Correlation between glycemic control, lipid profile and C-reactive protein in adults with type 2 diabetes mellitus done in a tertiary care hospital of Nellore, Andhra Pradesh, India

Abstract

Background: Diabetes mellitus refers to a group of common metabolic disorders that shares the phenotype of hyperglycemia. Complications of diabetes mellitus involve many organ systems only to play an important role in morbidity and mortality. Poor glycemic control is significantly associated with the development of macrovascular complications. Earlier studies have indicated that C-reactive protein (CRP) is an important risk factor for cardiovascular disease as evident from its higher levels in people with diabetes mellitus compared to those without. Not much is known whether CRP is related to the level of glycemic control. The purpose of this study is, to determine the relation between HbA1C, Lipid profile and CRP in individuals with type 2 diabetes mellitus.Methods: Fifty patients with T2DM reporting to Narayana Medical College and Hospital were included in the study, in whom CRP levels were estimated by using commercially available kits and correlated with HbA1C and other risk factors of coronary artery disease. Follow-up was done on 20 patients who were not on statin therapy with repeat HbA1C and CRP.Results: This study showed that both HbA1C and CRP levels had reduced significantly in follow-up patients after putting them on treatment (p<0.05). It was also found that lower the HbA1C, lower was the CRP. A positive correlation was found between HbA1C and CRP (p<0.05).Conclusions: In this study of 50 patients with T2DM, it was found that CRP is significantly correlated with HbA1C level. A positive correlation was found between serum CRP and HbA1C in the initial group and in the follow-up patients, showing that CRP levels lowers with better glycemic control and correlates with dyslipidaemia profile.

Association between high-sensitivity C-reactive protein and lipid profile in patients with type 2 diabetes mellitus

“…In the current investigation, we also noticed that patients with T2DM had significantly higher levels of hs-CRP, with a mean value of 2.49 ± 1.15mg/L compared to controls, who had a mean value of 1.22 ± 0.54mg/L (p<0.001) [Table 6]. Our research findings are consistent with those of Pfutzner and Forst (2006) and Stehouwer et al (2002) [36,37].…”