Correlation between expression of leptin and clinicopathological features and prognosis in patients with gastric cancer

Zhao, Xiaolong; Huang, Kaihong; Zhu, Zhengyan; Chen, Shuhong; Hu, Renming

doi:10.1111/j.1440-1746.2007.04941.x

Cited by 54 publications

(46 citation statements)

References 30 publications

(36 reference statements)

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“…Poorly cohesive carcinomas belong to the diffuse type according to the Lauren classification. By analyzing 61 gastric cancer cases, Zhao et al observed a significant association between leptin expression and vascular endothelial growth factor (VEGF) expression [105]. Further, leptin expression in these gastric cancer tissues was significantly associated with histology, Borrmann classification, lymph node metastasis and stage.…”

Section: Leptin and Tumor Behavior Of The Gastrointestinal Tractmentioning

confidence: 99%

The potential role of leptin in tumor invasion and metastasis

Ray

Cleary

2017

Cytokine & Growth Factor Reviews

110

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The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in obesity compared to its functions in the normal healthy state. In obese individuals, elevated leptin levels act as a pro-inflammatory adipokine and are associated with certain types of cancers. Further, a growing body of evidence suggests that higher circulating leptin concentrations and/or elevated expression of leptin receptors (Ob-R) in tumors may be poor prognostic factors. Although the underlying pathological mechanisms of leptin’s association with poor prognosis are not clear, leptin can impact the tumor microenvironment in several ways. For example, leptin is associated with a number of biological components that could lead to tumor cell invasion and distant metastasis. This includes interactions with carcinoma-associated fibroblasts, tumor promoting effects of infiltrating macrophages, activation of matrix metalloproteinases, transforming growth factor-β signaling, etc. Recent studies also have shown that leptin plays a role in the epithelial-mesenchymal transition, an important phenomenon for cancer cell migration and/or metastasis. Furthermore, leptin’s potentiating effects on insulin-like growth factor-I, epidermal growth factor receptor and HER2/neu have been reported. Regarding unfavorable prognosis, leptin has been shown to influence both adenocarcinomas and squamous cell carcinomas. Features of poor prognosis such as tumor invasion, lymph node involvement and distant metastasis have been recorded in several cancer types with higher levels of leptin and/or Ob-R. This review will describe the current scenario in a precise manner. In general, obesity indicates poor prognosis in cancer patients.

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Section: Leptin and Tumor Behavior Of The Gastrointestinal Tractmentioning

confidence: 99%

The potential role of leptin in tumor invasion and metastasis

Ray

Cleary

2017

Cytokine & Growth Factor Reviews

110

View full text Add to dashboard Cite

show abstract

“…In patients with OGC, a number of primary and secondary causes of reduced dietary intake are at work simultaneously, including dysphagia (McKernan et al, 2008), early satiety (Davis et al, 2006), chronic nausea (McKernan et al, 2008), alterations in circulating neuroendocrine hormones (e.g., ghrelin (Isomoto et al, 2005) and leptin (Huang et al, 2005;Zhao et al, 2007)), hypogeusia/hyposmia (Plata-Salaman, 2000), and cytokine-induced central anorexia (Plata-Salaman, 2001;Turrin et al, 2004). Assuming that MIC-1 may be a modulator of appetite in humans, the complex constellation of additional factors also controlling food intake may explain why plasma MIC-1 concentrations did not correlate with nutritional status in this study.…”

Section: Crp (Mg Lmentioning

confidence: 99%

Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer

et al. 2010

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BACKGROUND: Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC). METHODS: Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of X10 mg l -1 or modified Glasgow prognostic score (mGPS) of X1), and nutritional status were assessed in newly diagnosed OGC patients (n ¼ 293). Healthy volunteers (n ¼ 35) served as controls. RESULTS: MIC-1 was elevated in patients (median ¼ 1371 pg ml -1 ; range 141 -39 053) when compared with controls (median ¼ 377 pg ml -1 ; range 141 -3786; Po0.001). Patients with gastric tumours (median ¼ 1592 pg ml -1 ; range 141 -12 643) showed higher MIC-1 concentrations than patients with junctional (median ¼ 1337 pg ml -1 ; range 383 -39 053) and oesophageal tumours (median ¼ 1180 pg ml -1 ; range 258 -31 184; P ¼ 0.015). Patients showed a median weight loss of 6.4% (range 0.0 -33.4%), and 42% of patients had an mGPS of X1 or plasma CRP of X10 mg l -1 (median ¼ 9 mg l -1 ; range 1 -200). MIC-1 correlated positively with disease stage (r 2 ¼ 0.217; Po0.001), age (r 2 ¼ 0.332; Po0.001), CRP (r 2 ¼ 0.314; Po0.001), and mGPS (r 2 ¼ 0.336; Po0.001), and negatively with Karnofsky Performance Score (r 2 ¼ À0.269; Po0.001). However, although MIC-1 correlated weakly with dietary intake (r 2 ¼ 0.157; P ¼ 0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median ¼ 204 days; 95% CI 157 -251) when compared with patients with MIC-1 levels in the lower three quartiles (median ¼ 316 days; 95% CI 259 -373; P ¼ 0.036), but MIC-1 was not an independent prognostic indicator. CONCLUSIONS: There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.

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“…We thought that the main reason for these results were different histopathological subgroups and chemotherapy regimens. Not only lung carcinoma, but also leptin shows a prognostic value for the overall survival rate in patients with gastric adenocarcinoma (17), hepatocellular carcinoma (18) and colorectal adenocarcinoma (19). Although Duru (20) et al found high serum leptin levels in advanced stage of lung NSCLC compared to healthy subjects, we did not fi nd any correlation between serum leptin levels and lung cancer stage or histological subtype.…”

Section: Discussionmentioning

confidence: 99%

Are serum leptin levels a prognostic factor in advanced lung cancer?

Anar¹,

Deniz²,

Erol³

et al. 2017

BLL

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AIM: The aim of the present study was to evaluate pre-treatment concentrations of leptin in patients with advanced lung cancer and to investigate possible associations between their levels and clinicopathological variables, response to therapy and overall survival. MATERIAL AND METHODS: There are 71 previously untreated patients with cytological or histological evidence of primary lung cancer who were admitted to the oncology department between November 2013 and August 2014. Forty-fi ve healthy individuals with age, sex and BMI matching the lung cancer patients, were recruited to take part in the study as a control group. Leptin levels were measured quantitatively by using a microELISA kit. RESULTS: The serum leptin levels at diagnosis were signifi cantly lower in lung cancer patients than those in control subjects (4.75 ± 4.91 ng/ml, 9.67 ± 8.02 ng/ml; p < 0.001). We did not fi nd any signifi cant difference in leptin values related to clinicopathological parameters such as ECOG PS, weight loss, histological type, disease stage and TNM classifi cation. Nevertheless, we demonstrated a signifi cant correlation between serum leptin levels and BMI in lung cancer patients (correlation coeffi cient: 0.303; p > 0.010). The analysis of serum leptin values did not show any association with the overall survival of the patients. CONCLUSION: Our results showed that the serum leptin level has no prognostic indications in advanced lung cancer patients. Leptin is decreased in lung cancer, and there is lack of correlation with tumour-related factors including prognosis. Therefore, leptin is not a useful clinical marker in lung cancer (Tab. 2, Fig. 2, Ref. 22). Text in PDF www.elis.sk.

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Correlation between expression of leptin and clinicopathological features and prognosis in patients with gastric cancer

Cited by 54 publications

References 30 publications

The potential role of leptin in tumor invasion and metastasis

The potential role of leptin in tumor invasion and metastasis

Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer

Are serum leptin levels a prognostic factor in advanced lung cancer?

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