Correlation between Flicker-Induced Retinal Vessel Vasodilatation and Plasma Biomarkers of Endothelial Dysfunction in Hypertensive Patients

Machalińska, Anna; Pius-Sadowska, Ewa; Babiak, Katarzyna; Sałacka, Anna; Safranow, Krzysztof; Piotr, Kawa Miłosz; Machaliński, Bogusław

doi:10.1080/02713683.2017.1358372

Cited by 21 publications

(5 citation statements)

References 42 publications

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“…Sörensen et al (2016) demonstrated reduced FID in patients with prediabetes compared to healthy individuals with further impairments in patients with manifest type 2 diabetes (Sörensen et al, 2016). Impaired FID has also been associated with hypertension (Machalinska et al, 2018), hypercholesterolemia (Nagele et al, 2018a), obesity (Kotliar et al, 2011) and higher age (Kneser et al, 2009). With respect to static retinal vessel diameters, narrower arterioles, wider venules and a resulting lower arterio-venous ratio (AVR) have been associated with incidence hypertension (Wang et al, 2003; Wong et al, 2004; Ikram et al, 2006b), stroke (Ikram et al, 2006a; McGeechan et al, 2009) and a higher CV morbidity and mortality (Wang et al, 2007; Seidelmann et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Retinal Endothelial Function, Physical Fitness and Cardiovascular Risk: A Diagnostic Challenge

et al. 2019

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Introduction Dynamic retinal vessel analysis (DVA) is a new non-invasive method to quantify microvascular endothelial dysfunction by flicker light-induced dilatation (FID). FID has been shown to be impaired in type 2 diabetes as well as heart failure. The aim of the study was to analyze FID in healthy active versus healthy sedentary and cardiovascular (CV) risk patients in addition to corresponding static vessel diameters. Methods Thirty-one healthy active (HA, mean age 60 ± 8 years), 33 healthy sedentary individuals (HS, 59 ± 7 years) and 76 sedentary patients with increased CV risk (SR, 58 ± 6 years) were included in this cross-sectional study. Group differences in CV risk factors and cardiorespiratory fitness, maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the arteriolar (AFarea) and venular (VFarea) area under the flicker curve were analyzed. The central retinal arteriolar and venular diameters were used to calculate the arteriolar-to-venular diameter ratio (AVR). Results HS [ADmax = 3.5 (2.1)%; AFarea = 48.2 (31.9)% ∗ s] showed higher FID compared to SR [ADmax = 2.7 (1.8)%, p = 0.021; AFarea = 34.5 (26.5)% ∗ s, p = 0.006] and HA [AFarea = 32.8 (23.1)% ∗ s, p = 0.029]. HA and SR did not significantly differ. HA had a higher AVR (0.87 ± 0.05) compared to HS (0.83 ± 0.04, p < 0.001) with further deterioration in SR (0.79 ± 0.05, p < 0.001). Interestingly, 28 participants had impaired FID but normal AVR and 43 participants had normal FID but impaired AVR. Discussion FID can differentiate between sedentary low and high risk individuals. However, FID in healthy active persons (HA) seemed impaired with a concomitant higher AVR. We postulate that lower FID in HA may be explained by predilatated arterioles and a reduced dilatation reserve. We recommend combination of FID with analysis of retinal vessel diameters to differentiate functional non-responders from manifest microvascular endothelial dysfunction and, thereby, improve microvascular risk stratification in a personalized medicine approach. Clinical Trial Registration ClinicalTrials.gov : NCT02796976 ( https://clinicaltrials.gov/ ct2/show/NCT02796976 ).

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Section: Introductionmentioning

confidence: 99%

Retinal Endothelial Function, Physical Fitness and Cardiovascular Risk: A Diagnostic Challenge

et al. 2019

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“…In the current study, there was no link between SDD and retinal vessel diameters or reactivity. These parameters indirectly indicate the function of the vascular endothelium, and their disturbance in arterial hypertension, atherosclerosis, and CAD has been previously demonstrated [98][99][100][101]. Interestingly, Rabiolo et al observed a reduced dilation response of the retinal arteries in eyes with SDD [22].…”

Section: Discussionmentioning

confidence: 89%

Association between Subretinal Drusenoid Deposits and Age-Related Macular Degeneration in Multimodal Retinal Imaging

Krytkowska,

Olejnik-Wojciechowska,

Grabowicz

et al. 2023

JCM

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Multimodal retinal imaging enables the detection of subretinal drusenoid deposits (SDD) with significantly greater accuracy compared to fundus photography. The study aimed to analyze a relationship between the presence of SDD, the clinical picture of AMD, and disease progression in a 3 year follow-up. A total of 602 eyes of 339 patients with a diagnosis of AMD, of which 121 (55%) had SDD confirmed in multimodal retinal imaging, were enrolled in the study. SDD was related to a more advanced stage of AMD (p = 0.008), especially with the presence of geographic atrophy (OR = 4.11, 95% CI 2.02–8.38, p < 0.001). Eyes with SDD presented significantly lower choroidal and retinal thickness (ATC: 210.5 μm, CRT: 277 μm, respectively) and volume (AVC: 0.17 mm3, CRV: 8.29 mm3, p < 0.001, respectively) compared to SDD-negative eyes (ATC: 203 μm, CRT: 277 μm; AVC: 7.08 mm3, 8.54 mm3, p < 0.001). Accordingly, the prevalence of pachychoroids and pachyvessels was significantly lower in the SDD present group than in eyes without SDD (p = 0.004; p = 0.04, respectively). Neither demographic factors, lipid profile, genetic predisposition, systemic vascular disease comorbidities, nor parameters of retinal vessels were affected by the presence of SDD. We found no effect of SDD presence on AMD progression (p = 0.12). The presence of SDD appeared to be related to local rather than systemic factors.

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“…Similarly, to exclude factors that could distort the test results, patients were advised to refrain from drinking coffee or smoking cigarettes for at least 5 h before the examination. During the static vessel analysis (SVA), 30-degree retinal photographs of each subject were taken with the FF450 plus fundus camera (Zeiss AG, Jena, Germany), as previously described [14,28]. The images were further analysed using VISUALIS and VesselMap software (IMEDOS Systems, Ltd., Jena, Germany).…”

Section: Retinal Vessel Analysismentioning

confidence: 99%

Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration?

et al. 2023

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The aims of this study were to analyze the relationship between the presence of the cilioretinal artery (CRA) and the incidence, severity and progression of age-related macular degeneration (AMD) and to estimate the influence of the CRA on choroidal and retinal parameters. A total of 287 patients with AMD and 110 healthy controls were enrolled in the study. CRA occurrence was determined using color fundus images. AMD progression was assessed after 3 years. There was no difference in the incidence of CRA between the AMD and control groups (23.34% vs. 24.55%; p = 0.8). Lower-stage AMD was more frequently observed in eyes with the CRA than in eyes without the artery (p = 0.016). The CRA did not influence disease progression (p = 0.79). The CRA did not influence retinal and choroidal thickness and volume parameters or the retinal vessel caliber and functionality in either the AMD or control groups. There was no relationship between CRA presence and CFH Y402H and ARMS2 A69S risk variants. The results did not show a protective effect of the CRA on the incidence and progression of AMD. The CRA may affect the severity of AMD; however, the mechanism of this phenomenon is unclear.

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Correlation between Flicker-Induced Retinal Vessel Vasodilatation and Plasma Biomarkers of Endothelial Dysfunction in Hypertensive Patients

Abstract: Our results indicate that DVA directly reflects the actual metabolic status of the retinal endothelium. DVA might be used as an early noninvasive screening tool to detect vascular dysregulation and pan-endothelial dysfunction in patients with HT.

Cited by 21 publications

References 42 publications

Retinal Endothelial Function, Physical Fitness and Cardiovascular Risk: A Diagnostic Challenge

Retinal Endothelial Function, Physical Fitness and Cardiovascular Risk: A Diagnostic Challenge

Association between Subretinal Drusenoid Deposits and Age-Related Macular Degeneration in Multimodal Retinal Imaging

Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration?

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