Correlation Between Hashimoto's Thyroiditis–Related Thyroid Hormone Levels and 25-Hydroxyvitamin D

Chao, Guanqun; Zhu, Yimin; Fang, Lizheng

doi:10.3389/fendo.2020.00004

Cited by 40 publications

(50 citation statements)

References 25 publications

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“…The most similar study to ours, by sample size and result, was reported by Kim et al [ 47 ] who observed a significant negative correlation between vitamin D and serum TSH in the group of 369 AITD patients and 407 controls after adjustment for sample season, age, sex, and BMI (r = −0.127, p = 0.013). Chao et al [ 28 ] also observed a negative correlation and a similar effect to ours between vitamin D and TSH in 5230 participants, of which 373 were HT cases.…”

Section: Discussionsupporting

confidence: 86%

“…The next important observation of our study is a nominally significant weak negative correlation between vitamin D levels and TSH in all HT patients ( Table 4 ). The majority of studies observed significant associations between vitamin D deficiency and TSH values in HT patients or weak negative correlations between vitamin D levels and TSH [ 28 , 46 , 47 , 48 ]. The most similar study to ours, by sample size and result, was reported by Kim et al [ 47 ] who observed a significant negative correlation between vitamin D and serum TSH in the group of 369 AITD patients and 407 controls after adjustment for sample season, age, sex, and BMI (r = −0.127, p = 0.013).…”

Section: Discussionmentioning

confidence: 99%

“…Since then, a large number of studies tried to clarify the association of vitamin D with HT by analyzing differences in vitamin D levels between HT cases and control participants, but without reaching consistent results. The most recent study found lower vitamin D levels in 373 HT cases in comparison to 4889 control participants who had vitamin D measured at the same time; however, after performing multivariate logistic regression the study concluded that vitamin D was not associated with HT [ 28 ]. Another recent systematic review, meta-analysis and meta-regression of observational studies [ 29 ] reported a significant association between vitamin D status and HT, suggesting that HT patients have lower serum 25(OH)D concentrations than those without HT.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D and Hashimoto’s Thyroiditis: Observations from CROHT Biobank

et al. 2021

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The aims of this study were to evaluate: (1) associations of vitamin D with the presence/severity of Hashimoto’s thyroiditis (HT) and (2) correlations of vitamin D with thyroid-related phenotypes. Total 25(OH)D (vitamin D in the text) was measured from stored serum samples of 461 HT patients and 176 controls from a Croatian Biobank of HT patients (CROHT). (1) Vitamin D levels, and proportions of vitamin D deficiency, were compared between HT cases and controls. HT patients were additionally divided into two groups (MILD and OVERT) to take into account HT severity. (2) Correlations between vitamin D and 10 clinical phenotypes in all HT patients and two subgroups of HT patients were tested using the Spearman correlation test. Our analyses were adjusted for age, gender, BMI, smoking status and seasonality of blood sampling. (1) No significant differences in vitamin D levels, or proportions of vitamin D deficiency, were detected between HT patients of all disease stages and controls. However, a nominally significant difference in vitamin D levels between MILD and OVERT subgroups (OR = 1.038, p = 0.023) was observed. Proportions of individuals with vitamin D deficiency during winter–spring were high: all HT cases (64.69%), MILD (60.64%), OVERT (68.7%), controls (60.79%). (2) A nominally significant negative correlation between vitamin D and TSH in all HT patients (r = −0.113, p = 0.029) and a positive correlation between vitamin D and systolic blood pressure in OVERT HT patients (r = 0.205, p = 0.025) were identified. Our study indicates that there is no association between vitamin D and HT; however, there may be a subtle decrease in vitamin D levels associated with overt hypothyroidism.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D and Hashimoto’s Thyroiditis: Observations from CROHT Biobank

et al. 2021

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“…A meta-analysis [including 6/3 studies with continuous/dichotomous 25(OH)D levels] showed that HT patients had lower values compared to controls, and more likely have 25(OH)D deficiency ( Wang et al, 2015 ). Moreover, data on the inverse correlation between vitamin D values with thyroid volume, and duration and severity of HT, and TH and thyroid antibody levels further reinforcing the idea that vitamin D deficiency might play a role in the risk, onset and development of HT ( Muscogiuri et al, 2016 ; Chao et al, 2020 ).…”

Section: Vitamin D and Thyroid Pathophysiologymentioning

confidence: 69%

Vitamin D, Thyroid Hormones and Cardiovascular Risk: Exploring the Components of This Novel Disease Triangle

et al. 2021

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The role of thyroid hormones (THs) in the cardiovascular (CV) system, through several direct and indirect effects is recognized. Even very small modification in TH levels (as those observed in subclinical hypothyroidism or hyperthyroidism, and low triiodothyronine syndrome) may adversely affect the CV system, whereas thyroid hormones benefit the CV system and improve the prognosis. There is also evidence of vitamin D effects on cardiometabolic disease (e.g., through modulation of endothelial and smooth muscle cell activity, renin-angiotensin-aldosterone system, nitric oxide, oxidative stress, and inflammatory response), as well as an association between vitamin D [25(OH)D] deficiency and autoimmune thyroid diseases or cancer, and a relationship between vitamin D concentration and titers of antibodies and thyroid autoimmunity replacement. Interestingly, experimental data indicate a direct effect of vitamin D on Type 2 deiodinase expression causing subsequential peripheral conversion of T4 into T3. However, the functional links among THs, vitamin D and the cardiovascular system, and clinical effects of coexisting abnormalities in this new troublesome triad, have not yet been reviewed. The main aim of this review is to discuss pathophysiology of this relationship, proposing new mechanistic insights involving vitamin D in the modulation of cardiometabolic disease and thyroid profile.

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“…Vitamin D has been found to play an increasingly crucial regulatory role in bone metabolism, the mucosal barrier, and the immune system in the past few decades. More recently, numerous studies have highlighted that an insufficient level of 25-hydroxyvitamin D [25(OH)D] is significantly associated with HT 123 - 125 .…”

Section: Treatments For Ht-related Miscarriagementioning

confidence: 99%

The exploration of Hashimoto's Thyroiditis related miscarriage for better treatment modalities

Min¹,

Wang²,

Chen³

et al. 2020

Int. J. Med. Sci.

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Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disease (ATD) worldwide and is strongly associated with miscarriage and even recurrent miscarriage (RM). Moreover, with a deepening understanding, emerging evidence has shown that immune dysfunctions caused by HT conditions, including imbalanced subsets of CD4+ T-helper cells, B regulatory (Breg) cells, high expression levels of CD56dim natural killer (NK) cells, and cytokines, possibly play an important role in impairing maternal tolerance to the fetus. In recent years, unprecedented progress has been made in recognizing the specific changes in immune cells and molecules in patients with HT, which will be helpful in exploring the mechanism of HT-related miscarriage. Based on these findings, research investigating some potentially more effective treatments, such as selenium (Se), vitamin D3, and intravenous immunoglobulin (IVIG), has been well developed over the past few years. In this review, we highlight some of the latest advances in the possible immunological pathogenesis of HT-related miscarriage and focus on the efficacies of treatments that have been widely introduced to clinical trials or practice described in the most recent literature.

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Correlation Between Hashimoto's Thyroiditis–Related Thyroid Hormone Levels and 25-Hydroxyvitamin D

Cited by 40 publications

References 25 publications

Vitamin D and Hashimoto’s Thyroiditis: Observations from CROHT Biobank

Vitamin D and Hashimoto’s Thyroiditis: Observations from CROHT Biobank

Vitamin D, Thyroid Hormones and Cardiovascular Risk: Exploring the Components of This Novel Disease Triangle

The exploration of Hashimoto's Thyroiditis related miscarriage for better treatment modalities

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