Correlation between desynchrony of hippocampal neural activity and hyperlocomotion in the model mice of schizophrenia and therapeutic effects of aripiprazole
Xueru Wang,
Zijie Li,
Shihui Kuai
et al.
Abstract:AimsThe hippocampus has been reported to be morphologically and neurochemically altered in schizophrenia (SZ). Hyperlocomotion is a characteristic SZ‐associated behavioral phenotype, which is associated with dysregulated dopamine system function induced by hippocampal hyperactivity. However, the neural mechanism of hippocampus underlying hyperlocomotion remains largely unclear.MethodsMouse pups were injected with N‐methyl‐D‐aspartate receptor antagonist (MK‐801) or vehicle twice daily on postnatal days (PND) 7… Show more
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