hbv Genotypingmentioning

confidence: 99%

Diagnosis of hepatitis B

Song

Kim

2016

Ann. Transl. Med.

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Hepatitis B virus (HBV) infection is a major global health problems leading to severe liver disease such as cirrhosis and hepatocellular carcinoma (HCC). HBV is a circular, partly double-stranded DNA virus with various serological markers: hepatitis B surface antigen (HBsAg) and anti-HBs, anti-HBc IgM and IgG, and hepatitis B e antigen (HBeAg) and anti-HBe. It is transmitted by sexual, parenteral and vertical route. One significant method to diminish the burden of this disease is timely diagnosis of acute, chronic and occult cases of HBV. First step of HBV diagnosis is achieved by using serological markers for detecting antigens and antibodies. In order to verify first step of diagnosis, to quantify viral load and to identify genotypes, quantitative or qualitative molecular tests are used. In this article, the serological and molecular tests for diagnosis of HBV infection will be reviewed.

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Section: Hbv Genotypingmentioning

confidence: 99%

Diagnosis of hepatitis B

Song

Kim

2016

Ann. Transl. Med.

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“…Genotypes A and D are ubiquitous but most prevalent in Europe and Africa; genotypes B and C are confined to Asia and Oceania [3,4]. Infections with other genotypes such as E, F, G and H are also occasionally observed in Asia.…”

Section: Epidemiological Relevance Of Hbv Genotypes In Asiamentioning

confidence: 99%

“…Infections with other genotypes such as E, F, G and H are also occasionally observed in Asia. Though rare, genotype I can be found in Laos, Vietnam, India and China [3,[5][6][7]. Genotype J has been described in Japan and Ryukyu [3].…”

Section: Epidemiological Relevance Of Hbv Genotypes In Asiamentioning

confidence: 99%

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Hepatitis B virus genotypes: epidemiological and clinical relevance in Asia

Tian

Jia

2016

Hepatol Int

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Hepatitis B virus (HBV) is characterized by a high genetic heterogeneity since it replicates via a reverse transcriptase that lacks proofreading ability. Up to now, ten genotypes (A-J) have been described, with genotype A and D being ubiquitous but most prevalent in Europe and Africa, genotype B and C being confined to Asia and Oceania. Infections with other genotypes such as E, F, G and H are also occasionally observed in Asia. Genotype I is rare and can be found in Laos, Vietnam, India and China, whereas genotype J has been described in Japan and Ryukyu. Novel variants generated by recombination and co-infection with other genotypes have gradually gotten worldwide attention and may be correlated with certain clinical features. There are substantial differences in HBV infection regarding prevalence, clinical manifestation, disease progression and response to antiviral therapy. Due to the complex interplay among viral, host and environmental factors, the relationship between HBV genotypes and clinical profiles remains incompletely revealed. In general, genotype A is associated with better response to interferon therapy; genotype C, and to lesser extent B, usually represent a risk factor for perinatal infection and are associated with advanced liver diseases such as cirrhosis and hepatocellular carcinoma; genotype D may be linked with poor response to interferon therapy. Future studies with better design and larger sample size are warranted to further clarify the controversial issues and guide the day-to-day clinical practice.

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“…Types C and D may be related to poor clinical outcomes [47]. Some mutations are also linked to severe chronic hepatitis, hepatocellular carcinoma, fulminant hepatitis and resistance to treatment [13,[48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants

López¹,

Flichman

Mojsiejczuk

et al. 2015

Arch Virol

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Hepatitis B virus (HBV) infection is a serious global health problem. Approximately 2 billion people worldwide have been infected, and approximately 350 million individuals currently suffer from HBV-induced chronic liver infection, which causes 600,000 deaths annually from chronic hepatitis, cirrhosis and hepatocellular carcinoma. HBV is classified in eight genotypes (A-H), and two more have been proposed (I-J). In this paper, complete genome sequences of nine Uruguayan HBV are reported. Five samples belong to genotype F1b and one to genotype A2. Three HBV recombinants were detected: A1/F1b, A2/F1b and D3/F1b. The following mutations were detected: a G1896A substitution, a 33-nucleotide deletion from position 2896 to 2928 in the Pre-S1 region involving Pre-S1 residues 3-13, a 33-nt deletion in the Pre-S1 region involving nt 2913-2945 and Pre-S1 residues 9-19. More F genotypes strains than expected were detected in this study, supporting the hypothesis that there are more people of indigenous origin than declared in our population. Also, one third of the samples analyzed were recombinants. This cannot be explained by the low HBV prevalence in Uruguay, but a high HBV infection rate in drug addicts and dialysis patients could act in favor of multiple-genotype HBV infections that could lead to recombination.

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Correlation between Hepatitis B Virus Genotypes and Clinical Outcomes

Cited by 68 publications

References 56 publications

Diagnosis of hepatitis B

Diagnosis of hepatitis B

Hepatitis B virus genotypes: epidemiological and clinical relevance in Asia

Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants

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