Correlation Between Distal Left Anterior Descending Artery Flow Velocity by Transthoracic Doppler Echocardiography and Corrected TIMI Frame Count Before Mechanical Reperfusion in Patients With Anterior Acute Myocardial Infarction

Lee, Souki; Minagoe, Shinichi; Hamasaki, Shuichi; Toyonaga, Kenji; Obata, Hachiro; Takumi, Takuro; Arimura, Hiroshi; Miyata, Masaaki; Biro, Sadatoshi; Toda, Hitoshi

doi:10.1253/circj.69.1022

Cited by 11 publications

(13 citation statements)

References 42 publications

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“…More recently, in a preliminary study on EECP and CSF, we showed that coronary flow indices by TTDE correlated well with angiographic estimation of coronary flow [12]. The present study demonstrated that there was an excellent inverse correlation between resting DPFV and TFC for LAD (r = –0.821, p < 0.001), and CFR was inversely correlated with the mean TFC (r = –0.549, p < 0.001), which is consistent with our previous report and the results reported by Lee et al [18] and Caliskan et al [19]. These results suggested that CFV and CFR measured by TTDE could be reliable indices for assessing coronary flow in patients with CSF.…”

Section: Discussionsupporting

confidence: 92%

“…In these patients, coronary blood flow has often been quantitatively evaluated by TFC on coronary angiography [1,13,14], which is invasive and expensive, limiting its use in the clinical setting. TTDE is a noninvasive, relatively inexpensive and widely used method for measuring CFV and CFR in the distal LAD [18,19,20]. To our knowledge, however, the correlations between CFV measured by TTDE and angiographic TFC have not been fully elucidated in patients with CSF, although in a previous study in patients with anterior acute myocardial infarction before mechanical reperfusion [18], DPFV of the distal LAD by TTDE showed a significant correlation with corrected TFC by angiography (r = –0.74, p < 0.001), and Caliskan et al [19] reported a strong inverse correlation between TFC and CFR in patients with CSF (r = –0.62, p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

“…TTDE is a noninvasive, relatively inexpensive and widely used method for measuring CFV and CFR in the distal LAD [18,19,20]. To our knowledge, however, the correlations between CFV measured by TTDE and angiographic TFC have not been fully elucidated in patients with CSF, although in a previous study in patients with anterior acute myocardial infarction before mechanical reperfusion [18], DPFV of the distal LAD by TTDE showed a significant correlation with corrected TFC by angiography (r = –0.74, p < 0.001), and Caliskan et al [19] reported a strong inverse correlation between TFC and CFR in patients with CSF (r = –0.62, p < 0.001). More recently, in a preliminary study on EECP and CSF, we showed that coronary flow indices by TTDE correlated well with angiographic estimation of coronary flow [12].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Enhanced External Counterpulsation on Coronary Slow Flow and Its Relation with Endothelial Function and Inflammation: A Mid-Term Follow-Up Study

Luo¹,

Liu

Wu³

et al. 2012

Cardiology

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Background: Although enhanced external counterpulsation (EECP) showed short-term effects in improving coronary flow in patients with coronary slow flow (CSF), whether such improvement is durable remains uncertain, and the relationships between such improvement and changes in endothelial function as well as inflammatory markers have not been elucidated. Objectives: The aim of the present study was to investigate the effects of EECP on transthoracic coronary flow, flow-mediated dilatation (FMD), and high-sensitivity C-reactive protein (hsCRP) in patients with CSF. Methods: Forty-five patients with documented CSF underwent transthoracic Doppler echocardiography (TTDE) for the assessment of coronary diastolic peak flow velocity (DPFV) and coronary flow reserve (CFR), and measurements of FMD and hsCRP; they were then nonrandomly assigned to two groups. Subjects in the control group (n = 24) received only medical therapy, and those in the EECP group (n = 21) were additionally treated with the 36 one-hour sessions of EECP. After 8 weeks of medical/EECP therapy, TTDE, FMD, and hsCRP examinations were repeated, and TTDE was additionally repeated after the 6-month clinical follow-up. Results: In the EECP group, resting DPFV, hyperemic DPFV, and CFR were significantly increased shortly after therapy (p < 0.001) and the improvement was maintained up to the 6-month follow-up, whereas in the control group those variables were not statistically increased. Meanwhile, hsCRP significantly decreased and FMD increased after therapy in the EECP group (p < 0.001). In all subjects, CFR improvement was negatively correlated with hsCRP change and positively correlated with FMD increase (p < 0.001). Conclusions: EECP may have a durable effect in improving coronary flow in patients with CSF. Such improvement is related to the favorable effects of EECP on vascular inflammation and endothelial function.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Enhanced External Counterpulsation on Coronary Slow Flow and Its Relation with Endothelial Function and Inflammation: A Mid-Term Follow-Up Study

Luo¹,

Liu

Wu³

et al. 2012

Cardiology

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“…The CTFC method yields results that are concordant with other diagnostic modalities including transthoracic Doppler echocardiography (TTDE), single photon emission computerized tomography (SPECT), magnetic resonance imaging (MRI), intravascular ultrasound (IVUS) and intracoronary Doppler and pressure measurements [29][30][31][32]. Diastolic peak velocity of the distal LAD flow measured by pulsed TTDE has demonstrated a significant correlation with the CTFC (r = -0.74, P \ 0.001).…”

Section: Concordance Between the Ctfc And Other Imaging Modalitiesmentioning

confidence: 74%

Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years

Kunadian

Harrigan

Zorkun

et al. 2008

J Thromb Thrombolysis

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“…Recently, the transthoracic Doppler echocardiography (TTDE) technique has emerged to take reliable measurements of the CFV and CFV reserve (CFVR) in the left anterior descending artery (LAD) using intravenous administration of adenosine 5'-triphosphate (ATP). [7][8][9] Accordingly, we evaluated the usefulness of TTDE for the non-invasive assessment of the coronary arterial tone in human LAD.…”

mentioning

confidence: 99%

Non-Invasive Assessment of Coronary Arterial Tone Using Trans-Thoracic Doppler Echocardiography

Takagi

Tsurumi

Arai

et al. 2006

Circ J

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oronary arterial tone impacts the frequency and the threshold of angina attack in patients with coronary artery disease. 1,2 The basal coronary arterial tone is known to be increased in patients with coronary spastic angina (CSA). 3,4 The high arterial tone is associated with the hyper-sensitive response to the intracoronary injection of acetylcholine or ergonovine in patients with CSA. 4 However, it has been difficult to non-invasively assess the coronary arterial tone. 5 As the coronary flow velocity (CFV) is inversely related to the luminal size that exists for the distal myocardial bed, 6 the elevated basal arterial tone can be assessed as the higher flow velocity in the epicardial artery. Recently, the transthoracic Doppler echocardiography (TTDE) technique has emerged to take reliable measurements of the CFV and CFV reserve (CFVR) in the left anterior descending artery (LAD) using intravenous administration of adenosine 5'-triphosphate (ATP). 7-9 Accordingly, we evaluated the usefulness of TTDE for the non-invasive assessment of the coronary arterial tone in human LAD. Methods Study Patients and Study DesignWe studied 32 consecutive patients with chest pain at rest who underwent a coronary angiography and had no Circulation Journal Vol.70, April 2006 significant stenoses. Two patients were excluded because of the suboptimal measurements in TTDE. A total of 30 patients (age 40 to 77 years, mean 59.8±9.3 years old, 21 male, 9 female) were included for further analysis.The Institutional Review Board approved the study, and the patients provided written informed consent. Vasodilators were withdrawn at least 72 h before the study, except sublingual nitroglycerin (NTG), which was withdrawn at least 2 h before the study. The patients fasted overnight and did not smoke within 2 h prior to the study. All foods or drinks containing flavonoid or catechins were withheld during the study. The Doppler examinations were performed in the morning. The Doppler echocardiographic measurements were conducted before and 3 min after the oral administration of NTG. CFV MeasurementsTTDE was performed with a 5 MHz transducer connected to a Vivid 7 echocardiographic machine (GEVingmed Ultrasound, Horton, Norway), by an experienced investigator. The distal LAD was examined by using color Doppler mapping with a velocity range from -15 to +15 cm/s. After positioning a sample volume where the ultrasonic beam was as parallel to the direction of the distal LAD as possible, the spectral Doppler signal was recorded by fast Fourier transformation analysis for the baseline measurement. Thereafter, Doppler signals were obtained under the maximal hyperemic conditions during the intravenous infusion of ATP at the speed of 0.14 mg· kg -1 · min -1 . Images were stored on a 5-inch MO disk for offline analysis. The mean diastolic flow velocity was traced for the CFV measurements. The measurements were averaged over 3 cardiac cycles. The CFVR was calculated as the

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Correlation Between Distal Left Anterior Descending Artery Flow Velocity by Transthoracic Doppler Echocardiography and Corrected TIMI Frame Count Before Mechanical Reperfusion in Patients With Anterior Acute Myocardial Infarction

Cited by 11 publications

References 42 publications

Effect of Enhanced External Counterpulsation on Coronary Slow Flow and Its Relation with Endothelial Function and Inflammation: A Mid-Term Follow-Up Study

Effect of Enhanced External Counterpulsation on Coronary Slow Flow and Its Relation with Endothelial Function and Inflammation: A Mid-Term Follow-Up Study

Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years

Non-Invasive Assessment of Coronary Arterial Tone Using Trans-Thoracic Doppler Echocardiography

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