Correlation between gastric emptying time and the response of pancreatic polypeptide to test meals in peptic ulcer diseases.

Koizumi, Fumiaki; Kawamura, Takeshi; Ishimori, Akira; Ebina, Hirotaka; Satoh, Michinori

doi:10.1620/tjem.151.275

Cited by 4 publications

(2 citation statements)

References 15 publications

(18 reference statements)

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“…1, the plasma acetami nophen concentration in a control study was increased time dependently and peaked at 45 min (6.9 ± 1.2,ug/ml) after the acetami nophen administration. Our results were con sistent with those reported by Koizumi et al who measured gastric emptying in dogs by the acetaminophen method (14). This means that the food containing acetaminophen was grad ually emptied from the stomach, and acetami nophen was absorbed in the small intestine.…”

Section: Gastric Emptying In the Dogsupporting

confidence: 91%

Stimulatory Effect of N-(4-(2-(Dimethylamino)-ethoxy)benzyl)-3,4-Dimethoxybenzamide Hydrochloride(HSR-803)on Normal and Delayed Gastrointestinal Propulsion.

et al. 1991

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ABSTRACT-To estimate the effect of a new gastroprokinetic agent, N-[4-[2 (dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803), on non-ulcer dyspepsia, the influence of HSR-803 on gastrointestinal propulsion was assayed in dogs, rats and mice in comparison with some gastroprokinetic agents. HSR-803 (30 mg/kg, p.o.) significantly enhanced gastric emptying in dogs, and it sig nificantly improved the delayed gastric emptying induced by dopamine (0.4 mg/kg, i.p.) and morphine (1 mg/kg, s.c.) in rats. Metoclopramide (30 mg/kg, p.o.) also sig nificantly restored the dopamine-induced delay, but at a dose of 10 mg/kg, p.o., it en hanced the morphine-induced delay in gastric emptying in rats. HSR-803 (10 100 mg/kg, p.o.) increased small intestinal transit in mice in a dose-dependent manner, and the effect was abolished by atropine (0.3 mg/kg, i.p.). Metoclopramide also in creased small intestinal transit, but domperidone and cisapride had no effect. In de layed small intestinal transit in mice, HSR-803 (10-100 mg/kg, p.o.) improved the morphine (0.3 mg/kg, s.c.)-induced delay in a dose-dependent manner. In conclusion, because of the promotion of normal and delayed gastrointestinal propulsion, HSR-803 seems to be a promising gastroprokinetic agent for the treatment of non-ulcer dyspep sia. The action of HSR-803 is likely to be exerted through cholinergic stimulation.It has been reported that a new gastropro kinetic agent, HSR-803, stimulates gastrointes tinal motility in conscious dogs, probably through dopamine D2 receptor (D2) blocking and anti-acetylcholinesterase (anti-AChE) ac tivities (1). Several gastroprokinetic agents, metoclopramide and domperidone are known to be D2 antagonists, and reported to have weak anti-AChE activity (1-3). A newly de veloped gastroprokinetic agent, cisapride, also has an anti-D2 action (4). The D2 blocking activity of HSR-803 was weaker than that of metoclopramide, domperidone and cisapride, while anti-AChE activity was more potent than that of metoclopramide and domperidone (5). Thus the pharmacological profile of HSR 803 was expected to differ from that of meto clopramide and domperidone.One of, the gastrointestinal disorders, non ulcer dyspepsia having symptoms of discom fort in the epigastrium, fullness in the abdo men, nausea and emesis is mainly due to de

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Section: Gastric Emptying In the Dogsupporting

confidence: 91%

Stimulatory Effect of N-(4-(2-(Dimethylamino)-ethoxy)benzyl)-3,4-Dimethoxybenzamide Hydrochloride(HSR-803)on Normal and Delayed Gastrointestinal Propulsion.

et al. 1991

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“…In the present study, however, diabetic hyperglycemia was not correlated with delayed gastric emptying. Furthermore, it was reported that gastric emptying in STZ-induced diabetic gastroparetic dogs did not improve with control of blood glucose by insulin [25].…”

Section: Discussionmentioning

confidence: 99%

Gastric Emptying in Diabetic Gastroparetic Dogs: Effects of SK-951,a Novel Prokinetic Agent

Takeda

Mizutani²,

Yamano³

et al. 2001

Pharmacology

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We examined whether delayed gastric emptying could be produced by diabetes in dogs. Diabetes was produced by a single injection of streptozotocin (30 mg/kg i.v.), and diabetic hyperglycemia was observed from 2 to 15 months after injection. The plasma acetaminophen concentration, which is an indirect indicator of the gastric emptying rate, was delayed in 2 of 5 diabetic dogs from 15 months after the induction of diabetes. The effects of SK-951, a benzofuran derivative, on delayed gastric emptying were also examined in diabetic gastroparetic dogs in comparison with those of cisapride. SK-951 (1 mg/kg i.v.) significantly enhanced delayed gastric emptying in diabetic dogs, but cisapride (1 mg/kg i.v.) had no effect. In addition, SK-951 increased the plasma glucose levels in a manner correlated with its effect on gastric emptying. The present study suggested that SK-951 may be useful in the treatment of diabetic gastroparesis.

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Effect of motilin on gastric emptying in patients with diabetic gastroparesis

et al. 1992

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Correlation between gastric emptying time and the response of pancreatic polypeptide to test meals in peptic ulcer diseases.

Cited by 4 publications

References 15 publications

Stimulatory Effect of N-(4-(2-(Dimethylamino)-ethoxy)benzyl)-3,4-Dimethoxybenzamide Hydrochloride(HSR-803)on Normal and Delayed Gastrointestinal Propulsion.

Stimulatory Effect of N-(4-(2-(Dimethylamino)-ethoxy)benzyl)-3,4-Dimethoxybenzamide Hydrochloride(HSR-803)on Normal and Delayed Gastrointestinal Propulsion.

Gastric Emptying in Diabetic Gastroparetic Dogs: Effects of SK-951,a Novel Prokinetic Agent

Effect of motilin on gastric emptying in patients with diabetic gastroparesis

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