Correlation between gut bacteria Phascolarctobacterium and exogenous metabolite α-linolenic acid in T2DM: a case-control study

Li, Weidong; Li, Lisha; Yang, Fu-Jie; Hu, Quan; Xiong, Daqian

doi:10.21037/atm-22-3967

Cited by 18 publications

(9 citation statements)

References 30 publications

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“…In relation to the correlation of some nutrients with specific genera, we can observe that in the study of olive oil consumption, we found a positive correlation with genera that have been seen to be found with a lower abundance in certain diseases such as inflammatory bowel disease, hypercholesterolaemia, gastric cancer, or type II diabetes mellitus [ 19 , 55 , 65 , 66 , 67 , 68 , 69 ]. This suggests that these microorganisms are markers of good health status.…”

Section: Discussionmentioning

confidence: 85%

“…In relation to the intake of NSPs, we found a positive correlation of genera such as Lactococcus , Victivallis , Anaerofustis , Senegalimassilia , and Phascolarctobacterium , which are related to SCFA production, good health status, and higher longevity [ 63 , 67 , 69 , 74 ]. However, Finegoldia and Peptoniphilus are also associated with inflammatory processes and the presence of conventional adenomas [ 75 , 76 ].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, concerning the genera that correlated positively with red meat consumption, we found genera related to inflammatory bowel disease, such as Faecalicoccus and Clostridium sensu stricto [ 62 , 63 ]; Anaerofustis , which is related to ulcerative colitis but also to greater longevity [ 63 , 83 ]; and other genera that are more related to a good state of health, such as Phascolarctobacterium and Subdoligranulum [ 69 , 84 ]. The genera found to be inversely correlated with red meat consumption were mostly related to anti-inflammatory function, protection against some types of cancer, or low risk of celiac disease [ 82 , 85 , 86 ].…”

Section: Discussionmentioning

confidence: 99%

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Impact of the Mediterranean Diet on the Gut Microbiome of a Well-Defined Cohort of Healthy Individuals

Vázquez-Cuesta,

Lozano García,

Rodríguez-Fernández

et al. 2024

Nutrients

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A comprehensive understanding of gut microbiota in a clearly defined group of healthy individuals is essential when making meaningful comparisons with various diseases. The Mediterranean diet (MD), renowned for its potential health benefits, and the influence of adherence thereto on gut microbiota have become a focus of research. Our aim was to elucidate the impact of adherence to the MD on gut microbiota composition in a well-defined cohort. In this prospective study, healthy volunteers completed a questionnaire to provide demographic data, medical history, and dietary intake. Adherence was evaluated using the Med-DQI. The V4 region of the 16S rRNA gene was sequenced. Analysis of sequencing data and statistical analysis were performed using MOTHUR software and R. The study included 60 patients (51.7% females). Adherence correlated with alpha diversity, and higher values were recorded in good adherers. Good adherers had a higher abundance of Paraprevotella and Bacteroides (p < 0.001). Alpha diversity correlated inversely with fat intake and positively with non-starch polysaccharides (NSPs). Evenness correlated inversely with red meat intake and positively with NSPs. Predicted functional analysis highlighted metabolic pathway differences based on adherence to the MD. In conclusion, our study adds useful information on the relationship between the MD and the gut microbiome.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impact of the Mediterranean Diet on the Gut Microbiome of a Well-Defined Cohort of Healthy Individuals

Vázquez-Cuesta,

Lozano García,

Rodríguez-Fernández

et al. 2024

Nutrients

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“…33 Phascolarctobacterium is associated with alpha-linolenic acid, which better promotes the repair of metabolic disorders and increases the abundance of beneficial intestinal bacteria. 34 After all, supplementation, mainly FSM4, may be achieved by increasing the healthy bacteria, promoting the production of functional metabolites for suppressing inflammation to alleviate diarrhea. With respect to the microbiome, soy compounds, including proteins, small peptides, and polyphenols (isoflavones), can regulate the balance of gut microbiota, restore healthy gut bacteria, and reduce the colonization of intestinal pathogenic bacteria.…”

Section: Discussionmentioning

confidence: 99%

Promising probiotic-fermented soymilk for alleviating acute diarrhea: insights into the microbiome and metabolomics

Madjirebaye,

Peng,

Mueed

et al. 2024

Food Funct.

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“…What’s more, the components in serum are supposed to affect the types and numbers of intestinal flora [ 31 ]. And it is feasible to affect the types and numbers of intestinal flora by using natural products to alleviate or treat diseases [ 32 ]. Therefore, in this study, we focus on the intestinal flora and metabolites to study the therapeutic effect of A. lancea on GI diseases and explore its underlying mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Effects of Atractylodes lancea extracts on intestinal flora and serum metabolites in mice with intestinal dysbacteriosis

Zhang

Tian

et al. 2023

Proteome Sci

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Objective This study aims to explore the effect of an extract of Atractylodes lancea (A. lancea) on antibiotics-induced intestinal tract disorder and the probable therapeutic mechanisms employed by this extract to ameliorate these disorders. Methods Three days after acclimatization, nine male and nine female specific-pathogen-free (SPF) mice were randomly assigned into three groups: Group C (normal saline), Group M (antibiotic: cefradine + gentamicin), and Group T (antibiotic + A. lancea extract). Each mouse in Groups M and T received intragastric (i.g.) gavage antibiotics containing cefradine and gentamicin sulfate (0.02 ml/g−1/D−1) for 7 days. A. lancea extract (0.02 ml/g−1/D−1) was administered by i.g. gavage to Group T mice for 7 days following the cessation of antibiotic therapy. Group M received an equivalent volume of normal saline for 7 days, while Group C received an equivalent volume of normal saline for 14 days. Afterwards, we collected mouse feces to assess changes in intestinal microbiota by 16S ribosomal ribonucleic acid (rRNA) sequencing and metabolomics. In addition, serum samples were gathered and analyzed using liquid chromatography–mass spectrometry (LS-MS). Finally, we performed a correlation analysis between intestinal microbiota and metabolites. Results After treatment with antibiotic, the richness and diversity of the flora, numbers of wall-breaking bacteria and Bacteroidetes, and the numbers of beneficial bacteria decreased, while the numbers of harmful bacteria increased. After i.g. administration of A. lancea extract, the imbalance of microbial flora began to recover. Antibiotics primarily influence the metabolism of lipids, steroids, peptides, organic acids, and carbohydrates, with lipid compounds ranking first. Arachidonic acid (AA), arginine, and proline have relatively strong effects on the metabolisms of antibiotic-stressed mice. Our findings revealed that A. lancea extract might restore the metabolism of AA and L-methionine. The content of differential metabolites detected in the serum of Group T mice was comparable to that in the serum of Group C mice, but significantly different from that of Group M mice. Compared to putative biomarkers in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, it was found that altered metabolites, such as amino acids, glycerol, and phospholipids, were primarily associated with the metabolism. Conclusions The effective mechanisms of A. lancea extract in regulating the disorder of intestinal flora in mice are related to the mechanisms of A. lancea. It could relate to lipid metabolism, bile acid metabolism, and amino acid metabolism. These results will provide a basis for further explaining the mechanism by which A. lancea regulats intestinal flora.

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Correlation between gut bacteria Phascolarctobacterium and exogenous metabolite α-linolenic acid in T2DM: a case-control study

Abstract: Contributions: (I) Conception and design: Q Hu; (II) Administrative support: D Xiong; (III) Provision of study materials or patients: L Li; (IV)

Cited by 18 publications

References 30 publications

Impact of the Mediterranean Diet on the Gut Microbiome of a Well-Defined Cohort of Healthy Individuals

Impact of the Mediterranean Diet on the Gut Microbiome of a Well-Defined Cohort of Healthy Individuals

Promising probiotic-fermented soymilk for alleviating acute diarrhea: insights into the microbiome and metabolomics

Effects of Atractylodes lancea extracts on intestinal flora and serum metabolites in mice with intestinal dysbacteriosis

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