Correlation Between Foveal Cone Outer Segment Tips Line and Visual Recovery After Epiretinal Membrane Surgery

Itoh, Yuji; Inoue, Makoto; Rii, Tosho; Hirota, Kazunari; Hirakata, Akito

doi:10.1167/iovs.13-12702

Cited by 102 publications

(98 citation statements)

References 34 publications

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“…[20][21][22] Kim et al reported that the preoperative integrity of foveal photoreceptors may be an important prognostic factor for visual outcome in patients with idiopathic ERM. 20 Itoh et al 21 found that the recovery of the foveal photoreceptor cone outer segment tips line disintegrity is associated with the visual recovery after ERM surgery. In addition, the presence of a preoperative intact IS/OS junction was found to be an important predictor of better visual outcome following ERM surgery.…”

Section: Discussionmentioning

confidence: 99%

Comparison of photoreceptor outer segment length in diabetic and idiopathic epiretinal membranes

Yüksel

Karaküçük

Özkaya

et al. 2015

Eye

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Purpose Idiopathic and diabetic epiretinal membranes (ERMs) differ significantly in terms of macular morphology. Our aim was to compare the photoreceptor outer segment (PROS) length in diabetic and idiopathic ERMs before and after surgery. Methods Fifty-two eyes of 50 patients who underwent pars plana vitrectomy (PPV) due to idiopathic and diabetic ERMs were included in this retrospective case series. All of the patients underwent ERM and internal limiting membrane (ILM) removal. The patients had been followed up 6 months postoperatively. Spectral-domain optical coherence tomography (OCT) was used to measure the PROS length, overall PR length and central foveal thickness (CFT). Results The PROS length, overall PR length, and CFT were statistically significantly lower at all the postoperative visits when compared to preoperative values in both the idiopathic and diabetic ERM groups (Po0.001). The amount of decrease in PROS and overall PR length were similar in both groups after surgery (P40.05). There was no relation between amount of PROS length change and visual acuity gain in both groups (P40.05). Conclusions Postoperative change of PROS length was similar in idiopathic and diabetic ERMs. PROS length change may not be an indicator of postoperative visual acuity.

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Section: Discussionmentioning

confidence: 99%

Comparison of photoreceptor outer segment length in diabetic and idiopathic epiretinal membranes

Yüksel

Karaküçük

Özkaya

et al. 2015

Eye

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“…The diameters of the IS/OS junction defect and ELM defect were measured when the absence of those parameters was detected. 15 Two masked investigators (SJ, JB) interpreted the OCT images. When there was disagreement, the third investigator was consulted for the final decision (WKL).…”

Section: Patients and Clinical Data Acquisitionmentioning

confidence: 99%

Gli1 Expression in Human Epiretinal Membranes

Baek

Lee

2017

Invest. Ophthalmol. Vis. Sci.

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Citation: Jeon S, Baek J, Lee WK. Gli1 expression in human epiretinal membranes. Invest Ophthalmol Vis Sci. 2017;58:651-659. DOI:10.1167/ iovs.16-20409 PURPOSE. We evaluate the expression of Gli1 in human epiretinal membranes (ERM) and correlate this with clinical data. METHODS.We prospectively recruited patients with ERM. A total of 33 human ERM specimens were immunolabeled with anti-Gli1 antibody and the number of total cells/hyperfield (HF), Gli1(þ) cells/HF, and the percentage of Gli1(þ) cells/total cells were calculated. We evaluated the interrelationship of cellular properties and clinical findings, such as presence of diabetic retinopathy (DR), retinal breaks, intraocular inflammation, central foveal thickness, maximal retinal thickness, retinal contraction, lamellar holes, pseudoholes, the attenuation or absence of an inner segment/outer segment (IS/OS) junction/external limiting membrane (ELM), cystic changes, and paravascular inner retinal defects.RESULTS. Among 33 specimens, 25 specimens (75.8%) showed nuclear Gli1 expression. The mean Gli1(þ) cells/total cells was 54.0 6 36.7% (range, 0%-92.8%). There was significantly higher expression of Gli1(þ) cells in ERM specimens from patients with DR (P ¼ 0.014), and lower expression from patients with retinal breaks (P ¼ 0.022). Epiretinal membrane specimens from patients with alteration of IS/OS junction/ELM or cystic changes on OCT showed higher percentage of Gli1(þ) cells/total cells. CONCLUSIONS.Gli1 expression was detected in most ERM specimens. Patients who had DR or OCT findings indicating chronic retinal insults showed higher Gli1 expression. Gli1 may have a role in the pathogenesis of ERM after chronic retinal insults.

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“…[35][36][37][38] These are all included in one category as distinguishing between them was inconsistent between observers. We differentiated subretinal fluid from more subtle outer retinal changes and also from outer retinal dehiscence seen in impending macular holes.…”

Section: Figure 1 Schematic Representation Of the Focal Vmt Classificmentioning

confidence: 99%

The design and validation of an optical coherence tomography-based classification system for focal vitreomacular traction

Steel

Downey

Greiner

et al. 2016

Eye

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Correlation Between Foveal Cone Outer Segment Tips Line and Visual Recovery After Epiretinal Membrane Surgery

Abstract: The recovery of the foveal COST line defect is correlated with the BCVA after ERM surgery. The length of the preoperative COST line defect can predict the potential foveal function. (ClinicalTrials.gov number, NCT01549249.).

Cited by 102 publications

References 34 publications

Comparison of photoreceptor outer segment length in diabetic and idiopathic epiretinal membranes

Comparison of photoreceptor outer segment length in diabetic and idiopathic epiretinal membranes

Gli1 Expression in Human Epiretinal Membranes

The design and validation of an optical coherence tomography-based classification system for focal vitreomacular traction

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