Correlation between DQB1 genetic polymorphism and genetic susceptibility in patients diagnosed with irritable bowel syndrome with diarrhea

Yu, Fenglian; Huang, Shujie; Zhou, Fang; Luo, Qing; Xie, Xiaoli; Zheng, Chengbin

doi:10.4238/2014.december.4.23

Cited by 3 publications

(1 citation statement)

References 19 publications

(18 reference statements)

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“…However, our study has the strength of a higher precision of genome analyses than a genome-wide association study. Moreover, recently published genomic studies [ 57 , 58 ] contained smaller number of participants than our study. Replication with a larger sample is necessary.…”

Section: Discussionmentioning

confidence: 96%

Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome

et al. 2016

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BackgroundCorticotropin-releasing hormone (CRH) plays an important role in the pathophysiology of irritable bowel syndrome (IBS) and regulates the stress response through two CRH receptors (R1 and R2). Previously, we reported that a CRHR1 gene polymorphism (rs110402, rs242924, and rs7209436) and haplotypes were associated with IBS. However, the association between the CRHR2 gene and IBS was not investigated. We tested the hypothesis that genetic polymorphisms and haplotypes of CRHR2 are associated with IBS pathophysiology and negative emotion in IBS patients.MethodsA total of 142 IBS patients and 142 healthy controls participated in this study. Seven single nucleotide polymorphisms (SNPs) of the CRHR2 gene (rs4722999, rs3779250, rs2240403, rs2267710, rs2190242, rs2284217, and rs2284220) were genotyped. Subjects' psychological states were evaluated using the Perceived-Stress Scale, the State-Trait Anxiety Inventory, and the Self-Rating Depression Scale.ResultsWe found that rs4722999 and rs3779250, located in intronic region, were associated with IBS in terms of genotype frequency (rs4722999: P = 0.037; rs3779250: P = 0.017) and that the distribution of the major allele was significantly different between patients and controls. There was a significant group effect (controls vs. IBS), and a CRHR2 genotype effect was observed for three psychological scores, but the interaction was not significant. We found a haplotype of four SNPs (rs4722999, rs3779250, rs2240403, and rs2267710) and two SNPs (rs2284217 and rs2284220) in strong linkage disequilibrium (D′ > 0.90). We also found that haplotypes of the CRHR2 gene were significantly different between IBS patients and controls and that they were associated with negative emotion.ConclusionOur findings support the hypothesis that genetic polymorphisms and haplotypes of CRHR2 are related to IBS. In addition, we found associations between CRHR2 genotypes and haplotypes and negative emotion in IBS patients and controls. Further studies on IBS and the CRH system are warranted.

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Section: Discussionmentioning

confidence: 96%

Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome

et al. 2016

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Does frequency of restless legs syndrome and poor sleep quality increase with age in irritable bowel syndrome?

Acay

Bal

Oruç

et al. 2016

Wien Klin Wochenschr

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HLA-DQ and alcohol in the pathogenesis of irritable bowel syndrome in college students: a case–control study

Liu

Huang²,

et al. 2023

Sci Rep

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Some researchers have shown that genetics contribute to the incidence of IBS. However, no research has focused on the interaction between HLA-DQ and living habits in the pathogenesis of IBS. The present study explored the risk factors for IBS in college students of Guangxi Han nationality and explored the interaction between HLA-DQ and living habits on the pathogenesis of IBS. Univariate and multivariate analyses were used to determine the risk factors for IBS. Logistic interaction analysis and the Excel table made by Andersson were used to explore the interaction between genes and living habits in the context of IBS. We found that low expression of HLA-DQ2 and DQ8 were associated with the pathogenesis of IBS, while mild to moderate alcohol consumption was associated with the occurrence of IBS symptoms. Only the HLA-DQ8 gene and alcohol consumption had additive interactions in the context of the occurrence of IBS. In other words, for college students of Guangxi Han nationality, HLA-DQ2 and HLA-DQ8 might be protective against IBS, while alcohol consumption might be an independent risk factor. There was an additive interaction between HLA-DQ8 and alcohol consumption in the occurrence of IBS.

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Correlation between DQB1 genetic polymorphism and genetic susceptibility in patients diagnosed with irritable bowel syndrome with diarrhea

Cited by 3 publications

References 19 publications

Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome

Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome

Does frequency of restless legs syndrome and poor sleep quality increase with age in irritable bowel syndrome?

HLA-DQ and alcohol in the pathogenesis of irritable bowel syndrome in college students: a case–control study

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