Correlation between depressive symptoms and nocturnal disturbances in Japanese patients with Parkinson's disease

Suzuki, Keisuke; Miyamoto, Masayuki; Miyamoto, Tomoyuki; Okuma, Yasuyuki; Hattori, Nobutaka; Kamei, Satoshi; Yoshii, Fumihito; Utsumi, Hiroya; Iwasaki, Yasuo; Iijima, Makoto; Hirata, Koichi

doi:10.1016/j.parkreldis.2008.02.002

Cited by 49 publications

(65 citation statements)

References 25 publications

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“…Regarding the convergent validity of the PDSS-2, the PDSS-2 total score correlated significantly with sleep disturbances as measured by the PSQI global and the PSQI component scores, daytime sleepiness, fatigue and quality of life. Both the PDSS-2 total and domain scores showed strong correlations with the BDI-II, PDQ-39 SI and with most of the PDQ-39 domains, which is consistent with previous studies showing a significant relationship between sleep disorders, depression and quality of life [19,[34][35][36]. In this study, both the PDSS-2 total and domain scores had mild to moderate correlations with the PFS.…”

Section: Discussionsupporting

confidence: 92%

“…The PDSS includes 15 questions regarding PD-related nocturnal symptoms and is widely used as a recommended, valid and highly reliable scale in comparison to other scales for sleep [13,14,[16][17][18]. Previously, we performed a multicenter study and found that more severe nocturnal disturbances, as measured by the PDSS, in patients with an advanced stage of PD, have a higher association with depressive symptoms compared with those at early and moderate stages of the disease [14,19]. Recently, the PDSS-2, a revised version of the PDSS, has been published to address the frequency of nocturnal symptoms observed in PD patients and to screen for SAS [20].…”

Section: Introductionmentioning

confidence: 99%

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Nocturnal disturbances and restlessness in Parkinson's disease: Using the Japanese version of the Parkinson's disease sleep scale-2

Suzuki

Miyamoto

et al. 2012

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Nocturnal disturbances and restlessness in Parkinson's disease: Using the Japanese version of the Parkinson's disease sleep scale-2

Suzuki

Miyamoto

et al. 2012

Journal of the Neurological Sciences

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“…A correlation between total PDSS scores and measures of anxiety and depression was reported in previous studies [21,24], and PDSS score has been recently identified as significant determinant of depression in PD patients [25].…”

Section: Discussionsupporting

confidence: 54%

Observational study of sleep-related disorders in Italian patients with Parkinson’s disease: usefulness of the Italian version of Parkinson’s disease sleep scale

et al. 2011

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Sleep disturbances are common in patients with Parkinson's disease (PD). We aimed to evaluate prevalence and severity of nighttime sleep disturbances in Italian PD patients and to validate the Italian version of the Parkinson's disease sleep scale. A total of 221 PD patients and 57 healthy controls participated in a cross-sectional study with retest. PDSS, Epworth Sleepiness Scale (ESS), Hamilton Depression Rating Scale, Unified Parkinson's Disease Rating Scale (UPDRS), and Hoehn and Yahr staging were applied. PDSS total and individual items scores from patients were significantly lower than those in controls. Internal consistency of PDSS scale was satisfactory and intraclass correlation coefficient for test-retest reliability was 0.96 for total PDSS score. A significant negative correlation was found between total PDSS and ESS scores, and between total PDSS and HDRS scores. PDSS scores were also related to UPDRS sections II, III and IV, and H&Y stage. PDSS and ESS scores were not related to levodopa equivalent dose. Daytime sleepiness, depressive symptoms and disease severity correlate with sleep disturbances in Italian PD patients. The PDSS is a valid and reliable tool to evaluate sleep disturbances in Italian patients.

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“…The correlation between the Epworth and the PDSS scales was not as strong as we anticipated [4,20]; in our case, the correlation coefficient is low (0.17) and not significant. A previous study has found a strong correlation between sleep disorders as measured by PDSS and depressive symptoms [31]. Other studies have found a relationship between the presence of cognitive impairment and REM behavior disorder (RBD), suggesting that the presence of RBD in PD is a major risk factor for MCI [11].…”

Section: Discussionmentioning

confidence: 98%

Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson’s disease

et al. 2010

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The objective of this study is to assess how the non-motor symptoms of Parkinson's disease (PD), such as depression, cognitive deterioration, neuropsychiatric and sleep disorders, affect the quality of life, and to compare them with the motor symptoms in order to determine their real impact. A cross-sectional study was designed including 99 patients (mean age 68.5 ± 9.9 years, duration of disease 8.7 ± 6.2 years). Demographic data, onset of PD, years on treatment with levodopa (LD), class of dopaminergic drug prescribed, and dosages were obtained. The following scales were used: quality of life (PDQ-39), Unified Parkinson's Disease Rating Scale (UPDRS I-IV), Parkinson Disease Sleep Scale (PDSS) and daytime sleepiness (Epworth), Mini-Mental State Examination, depression (HAM-D), and the neuropsychiatric inventory (NPI-10). The PDQ-39 summary index (PDQ-39 SI) was 24.7 ± 13.2. A linear regression model including all variables showed that four independent variables accounted for 67.2% of the variance in the PDQ-39 SI (F = 33,277; p < 0.001): NPI, PDSS, UPDRS IV, and UPDRS I. When sub-items of the NPI, PDSS and UPDRS IV scales are analyzed, significant correlations (p < 0.001) are found between the PDQ-39 SI and depression, agitation, apathy, anxiety, hallucinations, delusions, incontinence of urine, morning painful posturing, restlessness in bed, morning fatigue, duration of off periods, unpredictable and predictable off periods, early morning dystonia, and sudden off periods. Neuropsychiatric symptoms, especially depression, nighttime sleep disorders such as urinary incontinence, nighttime restlessness, morning fatigue and somnolence, off-period dystonia and motor fluctuations are the variables that most affect the quality of life of patients with PD.

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Correlation between depressive symptoms and nocturnal disturbances in Japanese patients with Parkinson's disease

Cited by 49 publications

References 25 publications

Nocturnal disturbances and restlessness in Parkinson's disease: Using the Japanese version of the Parkinson's disease sleep scale-2

Nocturnal disturbances and restlessness in Parkinson's disease: Using the Japanese version of the Parkinson's disease sleep scale-2

Observational study of sleep-related disorders in Italian patients with Parkinson’s disease: usefulness of the Italian version of Parkinson’s disease sleep scale

Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson’s disease

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