Correlation Between Cyclo-oxygenase-2 and Vascular Endothelial Growth Factor Expression in Canine and Feline Squamous Cell Carcinomas

Millanta, Francesca; Andreani, Giacomo; Rocchigiani, Guido; Lorenzi, Davide De; Poli, Alessandro

doi:10.1016/j.jcpa.2016.02.005

Cited by 19 publications

(22 citation statements)

References 23 publications

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“…NSAIDs were utilized in 42 dogs (21.8%) as part of their treatment within this population. In one study, 87.5% (7/8) of dogs with cutaneous SCC were found to have positivity for cyclo‐oxygenase‐2 (COX‐2) expression and 100% (9/9) in another study . Additionally, COX‐2 expression has also been identified in canine cases of actinic keratosis, and therapy with NSAIDs provided improvement in 4/5 dogs .…”

Section: Discussionmentioning

confidence: 99%

“…In one study, 87.5% (7/8) of dogs with cutaneous SCC were found to have positivity for cyclo-oxygenase-2 (COX-2) expression and 100% (9/9) in another study. 56,57 Additionally, COX-2 expression has also been identified in canine cases of actinic keratosis, and therapy with NSAIDs provided improvement in 4/5 dogs. 32,56,57 NSAIDs have also been used in people with actinic keratosis with some efficacy as a topical therapy.…”

Section: Discussionmentioning

confidence: 99%

“…56,57 Additionally, COX-2 expression has also been identified in canine cases of actinic keratosis, and therapy with NSAIDs provided improvement in 4/5 dogs. 32,56,57 NSAIDs have also been used in people with actinic keratosis with some efficacy as a topical therapy. 58 Although it is difficult to draw conclusions from NSAID usage in this study, there is the impetus for future studies investigating the role of NSAIDs as chemoprevention for solar UV-radiation associated SCC in dogs.…”

Section: Discussionmentioning

confidence: 99%

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Clinical features and outcome of dermal squamous cell carcinoma in 193 dogs (1987‐2017)

Willcox

Marks

Ueda

et al. 2019

Vet Comparative Oncology

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Squamous cell carcinoma (SCC) is a frequently recognized dermal tumour in dogs and has been described as a common pathology induced by solar ultraviolet radiation exposure. Little has been published about this neoplasm with regard to clinical features and outcome in dogs. This retrospective study included 193 dogs from a single institution histopathologically diagnosed with SCC of the dermis. Thirty‐eight percent of all dogs had documented histopathologic actinic change. The overall median survival time was 1004 days, with the population demonstrating actinic change associated with a significantly longer survival time (median 1359 days, range 16‐3530 days) compared to dogs without actinic change (median 680 days, range 16‐3066 days) and this achieved significance on multivariate analysis (hazard ratio 0.42, 95% confidence interval 0.193‐0.930, P = 0.032). These data demonstrate increased survival of dogs with SCC demonstrating actinic change over those with non‐actinic SCCs, and purports long‐term survival for these animals. Dogs received a variety of treatment approaches as a retrospective study, and future prospective studies will be necessary to investigate whether adjunct therapies such as radiation or chemotherapy offer improvement in survival for dermal SCC in the dog.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical features and outcome of dermal squamous cell carcinoma in 193 dogs (1987‐2017)

Willcox

Marks

Ueda

et al. 2019

Vet Comparative Oncology

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“…Cyclooxygenase-2 (COX-2) is dramatically upregulated during occurrence, growth and spread of cancers by modulating the production of angiogenic factors (Abdelall & Kamel, 2016), and COX-2 inhibitors have been used as efficient agents to treat cancers (Millanta et al, 2016). Study showed that catechins separated from green tea exhibited efficiently inhibitory effect on COX-2 in vitro (Deng et al, 2014), implying that inhibition of catechins on COX-2 activity might be involved in anticancer property of tea.…”

Section: Enzymes Related To Cancersmentioning

confidence: 99%

Stop for tea? Enzyme inhibitors from tea – what good are they?

Zhao

et al. 2016

Int J of Food Sci Tech

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Summary Tea possesses many bioactive components including polyphenols, theanine and caffeine. Inhibitory effect of these components on the various enzymes involved in some chronic diseases was reviewed in this study. Many studies revealed that anti‐obesity of tea was mainly ascribed to the polyphenols which could inhibit the activity of the enzymes related to diet metabolism such as α‐amylase, α‐glucosidase and lipase. Inhibitory effect of catechins and caffeine against β‐ and γ‐secretase, acetylcholinesterase, protein kinase C and histone deacetylase might be responsible for the prevention from nervous system diseases. Cytochrome P450 enzymes, cytosolic sulfotransferases, cyclooxygenase‐2 and phosphoinositide‐3‐kinase could be efficiently suppressed by catechins, which would decrease the risk of cancer initiation and proliferation; theanine could lower the activity of some anticarcinogen‐activated enzymes and alleviate the adverse effect of cancer cure. Catechins and caffeine exhibited significant inhibition against the matrix metalloproteinases, histidine decarboxylase and many kinases related to inflammation. Thus, catechins, theanine and caffeine might be employed as inhibitors of the enzymes associated with these chronic diseases.

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“…Em nosso estudo, a raça mais acometida foi a American PitBull Terrier, condizendo com a literatura (North;Banks, 2009;Costa, 2009;Vail;Withrow, 2007;Poggiani et al, 2012). As regiões anatômicas mais acometidas pela doença são locais com menor cobertura de pelos, como face interna de membros, plano nasal, pina de orelhas e abdome como descrito em nosso estudo (Almeida et al, 2001, Carvalho, 2008Milanta et al, 2016).…”

Section: Análise Estatísticaunclassified

Estudo comparativo dos aspectos clínicos, morfológicos e moleculares da ceratose actínica e do carcinoma de células escamosas na pele da região ventral abdominal de caninos domésticos

Zanini¹

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Correlation Between Cyclo-oxygenase-2 and Vascular Endothelial Growth Factor Expression in Canine and Feline Squamous Cell Carcinomas

Cited by 19 publications

References 23 publications

Clinical features and outcome of dermal squamous cell carcinoma in 193 dogs (1987‐2017)

Clinical features and outcome of dermal squamous cell carcinoma in 193 dogs (1987‐2017)

Stop for tea? Enzyme inhibitors from tea – what good are they?

Estudo comparativo dos aspectos clínicos, morfológicos e moleculares da ceratose actínica e do carcinoma de células escamosas na pele da região ventral abdominal de caninos domésticos

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