Correlation Between Hemorheologic Parameters and Carotid Atherosclerosis in Stroke

Abstract

An evaluation of the hemorheologic parameters and an ultrasonographic study of the extracranial carotid tract were performed on 48 patients, age range: sixty to seventy-five years, affected by acute stroke, 23 of whom had hypertension, while 27 were smokers. None of them was suffering from hyperli pidemia, diabetes mellitus, or symptomatic coronary heart or peripheral artery disease. The echotomographic analysis, using B-mode real-time echotomography re vealed atherosclerotic lesions in 26 patients. The hemorheologic pattern (hema tocrit, fibrinogen, whole blood filterability, whole blood and plasma viscosity) was determined in all the patients three months after the clinical event. Statistical analysis of the results indicates a possible link between athero sclerotic lesions of the extracranial carotid tract and age, fibrinogen levels, and whole blood filterability.

A Study of Thrombogenesis in Atrial Fibrillation and Left Ventricular Dysfunction

“…There is also evidence of a link between these haemorheological parameters in cerebrovascular disease and histopathological evidence of atherosclerotic lesions associated with stroke. When patients with stroke were studied, an association between atherosclerotic lesions of the extracranial carotid artery and age, plasma fibrinogen and whole blood filterability was noted (Mercuri et al 1989). In addition, an elevated plasma fibrinogen predicted the progression of atherosclerotic carotid stenosis (Grotta et al 1989).…”

Research on a method for automated measurement of red cell deformability

“…The deformation of red cells can directly affect the dynamics of blood flow. It may cause the generation of a thrombus or the obstruction of a blood vessel, which is associated with many human diseases such as diabetes mellitus [1], sepsis [2], malaria [3], arteriosclerosis, myocardial [4], cerebrovascular infarction [5], schizophrenia [6,7] and zinc deficiency [8]. Therefore, red cell deformability is a key biochemical indicator [9].…”