Correlation Between HDL-Cholesterol Level and Angiographic Severity of Coronary Artery Disease and It’s Comparison in Patients With and Without Type 2 Diabetes Mellitus

Abstract

BACKGROUNDThere has been enough evidence that HDL cholesterol plays a major role in reverse cholesterol transport and thereby reduces coronary artery atherosclerotic plaque burden and quantitatively low HDL cholesterol increases coronary artery plaque burden. Recent evidence suggests that in diabetic patients, there is functional impairment in HDL cholesterol which increases the risk of coronary artery disease.So, the present study is conducted in order to compare the severity between diabetic and non-diabetic group of patients with coronary artery disease and to correlate with HDL-C values.The objectives of the study were to study the correlation between quantitative HDL cholesterol level and angiographic severity of coronary artery disease and to compare these findings between diabetic and non-diabetic group of patients. MATERIALS AND METHODS90 Patients with acute ST segment elevation myocardial infarction diagnosed on ECG findings and admitted in ICCU of KIMS Hospital, of which 45 patients had diabetes mellitus.Based on angiographic findings, coronary artery disease severity was calculated using revised BCIS-1 Jeopardy score, and the data obtained was analysed by different statistical methods. RESULTSOut of 90 patients in the study, Mean HDL-C in patients with and without T2DM was 44 mg/dl and 43 mg/dl respectively (p value 0.47). In non-diabetic patients HDL-C was negatively correlated to BCIS1 Jeopardy score (r=0.65, p<0.001). In patients with T2DM there was a positive correlation between HDL-C and BCIS1 Jeopardy score (r=0.38, p= 0.01). CONCLUSIONFrom this study we can conclude that HDL-C though is thought to be protective cholesterol, appears to be appropriate in patients without T2DM. In patients with poorly controlled T2DM, HDL C levels does not show protective role in our study. This could be attributed to the functional impairment of HDL-C in patients with poorly controlled diabetes mellitus. KEYWORDSST Elevation MI; Type 2 Diabetes Mellitus; HDL-Cholesterol. HOW TO CITE THIS ARTICLE:Bande US, Renukappa VB. Correlation between HDL-cholesterol level and angiographic severity of coronary artery disease and it's comparison in patients with and without type 2 diabetes mellitus.