Correlation between Erythropoietin and Lactate in Humans during Altitude Exposure.

Satoh, Susumu; Shimizu, Satoshi; Kishi, Takashi; Hirai, Katsuyuki; Mori, Ippei; Ohno, Yoshimi; Ueda, Masatsugu; Takaki, Miyako; Kohzuki, Hisaharu; Okamoto, Shingo; Shimamoto, Ikuko; Yanagi, Susumu; Ogoshi, Kumiko; Sherchand, Jeevan Bahadur

doi:10.2170/jjphysiol.50.285

Cited by 11 publications

(11 citation statements)

References 15 publications

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“…With isobaric hypoxia of about 17.0-14.8% O 2 (+/-0.2) in rooms equipped with hypoxia systems for fire prevention, exposure of employees is equivalent to an altitude of about 1,700-2,600 m. This altitude is well within the range of the so-called "threshold altitude", which is the altitude, where the body shows the first responses to hypoxia. Depending on the system observed, the threshold altitude varies between 1,500 m (slight increase in pulse rate at rest) to 2,400 m (increase of erythropoietin serum concentration) [28,29]. In conclusion altitudes around the threshold do not cause any risk for healthy people by hypoxia.…”

Section: Types Of Occupational Exposure To Hypoxic Conditionsmentioning

confidence: 89%

Occupational Aspects of Work in Hypoxic Conditions - The New Recommendation of the Medical Commission of the Union Internationale des Associations d'Alpinisme (UIAA MedCom)

Küpper¹,

Milledge²,

Hillebrandt³

et al. 2010

Medicina Sportiva

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More and more persons are exposed to hypoxia while working at altitude, e.g. when working for cable cars or ski areas in the Alps, for business in South America or Asia, as airline crews, or in rooms with reduced oxygen pressure for hypoxia training or fire protection. Unfortunately, the different countries have a multitude of regulations for occupational health and safety concerning hypoxia -most of them with major deficiencies and a significant lack of knowledge about hypoxia and possible specific risks. So far, no national regulation differentiates the different types of hypoxia and the environment, both having significant influence on the specific risk profile of employees and consequences for occupational health and safety.As the world's umbrella body for preventive medicine at altitude / hypoxia, the Medical Commission of the Union Internationale des Associations d'Alpinisme (UIAA MedCom) recently established a recommendation to enable the national bodies to establish knowledge-based pragmatic procedures for occupational health and safety [1]. The most important message is as follows: Any environment with oxygen concentration of 14.0% or more or an altitude of 3,000 m or less is safe for any non-acclimatized person without severe cardiopulmonary disease (10 g/dl) and an exposure limited to a few hours (one work shift). These environments include most alpine cable cars, ski areas, aircrafts flying on long-range distances, most towns or villages where businessmen might go to, and rooms for fire protection. For longer exposure (sleep at high altitude) or higher environments the persons should be acclimatized or exposed for a short time only. Details how to manage health and safety in such environments are given.

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Section: Types Of Occupational Exposure To Hypoxic Conditionsmentioning

confidence: 89%

Occupational Aspects of Work in Hypoxic Conditions - The New Recommendation of the Medical Commission of the Union Internationale des Associations d'Alpinisme (UIAA MedCom)

Küpper¹,

Milledge²,

Hillebrandt³

et al. 2010

Medicina Sportiva

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“…This is well within the range of the so-called 'threshold altitude', which is the (corresponding) altitude, where the body shows the first responses to hypoxia. Depending on the system observed, the threshold altitude varies between 1500 (slight increase in pulse rate at rest) to 2400 m (increase of erythropoietin serum concentration) (Gunga et al, 1994;Sakata et al, 2000). In conclusion, altitudes around the threshold do not cause any risk for healthy people by hypoxia, but they cause a physiological response on the body.…”

Section: Extreme Short Exposurementioning

confidence: 92%

Work in Hypoxic Conditions-Consensus Statement of the Medical Commission of the Union Internationale des Associations d'Alpinisme (UIAA MedCom)

Küpper

Milledge

Hillebrandt³

et al. 2011

The Annals of Occupational Hygiene

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Objectives: The Commission gives recommendations on how to provide health and safety for employees in different kinds of low oxygen atmospheres. So far, no recommendations exist that take into account the several factors we have outlined in this report.Methods: The health and safety recommendations of several countries were analysed for their strength and deficiencies. The scientific literature was checked (Medline, etc.) and evaluated for relevance of the topic. Typical situations of work in hypoxia were defined and their specific risks described. Specific recommendations are provided for any of these situations.Results: We defined four main groups with some subgroups (main risk in brackets): short exposure (pressure change), limited exposure (acute altitude disease), expatriates (chronic altitude disease), and high-altitude populations (re-entry pulmonary oedema). For healthy unacclimatized persons, an acute but limited exposure down to 13% O 2 does not cause a health risk. Employees should be advised to leave hypoxic areas for any break, if possible. Detailed advice is given for any other situation and pre-existing diseases.Conclusions: If the specific risk of the respective type of hypoxia is taken into account, a pragmatic approach to provide health and safety for employees is possible. In contrast to other occupational exposures, a repeated exposure as often as possible is of benefit as it causes partial acclimatization. The consensus statement was approved by written consent in lieu of a meeting in July 2009.

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“…Durante uma ascensão de 3 dias até uma altitude de 4559 metros, os valores de EPO foram gradualmente aumentando ao longo da exposição, tendo-se encontrado o resultado mais elevado quando os alpinistas atingiram a referida altitude (48). Porém, se a secreção acrescida de eritropoietina se inicia imediatamente após a exposição aguda à altitude (1,42,68), a produção aumentada de glóbulos vermelhos é retardada, assumindo incrementos significativos apenas após algumas semanas de exposição crónica a altitudes superiores a 3000 metros e valores máximos alguns meses depois (47). De destacar que na fase de exposição crónica, em que a produção acrescida de eritrócitos se torna significativa, os níveis de eritropoietina já se encontram perto dos valores pré-altitude (47).…”

Section: Adaptações Hematológicasunclassified

O desafio da altitude. Uma perspectiva fisiológica

Magalhães¹,

Duarte²,

Ascensão³

et al. 2002

RPCD

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RESUMOA prática de actividades físicas em altitude tem sofrido um aumento significativo ao longo dos últimos anos. Estas actividades, de que são exemplo o montanhismo, o alpinismo e o esqui, implicam a exposição esporádica ou prolongada dos "turistas de altitude" a ambientes de hipóxia hipobárica e, em consequência, induzem elevada agressão orgânica. No presente trabalho serão descritas as adaptações fisiológicas agudas e cró-nicas que ocorrem (i) nos sistemas respiratório e circulatório, (ii) nos componentes hematológicos e (iii) na morfologia e metabolismo musculares, com o objectivo de atenuar os efeitos fisiológicos da rarefação do oxigénio no ar atmosférico, possibilitando a permanência e a funcionalidade do Homem nestes locais hostis. Na perspectiva do rendimento desportivo, serão abordados, de forma sumária, o efeito fisiológico e os benefí-cios para o desempenho ao nível do mar decorrentes do denominado "treino em altitude". Palavras-chave:Altitude, hipóxia, adaptações fisiológicas agudas, adaptações fisiológicas crónicas, treino em altitude. ABSTRACT

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Correlation between Erythropoietin and Lactate in Humans during Altitude Exposure.

Cited by 11 publications

References 15 publications

Occupational Aspects of Work in Hypoxic Conditions - The New Recommendation of the Medical Commission of the Union Internationale des Associations d'Alpinisme (UIAA MedCom)

Occupational Aspects of Work in Hypoxic Conditions - The New Recommendation of the Medical Commission of the Union Internationale des Associations d'Alpinisme (UIAA MedCom)

Work in Hypoxic Conditions-Consensus Statement of the Medical Commission of the Union Internationale des Associations d'Alpinisme (UIAA MedCom)

O desafio da altitude. Uma perspectiva fisiológica

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