Correlation between Galectin-3 and Early Herpes Zoster Neuralgia and Postherpetic Neuralgia: A Retrospective Clinical Observation

Wang, Tingting; Fei, Yong; Yao, Ming; Tao, Jiachun; Deng, Jiajia; Huang, Bing

doi:10.1155/2020/8730918

Cited by 12 publications

(13 citation statements)

References 29 publications

(27 reference statements)

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“…The genetic polymorphisms of the galectin-3-encoding gene affected the course of enterovirus 71 infection in children, which was partially associated with diverse viral replication according to the gene variant [33]. Increased serum galectin-3 has been observed in patients with varicella-zoster virus infection and patients with herpes zoster neuralgia and post-herpetic neuralgia presented with higher concentrations [17]. In human immunodeficiency virus infection, galectin-3 has been shown to support the attachment of the virus to macrophages and CD4+ T cells [19,34].…”

Section: Discussionmentioning

confidence: 99%

“…Galectin-3 is released by inflammatory cells, mainly macrophages, endothelial cells, and epithelial cells. It is found in spleen, stomach, colon, liver, kidney, heart, uterus, ovary, pancreas, and lungs (alveolar cells) [15,17]. Galectin-3 has been previously studied in relation to several viral infections in human, including human immunodeficiency virus, herpesvirus-1 infection, influenza, early herpes zoster neuralgia, and postherpetic neuralgia [15,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…The proinflammatory action of galectin-3 is associated with the activation of the transcription factor NF-κB and induction of tumor necrosis factor α (TNF-α) and IL-6, regulation of cell adhesion, promotion of cell activation and chemotaxis, and regulation of cell growth and apoptosis [17,21,22]. In severe COVID-19, the systemic hyperinflammation with the cytokine storm has been implicated as a cause of respiratory failure and other organs' injury [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Significance of Serum Galectin-3 in Hospitalized Patients with COVID-19—A Preliminary Study

et al. 2021

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Severe coronavirus disease 2019 (COVID-19) is associated with hyperinflammation leading to organ injury, including respiratory failure. Galectin-3 was implicated in innate immunological response to infections and in chronic fibrosis. The aim of our preliminary study was the assessment of the diagnostic utility of serum galectin-3 in patients with COVID-19. The prospective observational study included adult patients admitted with active COVID-19 and treated in tertiary hospital between June and July 2020. The diagnosis was confirmed by the quantitative detection of nucleic acid of severe acute respiratory syndrome coronavirus 2 in nasopharyngeal swabs. Galectin-3 was measured by enzyme immunoassay in serum samples obtained during the first five days of hospital stay. We included 70 patients aged 25 to 73 years; 90% had at least one comorbidity. During the hospital stay, 32.9% were diagnosed with COVID-19 pneumonia and 12.9% required treatment in the intensive care unit (ICU). Serum galectin-3 was significantly increased in patients who developed pneumonia, particularly those who required ICU admission. Positive correlations were found between galectin-3 and inflammatory markers (interleukin-6, C-reactive protein, ferritin, pentraxin-3), a marker of endothelial injury (soluble fms-like tyrosine kinase-1), and a range of tissue injury markers. Serum galectin-3 enabled the diagnosis of pneumonia with moderate diagnostic accuracy and the need for ICU treatment with high diagnostic accuracy. Our findings strengthen the hypothesis that galectin-3 may be involved in severe COVID-19. Further studies are planned to confirm the preliminary results and to verify possible associations of galectin-3 with long-term consequences of COVID-19, including pulmonary fibrosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic Significance of Serum Galectin-3 in Hospitalized Patients with COVID-19—A Preliminary Study

et al. 2021

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“…Our previous research results also revealed that in PHN patients, Gal-3 and IL-6 plasma levels were considerably higher than in normal people [12]. It can be used as an early diagnosis and a predictor of PHN [24]. In this study, it was found that Gal-3 and IL-6 levels in the patients' plasma in the group of internal heat acupuncture combined with high-voltage long-duration PRF decreased significantly at 4 and 12 weeks after treatment, implying that the effect of internal heat acupuncture on eliminating skin nerve endings inflammation was more lasting.…”

Section: Discussionmentioning

confidence: 76%

Efficacy of Internal Heat Acupuncture Combined with High-Voltage Long-Duration Pulsed Radiofrequency on Subacute Postherpetic Neuralgia: A Retrospective Study

Fei

Yao

Huang

et al. 2022

Pain Research and Management

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Objectives. This study aims at investigating the internal heat acupuncture (IHA) combined with the high-voltage long-duration pulsed radiofrequency (PRF) therapeutic effect on subacute postherpetic neuralgia (PHN). Methods. This retrospective study comprised 81 cases with PHN. They were divided into three groups: IHA combined with the high-voltage long-duration PRF group (IHA-PRF), intradermal injection combined with the high-voltage long-duration PRF group (II-PRF), and the high-voltage long-duration PRF group. The pain numerical rating score (NRS), IL-6, Gal-3, and blood glucose levels were recorded before and after treatment. Results. Compared with before treatment, NRS scores of the three groups were all decreased at each time point. NRS scores of the IHA-PRF group patients decreased significantly in comparison to the PRF group at 1, 4, 8, and 12 weeks following treatment, while group II-PRF only decreased significantly at one week following treatment. Compared with groups II-PRF and PRF, respectively, IL-6 and Gal-3 levels in plasma of patients in group IHA-PRF were significantly decreased at 4 and 12 weeks after treatment. The effective rate of group IHA-PRF was 88.9%, which was considerably more than the other groups, II-PRF (63.0%) and PRF (63.0%). Compared with group II-PRF, patients’ blood glucose levels in IHA-PRF and PRF groups significantly decreased three days and one week after treatment. Conclusion. Internal heat acupuncture combined with high-voltage long-duration pulsed radiofrequency has a satisfactory therapeutic effect on subacute PHN and has no obvious adverse reactions, which is especially suitable for patients with poor blood glucose control.

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“…1k ). Importantly, in the context of pain pathogenesis, Gal3 was reported to play a critical role in neuropathic pain in a peripheral nerve injury model 20,21 . Hence, we were interested in validating, at a protein level, Gal3 is a marker for HIPAs.…”

Section: Resultsmentioning

confidence: 99%

A novel subtype of reactive astrocytes critical for HIV associated pain pathogenesis

Zheng

Spurgat

Tang

2022

Preprint

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Pathological pain is common in HIV patients, but the underlying mechanism remains elusive and therapeutic targets for effective treatment have not been identified. Reactive astrocytes are specifically activated in the spinal dorsal horn (SDH) of HIV patients with pathological pain and required for the development of HIV-associated pain in mouse models. These findings suggest a key role of reactive astrocytes in HIV-associated pain pathogenesis. However, due to the heterogeneity of reactive astrocytes, the pathogenic subtype is unknown. Using single-nucleus RNA-seq (snRNA-seq) transcriptomic analysis, we identified a novel subtype of HIV-pain associated astrocytes (HIPAs) in the lumbar spinal cord of the HIV -1 gp120 transgenic model. HIPAs were galectin 3 (Gal3)- positive and had transcriptomic signatures of phagocytosis and inflammation; they were also induced in the spinal cord of HIV patients. We showed HIPAs phagocytosed neuronal and synaptic components and were associated with neuronal degeneration. We found that knockout (KO) of Gal3 in gp120 transgenic mice severely diminished HIPAs. Interestingly, the activation of other astrocytes (e.g., homeostatic astrocytes) were also diminished in the Gla3 KO/gp120 transgenic mice. These results indicate that Gal3 is critical for gp120 to induce HIPAs, and that Gal3 may directly or via HIPAs to control the activation of other subtypes of astrocytes. Finally, we showed that the loss of HIPAs caused by Gal3 KO was associated with attenuated neuronal degeneration, neuroinflammation, and pain in gp120 transgenic mice. Collectively, our data suggest that HIPAs are a Gal3-expressing astrocytic subtype that mediates gp120-induced neurodegeneration and neuroinflammation in the spinal pain neural circuit during pain pathogenesis and is a potential cell target for treating HIV-associated pain.

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Correlation between Galectin-3 and Early Herpes Zoster Neuralgia and Postherpetic Neuralgia: A Retrospective Clinical Observation

Cited by 12 publications

References 29 publications

Diagnostic Significance of Serum Galectin-3 in Hospitalized Patients with COVID-19—A Preliminary Study

Diagnostic Significance of Serum Galectin-3 in Hospitalized Patients with COVID-19—A Preliminary Study

Efficacy of Internal Heat Acupuncture Combined with High-Voltage Long-Duration Pulsed Radiofrequency on Subacute Postherpetic Neuralgia: A Retrospective Study

A novel subtype of reactive astrocytes critical for HIV associated pain pathogenesis

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