Correlation between dominant EEG frequency, cerebral oxygen uptake and blood flow

Ingvar, David H.; Sjölund, Bengt H.; Ardö, Anders

doi:10.1016/0013-4694(76)90119-x

Cited by 207 publications

(66 citation statements)

References 23 publications

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“…A slowing of EEG activity correlates with reduced blood flow and glucose utilization. These results have been considered the electrophysiological equivalents of hypofrontality 9,13 . Indeed, long before the concept of hypo-frontality became popular, Lemere 14 described a slowing of EEG activity in schizophrenic patients, especially those with a deteriorating course of illness.…”

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confidence: 99%

Neurocortical electrical activity tomography in chronic schizophrenics

Veiga

Deslandes

Cagy

et al. 2003

Arq. Neuro-Psiquiatr.

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-Functional imaging of brain electrical activity was performed in 25 chronic medicated schizophrenics and 40 controls, analyzing the classical frequency bands (delta, theta, alpha, and beta) of 19-channel EEG during resting state to identify brain regions with deviant activity of different functional significances, using LORETA (Low Resolution Tomography) and SPM99 (Statistical Parametric Mapping). Patients differed from controls due to an excess of slow activity comprising delta + theta frequency bands (inhibitory pattern) located at the right middle frontal gyrus, right inferior frontal gyrus, and right insula, as well as at the bilateral anterior cingulum with a left preponderance. The high temporal resolution of EEG enables the specification of the deviations not only as an excess or a deficit of brain electrical activity, but also as inhibitory (delta, theta), normal (alpha), and excitatory (beta) activities. These deviations point out to an impaired functional brain state consisting of inhibited frontal and prefrontal areas that may result in inadequate treatment of externally or internally generated information.KEY WORDS: brain mapping, EEG, LORETA (low resolution electromagnetic tomography), schizophrenia.Atividade elétrica neurocortical em esquizofrênicos crônicos Atividade elétrica neurocortical em esquizofrênicos crônicos Atividade elétrica neurocortical em esquizofrênicos crônicos Atividade elétrica neurocortical em esquizofrênicos crônicos Atividade elétrica neurocortical em esquizofrênicos crônicos RESUMO -Imagens funcionais da atividade elétrica cerebral de 25 esquizofrênicos crônicos medicados e de 40 controles foram obtidas através do registro (19 canais) e da análise das faixas tradicionais (delta, teta, alfa e beta) do EEG, durante o repouso vigil. O objetivo foi identificar regiões do cérebro que apresentassem desvios com diferentes significados funcionais na 'Low Resolution Electromagnetic Tomography' (LORETA) e no 'Statistical Parametric Mapping' (SPM). Observou-se excesso de atividade lenta nas faixas delta + teta (padrão inibitório) nos pacientes esquizofrênicos, localizado no giro frontal médio direito, no giro frontal inferior direito e na insula direita e, também, na porção anterior do giro do cíngulo, bilateralmente, mas com predomínio à esquerda. A alta resolução temporal do EEG permite especificar os desvios em termos de excesso ou déficit de atividade elétrica cerebral, bem como de atividades com um padrão inibitório (delta, teta), normal (alfa) e excitatório (beta). Os desvios encontrados apontam para comprometimento funcional cerebral que consiste no predomínio de atividade inibitória nas áreas frontais e pré-frontais que pode causar processamento inadequado de informações, quer de origem externa quanto interna. PALAVRAS-CHAVE: mapeamento cerebral, eletroencefalografia quantitativa (EEGq), LORETA (tomografia de baixa resolução), esquizofrenia.

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confidence: 99%

Neurocortical electrical activity tomography in chronic schizophrenics

Veiga

Deslandes

Cagy

et al. 2003

Arq. Neuro-Psiquiatr.

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“…In the adult human and in experimental research on adult animals, EEG activity correlated with both cerebral metabolic activity and cerebral blood flow (12,13). Whether this correlation is present also in newborn infants has not previously been investigated, although one study on mechanically ventilated preterm infants showed that aEEG burst density during the first days of life correlated with CBF (14).…”

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Cerebral Glucose Metabolism and Early EEG/aEEG in Term Newborn Infants with Hypoxic-Ischemic Encephalopathy

et al. 2003

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The objective was to investigate how early electrocortical background pattern, as recorded with amplitude integrated EEG (aEEG), correlates with global and regional cerebral glucose metabolism (CMRgl) measured by positron emission tomography during the subacute phase after birth asphyxia. Nineteen term infants with hypoxic-ischemic encephalopathy were investigated. The aEEG background was evaluated at 0 -6, 6 -12, 12-24, 24 -48, and 48 -72 h postnatal age, and classified into four categories according to increasing degree of abnormality. The aEEG were also evaluated for sleep-wake cycling and epileptic seizure activity. CMRgl was measured by positron emission tomography with 2-( 18 F) fluoro-2-deoxy-D-glucose at a median (range) postnatal age 10 (4 -24) d. Increasing degree of abnormality in aEEG correlated significantly with decreasing CMRgl: at 6 -12 h (Ϫ0.593; 0.012) (r value; p value), 12-24 h (Ϫ0.669; 0.003), and 24 -48 h (Ϫ0.569; 0.014) postnatal age. Presence of sleep-wake cycling at 0 -6 h (0.697; 0.012), 6 -12 h (0.668; 0.003), and 12-24 h (0.612; 0.009) of age correlated with increased CMRgl. Delayed seizure activity at 12-24 h correlated with decreased CMRgl (Ϫ0.661; 0.004). Infants with abnormal aEEG at 6 -12 h had lower CMRgl in all regions of the brain compared with infants with normal aEEG. CMRgl of any specific region of the brain was not significantly more correlated to aEEG than CMRgl of other regions. Early electrocortical background patterns, early presence of sleep-wake cycling, and delayed seizure activity were highly correlated with global CMRgl measured during the subacute phase after asphyxia, but did not correlate with any specific pattern of regional uptake. Abbreviations aEEG, amplitude integrated EEG BS, burst-suppression aEEG CMRgl, cerebral metabolic rate of glucose CP, cerebral palsy FDG, fluoro-deoxyglucose HIE, hypoxic-ischemic encephalopathy OM, orbito-meatal PET, positron emission tomography rCMRgl, regional cerebral metabolic rate of glucose ROI, region of interest SWC, sleep-wake cycling in aEEG SZA, epileptic seizure activity in aEEG Birth asphyxia in term newborn infants remains a considerable problem in perinatal medicine, with high risk of mortality and disability (1-3). To predict outcome, the clinical neurologic assessment in grading HIE has proved to be of great value during the first days of life (4 -6). We have recently shown that CMRgl is significantly lower in asphyxiated full-term infants who die or develop CP than in asphyxiated infants with no signs of impairment at follow up (7). To select infants for early cerebroprotective treatment, which is a likely option in the near future (8), specific methods are required for very early identification of the infants who are at the highest risk of becoming disabled. aEEG has been used for very early prediction of outcome in full-term infants after birth asphyxia. There is a high risk for neurologic injury when the background aEEG is abnormal during the first hours of life (9, 10).On postmortem examinations of newborn in...

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“…Применяли разработанный в лаборатории клини-ческой нейрофизиологии адаптивный метод определения частотных границ ритмов ЭЭГ [42]. С помощью этого ме-тода в частотной полосе 1-70 Гц было выделено 12 ча-стотных диапазонов (ритмы): δ (1,1-4,1 Гц), θ1 (4,1-6,1 Гц), θ2 (6,1-8,1 Гц), α1 (8,1-9,8 Гц), α2 (9,(8)(9)(10)(11)4 Гц), α3 (11,4-13,0 Гц), β1 (13,0-15,6 Гц), β2 (15,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20),0 Гц), β3 (20,0-24,4 Гц), β4 (24,7 Гц), γ1 (30,7-48,8 Гц), γ2 (Гц 51,0-57,7). Полученные диапазоны отражали адек-ватное исследуемой выборке и состояниям деление спек-тра ЭЭГ на независимые, мало коррелированные ритмы, что оптимизировало количество необходимых для иссле-дования показателей.…”

Section: материал и методыunclassified

“…Часто оно преобладает в лобных отделах [3][4][5], свидетельствуя о снижении уровня их активации (гипоактивация). Связь этих изменений со снижением кровотока и утилизации глюкозы во фронтальной коре дает основание для их интерпретации как электрофизио-логического эквивалента обусловленной изменением об-мена гипофронтальности [6,7]. Данные позитронно-эмиссионной томографии свидетельствуют, что при ши-зофрении гипофронтальность отражает дисфункцию пре-фронтальной коры [8,9].…”

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EEG frequency and regional properties in patients with paranoid schizophrenia: effects of positive and negative symptomatology prevalence

Bochkarev

Kirenskaya

Tkachenko

et al. 2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Correlation between dominant EEG frequency, cerebral oxygen uptake and blood flow

Cited by 207 publications

References 23 publications

Neurocortical electrical activity tomography in chronic schizophrenics

Neurocortical electrical activity tomography in chronic schizophrenics

Cerebral Glucose Metabolism and Early EEG/aEEG in Term Newborn Infants with Hypoxic-Ischemic Encephalopathy

EEG frequency and regional properties in patients with paranoid schizophrenia: effects of positive and negative symptomatology prevalence

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Correlation between dominant EEG frequency, cerebral oxygen uptake and blood flow

Cited by 207 publications

References 23 publications

Neurocortical electrical activity tomography in chronic schizophrenics

Neurocortical electrical activity tomography in chronic schizophrenics

Cerebral Glucose Metabolism and Early EEG/aEEG in Term Newborn Infants with Hypoxic-Ischemic Encephalopathy

EEG frequency and regional properties in patients with paranoid schizophrenia: effects of positive and negative symptomatology pre­valence

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EEG frequency and regional properties in patients with paranoid schizophrenia: effects of positive and negative symptomatology prevalence