Correlation between functional capacity and oxidative stress and inflammation in hemodialysis patients

Silva, Ítalo Caldas; Marizeiro, Débora Fortes; Daher, Elizabeth De Francesco; Sandes‐Freitas, Tainá Veras de; Meneses, Gdayllon Cavalcante; Bezerra, Gabriela Freire; Libório, Alexandre Braga; Martins, Alice Maria Costa; Campos, Nataly Gurgel

doi:10.1016/j.jbmt.2021.01.002

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…The main result is that patients treated with maintenance dialysis self-reported lower physical tness in all assessed components, but exibility, compared with individuals without CKD. The decline in physical tness components in CKD patients reported in the presented study and in others, is related with adverse outcomes, including lower quality of life 13 , higher oxidative stress, a higher degree of in ammation 14 , an increase in hospitalizations 5 and a higher mortality rate 14,15 . Factors such as uremic neuropathy, anemia, heart disease, hypertension, fatigue, depression, and lower limb pain contribute to the observed reduction in physical tness 15,16 15,33 .…”

Section: Discussionsupporting

confidence: 48%

Physical fitness in patients treated with maintenance dialysis: a cross-sectional study

Baptista,

Prado,

Christofaro

et al. 2024

Preprint

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Background: Low physical fitness has been associated with deterioration in overall health outcomes, resulting in increased hospitalization, morbidity, and mortality in patients treated with maintenance dialysis. This study aimed to compare self-reported physical fitness between patients treated with maintenance dialysis and those without chronic kidney disease (CKD). Methods: In this cross-sectional study, patients treated with maintenance dialysis (n=674) and individuals without CKD (control, n=518) self-reported physical fitness by responding to the International Fitness Scale (IFIS). Binary Logistic Regressions were adjusted for sex, age, schooling, diabetes, smoking, physical activity, sedentary behavior, and body max index. Results: Patients undergoing chronic hemodialysis are more likely to self-report lower general PF (OR=2.03; 95% CI: 1.35 to 3.05; p = 0.001), cardiorespiratory fitness (OR=3.18; 95% CI: 2.27 to 4.46; p<0.001), strength (OR=2.51; 95 % CI: 1.71 to 3.68; p<0.001) and agility (OR=1.83; 95% CI: 1.26 to 2.64; p=0.001) than the control group. Patients undergoing chronic hemodialysis who self-reported higher levels of physical activity were 5.64 times more likely to self-report high overall physical fitness (OR=5.64, 95% CI: 1.93 to 16.45, p<0.002). Conclusion: Patients treated with maintenance dialysis were twice as likely to self-report lower general physical fitness compared to individuals without kidney disease. Considering the consequences related to these factors, strategies to improve it, like initiatives related to the practice of physical exercises with this population, including strategically during hemodialysis, may be interesting.

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