Correlation Between Disease Severity and Presence of Ocular Autoantibodies in Juvenile Idiopathic Arthritis-Associated Uveitis

Abstract

In JIAU patients, antiocular serum antibodies can be detected more frequently than in control groups. Binding patterns to ocular tissue correlate with complicated uveitis course but not with uveitis activity and anti-inflammatory treatment. Antibody binding is not specific for this uveitis entity, and does not correlate with ANA positivity.

Elevated S100A8/A9 and S100A12 Serum Levels Reflect Intraocular Inflammation in Juvenile Idiopathic Arthritis-Associated Uveitis: Results From a Pilot Study

“…Additionally, numerous studies have demonstrated systemically circulating autoantibodies presumably produced by extraocularly located plasma cells, and it is known that systemically circulating ANA are a major risk factor for developing uveitis in JIA. [33][34][35][36][37][38] In line with those findings, our data support the notion of uveitis being an organ-specific manifestation of a systemic immune dysregulation, which can be accompanied by (subclinical) systemic inflammation. This hypothesis was raised previously by Olson et al 23 reporting on elevated serum calprotectin levels in six adult patients with active endogenous posterior uveitis.…”

Managing juvenile idiopathic arthritis–associated uveitis

“…40 Walscheid et al described how antiocular serum antibodies to ocular cryosections from swine eyes were detected more frequently in JIA-associated uveitis than in control groups, correlating with a complicated uveitis course but not with uveitis activity or antiinflammatory treatment. 41 Similarly, it has been also reported higher levels of transthyretin are present in the aqueous of patients with JIA-associated uveitis and silent chronic anterior uveitis compared to those of the other uveitis types and control groups. 42 Recently, a study has shown an association between parvovirus B19 and JIAassociated uveitis.…”

Uveitis associated with juvenile idiopathic arthritis

“…A similar study looked at antibody binding to sections of swine eyes after incubation with sera from children with JIA-associated uveitis, JIA without uveitis, idiopathic anterior uveitis or healthy controls. 61 In the patients with JIAassociated uveitis, antibody binding was predominantly to the iris (in 74%) and ciliary body (79%). Antibody binding showed a statistically significant correlation with the prevalence of ocular complications.…”