Correlation between first trimester uric acid level and subsequent development of gestational diabetes mellitus

Amudha, P; Nithya, D; Soundararajan, Pradeeba; Manochithra, B

doi:10.18203/2320-1770.ijrcog20170391

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Elevated serum uric acid can predict the development of diabetes and hence can be considered as an early sign of peripheral insulin resistance syndrome. Elevated or high normal levels of serum uric acid in first trimester may be associated with a preexisting metabolic derangements which lead to poor maternal physiological adaptations and predisposes the pregnant women to development of pregnancy complication like GDM (14).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of uric acid levels as antioxidant during normal pregnancy and pregnancy with complication (diabetes and hypertension)

et al. 2018

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The uric acid is a waste product of the living cell, produced by xanthine oxidase, which contributes up to 60% of the total plasma antioxidant activity in healthy subjects. The study provides data relating serum uric acid, glucose levels and blood hypertension. Seventy nine patients with pregnancy diabetes mellitus, 25 normal healthy with pregnancy, 25 DM patients, and fifty normal healthy persons, where seen from February till July 2017, in Al-Semawa General Hospital, were participated in the study. The results revealed a highly significant difference (P<0.001) in uric acid, glucose level and hypertension in almost pregnancy diabetic patients and DM patients when compared to control group. In conclusion, this study found that pregnancy women at the early development stage of glucose disorders had a significantly of hyperuricemia and in clinical practices, measurement of serum uric acid level may help to identify the risk of hypertension.

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Section: Discussionmentioning

confidence: 99%

Evaluation of uric acid levels as antioxidant during normal pregnancy and pregnancy with complication (diabetes and hypertension)

et al. 2018

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The predictive role of serum uric acid levels before pregnancy in the development of gestational diabetes mellitus

Ghanei,

Mohammadzade,

Gholami Banadkoki

et al. 2023

Diabetol Int

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Maternal uric acid levels and risk of gestational diabetes mellitus: A systematic review and dose–response meta‐analysis of cohort studies including 105,380 participants

Nikparast

Rahmani

Bagheri

et al. 2023

J of Diabetes Invest

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Aims/Introduction Although the association between uric acid levels and adverse pregnancy outcomes has been investigated, the effects of higher uric acid levels on the risk of gestational diabetes mellitus (GDM) have yet to be established. Therefore, this systematic review and meta‐analysis aimed to investigate the relationship between uric acid levels during pregnancy and the risk of GDM. Materials and Methods PubMed/Medline, Scopus and Web of Science databases were searched up to April 2022 for relevant observational studies. A random effects model was used to estimate pooled odds ratios (OR) and 95% confidence intervals (95% CI). To assess the heterogeneity of included studies, the I2 index was used. Results Among the initial 262 studies that were recognized from the databases search, 23 studies including 105,380 participants were eligible. Pooled analysis showed that higher uric acid levels significantly affected the risk of GDM (OR 2.58, 95% CI 1.89–3.52, I2 = 90.8%, P < 0.001). Subgroup analyses based on the gestational week showed that higher uric acid levels before the 20th week of gestation were significantly associated with the risk of GDM (OR 3.26, 95% CI 2.26–4.71, I2 = 89.3%, P < 0.001). Based on the meta‐regression analysis, uric acid levels and odds of GDM were significantly correlated with the participants' age, and it was more significant in younger pregnant women. Conclusions This study showed a positive association between uric acid levels and the risk of GDM. Also, our results indicate that measuring uric acid levels before 20 weeks of gestation can potentially predict GDM, especially in younger women.

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Correlation between first trimester uric acid level and subsequent development of gestational diabetes mellitus

Cited by 4 publications

References 10 publications

Evaluation of uric acid levels as antioxidant during normal pregnancy and pregnancy with complication (diabetes and hypertension)

Evaluation of uric acid levels as antioxidant during normal pregnancy and pregnancy with complication (diabetes and hypertension)

The predictive role of serum uric acid levels before pregnancy in the development of gestational diabetes mellitus

Maternal uric acid levels and risk of gestational diabetes mellitus: A systematic review and dose–response meta‐analysis of cohort studies including 105,380 participants

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