Correlation between dyslipidemia and severity of allergic rhinitis

Ahmed, Mohamed; Madian, Yasser T.; ElTabbakh, Mohammed T.; El‐Serafi, Ahmed T.; Nasr, Gamela; Hessam, Waheed F.

doi:10.4103/ejo.ejo_90_17

Cited by 3 publications

(4 citation statements)

References 23 publications

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“…30 We report a positive correlation between TC levels and both VAS score, and RQLQ score. Ahmed et al in a recent Egyptian study reported similar results, 29 which was also confirmed by regression analysis of Yon et al 31 TC and LDL-C were associated with the severity of AR high TC, which has been reported to increase allergen-specific IgE synthesis thus exacerbating allergic symptoms, which denotes a positive correlation between dyslipidemia and atopy. 32 This could be attributed to the impact of dyslipidemia on the immune system where dyslipidemia induces a shift toward an immunologic Th2-oriented response and exacerbates allergic inflammation.…”

Section: Discussionsupporting

confidence: 58%

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Lipid Profile and IL-17A in Allergic Rhinitis: Correlation With Disease Severity and Quality of Life

Sheha

El‐Korashi

AbdAllah

et al. 2021

JAA

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Background Recent data display the possible role of cytokines such as interleukin-10 (IL-10), IL-17 and IL-23 as a link between dyslipidemia and atopy; however, the relationship between dyslipidemia, allergic rhinitis (AR), and the underlying mechanisms involved is unclear. Purpose To measure the lipid profile and IL-17A level in AR patients in comparison to healthy controls, and correlate serum lipid level with the severity of symptoms and quality of life (QoL) of AR patients. Patients and Methods Peripheral blood samples were collected from AR patients (n=70) and a control group (n=80). Samples were analyzed for serum total IgE by ELISA, serum lipid profile, and IL-17A level by ELISA. Severity of AR symptoms was assessed by visual analogue scale (VAS) score and the rhinoconjunctivitis QoL questionnaire. Results Serum lipid profile and level of IL-17A in AR patients were significantly higher in comparison to controls (P < 0.001). Positive correlations were found between total cholesterol (TC) and the severity of AR and QoL. IL-17A was positively correlated with triglyceride (TG) level and low-density lipoprotein cholesterol (LDL-C) (P=0.011, r =0.303; P=0.043, r =0.242, respectively). Additionally, IL-17A was negatively correlated with high-density lipoprotein cholesterol (HDL-C) level ( P =0.036, r =−0.251). IL-17A was positively correlated with both age and VAS score with statistical significance (P=0.033, r =0.225; P=0.011, r =0.302, respectively). Conclusion Dyslipidemia might play a potential role in the severity of AR symptoms and impairment of patients’ QoL. Highlighting this association might alert physicians to evaluate the lipid profile in AR patients for timely diagnosis and treatment of dyslipidemia in an attempt to improve disease control and improve QoL.

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Section: Discussionsupporting

confidence: 58%

“… 28 Recent publications suggest the role of dyslipidemia in promoting atopic inflammation, through polarizing Th2 response. 7 , 29 Another proposed theory is the cholesterol trafficking. Cholesterol is a critical microdomain of cell wall lipid rafts that plays an essential role in cell signaling.…”

Section: Discussionmentioning

confidence: 99%

Lipid Profile and IL-17A in Allergic Rhinitis: Correlation With Disease Severity and Quality of Life

Sheha

El‐Korashi

AbdAllah

et al. 2021

JAA

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“…This is partially in line with previous studies. 5 , 16 , 17 Dyslipidemia promotes Th2 and Th17 cytokine profile release (IL-6, IL-1, IL-4, and IL17) 12 and also downregulates IL-10. 18 All these factors promote and exacerbate a state of chronic inflammation which in turn exacerbates AR symptoms.…”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia among allergic rhinitis patients: Frequency and risk factors

Sheha

El‐Korashi

AbdAllah

et al. 2021

World Allergy Organization Journal

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Background Although cumulative data strongly suggest an association between dyslipidemia and allergic disorders, especially asthma, evidence regarding allergic rhinitis (AR) is lacking. We aimed to assess frequency and associated risk factors of dyslipidemia among patients with AR. Methods The current study is a cross-sectional study that recruited 150 AR patients by systematic randomization. Blood samples for serum lipid profile, total immunoglobulin E (IgE) and serum interleukin-17A (IL-17A) were withdrawn from all patients. Results Dyslipidemia was prevalent in 84 AR patients (56%). Higher levels of total IgE, IL17-A, and sensitization to hay dust and mixed mites significantly increased the risk of dyslipidemia among AR patients by 1.004, 1.062, 4.057 and 3.652 respectively ( P < 0.05). Conclusion High serum total IgE level, high serum IL-17A level, and sensitization to hay dust and mixed mites are independent risk factors for dyslipidemia among AR patients.

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“…Total cholesterol (TC) and LDL levels correlate with the severity of AR in the paediatric population [ 15 ], and adults with AR and dyslipidaemia have poorer quality of life than those without dyslipidaemia [ 16 ]. Higher HDL values indicate a reduced likelihood of developing AR in children with a family history of allergies.…”

Section: Introductionmentioning

confidence: 99%

The relationship between lipid parameters and the course of allergic rhinitis in children

Kowalczyk,

Krogulska

2023

pdia

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Introduction A possible mechanism in the pathogenesis of allergic rhinitis (AR) is hypercholesterolemia, which may shift the balance between Th1- and Th2-dependent immune responses towards the latter. Aim To assess the prevalence of lipid metabolism abnormalities in children with AR and their influence on the clinical course of AR. Material and methods The study sample comprised 80 children (7–17 y.o.) with AR, including 28 with associated asthma, and 40 healthy children. Total blood cholesterol, HDL, LDL and triglyceride levels were evaluated (ARCHITECTcSystem). Skin prick tests (Allergopharma) for airborne allergens and a methacholine challenge test (Lungtest 1000, Ispa) were performed. Allergen-specific IgE for airborne allergens (Biocheck GmbH), FeNO and nNO concentrations (HypAir FeNO Medisoft) were measured. Results Children with AR were significantly more likely to have normal HDL levels than the control group ( n = 70; 87.5% vs. n = 27; 67.50%; p = 0.03). No significant differences were observed between these two groups regarding total cholesterol, LDL or triglyceride levels ( p > 0.05). Abnormally high total cholesterol levels were associated with a higher risk of sensitisation to D. pteronyssinus ( n = 18; 72%, p = 0.023). Children with normal levels of total cholesterol and normal triglyceride values were less likely to be sensitized to dog dander ( n = 43; 78.18%, p = 0.049) ( n = 42; 72.41%, p = 0.042). No significant correlations were observed between lipid parameters and the clinical course of AR, FeNO concentrations, nNO concentrations and bronchial hyperreactivity in children with AR ( p > 0.05). Conclusions Children with AR are as likely to demonstrate dyslipidaemia as the general population. However, the presence of lipid abnormalities in this group may increase the likelihood of sensitization to perennial allergens.

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Correlation between dyslipidemia and severity of allergic rhinitis

Cited by 3 publications

References 23 publications

Lipid Profile and IL-17A in Allergic Rhinitis: Correlation With Disease Severity and Quality of Life

Lipid Profile and IL-17A in Allergic Rhinitis: Correlation With Disease Severity and Quality of Life

Dyslipidemia among allergic rhinitis patients: Frequency and risk factors

The relationship between lipid parameters and the course of allergic rhinitis in children

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