Correlation between fetal autopsy and prenatal diagnosis by ultrasound: A systematic review

Rossi, A. Cristina; Prefumo, Federico

doi:10.1016/j.ejogrb.2016.12.024

Cited by 65 publications

(66 citation statements)

References 24 publications

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“…Compared with other published studies, our US confirmation rate with autopsy at 42/81 (51.8%) cases is slightly lower than the 68% agreement rate reported by Rossi et al in their systematic review of over 3500 prenatal US examinations. Nevertheless, our additional yield of new information from autopsy at 23.5% is similar to their 22.5% autopsy yield rate.…”

Section: Discussioncontrasting

confidence: 84%

Is traditional perinatal autopsy needed after detailed fetal ultrasound and post‐mortem MRI?

et al. 2019

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Objective To determine the additional yield from autopsy following prenatal ultrasound and post‐mortem magnetic resonance imaging (PMMR) for structural abnormalities. Method PMMR was performed on consecutive fetuses over a 6‐year period. Prenatal ultrasound and PMMR findings were categorised as concordant, partially concordant or discordant findings. The yield of new and clinically significant information from autopsy was assessed. Diagnostic accuracies for both modalities were calculated, using autopsy as reference standard. Results Our study consisted of 81 fetuses. PMMR and prenatal ultrasound findings were concordant in 44/81 (54.3%), partially concordant in 26/81 (32.1%) and discordant in 11/81 (13.6%) cases. In 19/81 cases (23%), autopsy provided additional information, which appeared clinically significant in 12 cases. In 10 of those 12 cases, there was discordance between PMMR and ultrasound. In only 2 of 44 cases where ultrasound and PMMR were concordant, did autopsy provide clinically significant information. Diagnostic accuracy rates for ultrasound were sensitivity of 76.8% (66.6%, 84.6%), specificity of 92.5% (88.9%, 95.0%). For PMMR the sensitivity was 79.0% (68.9%, 86.5%), specificity 97.9% (95.5%, 99.0%). PMMR had a significantly higher concordance rate with autopsy than ultrasound (89.0 vs 93.8%; P < .001). Conclusion Where PMMR and ultrasound are concordant, there is little additional yield from autopsy.

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Section: Discussioncontrasting

confidence: 84%

Is traditional perinatal autopsy needed after detailed fetal ultrasound and post‐mortem MRI?

et al. 2019

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“…Rossi AC et al in their study showed 3.2% false positive and 2.8% false negative cases. [16] In this study, false negativity was 40% which is much higher.…”

Section: Discussionmentioning

confidence: 96%

Comparison Between Prenatal and Perinatal Imaging and Foetal Autopsy Results in a Tertiary Care Hospital in South India

Shali¹,

Feroze²

2017

jemds

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BACKGROUNDEvaluation of a congenital anomaly starts from antenatal period by the assessment of the maternal and family risk factors and ultrasonogram evaluation. Postnatal evaluation includes morphologic, radiologic, histopathological and karyotypic studies with investigations for infectious, genetic and metabolic causes. Although, some anomalies can be detected by ultrasonogram and xrays, a foetal autopsy has to be done to confirm the diagnosis and look for associated anomalies. Objectives-To assess the efficacy of foetal autopsy over prenatal ultrasound and post-mortem x-ray examination.

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“…We did not have information on women who had abortions, including the presence of nervous system defects in aborted fetuses. Although, it is unlikely that abortion rates differ between women with and without asthma, central nervous system defects are a common reason for pregnancy terminations (Rossi & Prefumo, ). Thus, pregnancy terminations may have reduced the study power, and statistical significance of associations between asthma and nervous system defects.…”

Section: Discussionmentioning

confidence: 99%

Prepregnancy asthma and the subsequent risk of central nervous system defects in offspring

Auger

Arbour

Kabageni

et al. 2019

Birth Defects Research

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Background: The relationship between childhood asthma and central nervous system defects in offspring is poorly understood. We assessed if childhood asthma was associated with the risk of having an infant with neural tube or other nervous system defects compared with asthma during pregnancy. Methods: We analyzed a longitudinal cohort of 128,060 women who were 5 years or less at study entry and later delivered an infant in Quebec, Canada (1989Canada ( -2014. We identified women hospitalized for asthma before pregnancy, including childhood and adolescence, and determined if asthma was present during pregnancy based on obstetric records. Main outcomes were neural tube and non-neural tube defects in pregnancy. We used log-binomial regression models to determine risk ratios (RR) and 95% confidence intervals (CI) for the association between asthma and risk of nervous system defects, adjusting for patient characteristics. Results: Asthma was associated with a greater risk of neural tube defects in offspring (RR 2.39, 95% CI 1.03-5.53) compared with no asthma, but not non-neural tube defects (RR 1.10, 95% CI 0.71-1.71). Women whose asthma resolved before pregnancy had a greater risk of neural tube defects (RR 3.43, 95% CI 1.35-8.69), while women with asthma during pregnancy were at greater risk of non-neural tube defects, especially microcephaly (RR 2.80, 95% CI 1.23-6.40). Conclusions: Asthma that resolved before pregnancy was associated with an increased risk of neural tube defects in offspring but not non-neural tube defects. Further investigation is needed to determine the pathophysiology connecting childhood asthma with nervous system defects in offspring.

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Correlation between fetal autopsy and prenatal diagnosis by ultrasound: A systematic review

Cited by 65 publications

References 24 publications

Is traditional perinatal autopsy needed after detailed fetal ultrasound and post‐mortem MRI?

Is traditional perinatal autopsy needed after detailed fetal ultrasound and post‐mortem MRI?

Comparison Between Prenatal and Perinatal Imaging and Foetal Autopsy Results in a Tertiary Care Hospital in South India

Prepregnancy asthma and the subsequent risk of central nervous system defects in offspring

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