Correlation between echocardiographic findings and biochemical markers in term newborns with moderate to severe perinatal asphyxia

Abstract

Perinatal asphyxia (PA) is a condition characterized by a gas exchange disorder due to a lack of blood flow or gas exchange, with potential multiorgan dysfunction. Our study aimed to determine the correlation between biochemical markers and echocardiography findings in a group of asphyxiated newborns. The prospective cohort study included 120 neonates (52/120 with PA) treated at a tertial referral pediatric center, from 2012 to 2014. A moderate-strong positive correlation was recorded between the transtricuspid pressure gradient (TRPG) and serum lactate, and between TRPG and NT-proBNP in the PA group (P<0.001) on the 1st day of life. A moderate positive correlation was found between NT-proBNP, lactate and troponins on one side, and TRPG on the other in the PA group after the 2nd measurement. Multinomial regression analysis showed that the lactate level was an independent factor for survival on the 1st (odds ratio (OR) 41.3, 95%confidence interval (CI) 2.14-797.1) and 3rd (OR 136.4, 95% CI 2.27-8206.7) days. Our research confirmed a significant correlation between echocardiographic and biochemical parameters of the myocardial lesion and cardiac function. Due to their complementarity, the use of the biochemical and echocardiographic parameters may be conditioned by their availability.

Selected cardiac biomarkers in newborns with perinatal asphyxia symptoms

“…Furthermore, the authors showed that the value of this marker was positively correlated with the severity of HIE (5) . Many researchers have observed a significant increase in NT-proBNP concentration in neonates with myocardial injury due to PA (10,11) . Researchers from other centres reported significantly increased levels of NT-proBNP, measured in both blood and urine samples, in preterm newborns with PDA (12,13) .…”