Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression

Tafet, Gustavo E.; Idoyaga-Vargas, Víctor; Abulafia, Denise P.; Calandria, Jorgelina M.; Roffman, Silvia S.; Chiovetta, Amabella; Shinitzky, Meir

doi:10.3758/cabn.1.4.388

Cited by 80 publications

(51 citation statements)

References 45 publications

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“…This constitutes a highly prevalent condition, characterized by excessive anxiety and worry about various life events, implying an important source of subjective distress during a certain period of time (American Psychiatric Association, 1994). This may cause hyperactivation of the HPA axis, as we observed in a previous study in which a group of patients with GAD presented increased levels of circulating cortisol, similar to those observed in a group of patients with major depression (MDD; Tafet, Idoyaga-Vargas, et al, 2001).…”

supporting

confidence: 62%

Regulation of hypothalamic-pituitary-adrenal activity in response to cognitive therapy in patients with generalized anxiety disorder

Tafet

Feder

Abulafia

et al. 2005

Cognitive, Affective, & Behavioral Neuroscience

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supporting

confidence: 62%

Regulation of hypothalamic-pituitary-adrenal activity in response to cognitive therapy in patients with generalized anxiety disorder

Tafet

Feder

Abulafia

et al. 2005

Cognitive, Affective, & Behavioral Neuroscience

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“…It has been shown that plasma serotonin and cortisol levels are directly associated with depression and decreased locomotor activity [17], [18], [24], [36]–[38], [44], and may also be associated with depression in smokers and patients with COPD [45]–[49]. We have recently reported that acute (3 d), sub-chronic (10 d) and chronic (6 mo) CS exposures resulted in a significant decline in the level of locomotor activity and altered the timing of the circadian clock in brain and lung tissues [39].…”

Section: Resultsmentioning

confidence: 99%

Serotonin and Corticosterone Rhythms in Mice Exposed to Cigarette Smoke and in Patients with COPD: Implication for COPD-Associated Neuropathogenesis

et al. 2014

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The circadian timing system controls daily rhythms of physiology and behavior, and disruption of clock function can trigger stressful life events. Daily exposure to cigarette smoke (CS) can lead to alteration in diverse biological and physiological processes. Smoking is associated with mood disorders, including depression and anxiety. Patients with chronic obstructive pulmonary disease (COPD) have abnormal circadian rhythms, reflected by daily changes in respiratory symptoms and lung function. Corticosterone (CORT) is an adrenal steroid that plays a considerable role in stress and anti-inflammatory responses. Serotonin (5-hydroxytryptamine; 5HT) is a neurohormone, which plays a role in sleep/wake regulation and affective disorders. Secretion of stress hormones (CORT and 5HT) is under the control of the circadian clock in the suprachiasmatic nucleus. Since smoking is a contributing factor in the development of COPD, we hypothesize that CS can affect circadian rhythms of CORT and 5HT secretion leading to sleep and mood disorders in smokers and patients with COPD. We measured the daily rhythms of plasma CORT and 5HT in mice following acute (3 d), sub-chronic (10 d) or chronic (6 mo) CS exposure and in plasma from non-smokers, smokers and patients with COPD. Acute and chronic CS exposure affected both the timing (peak phase) and amplitude of the daily rhythm of plasma CORT and 5HT in mice. Acute CS appeared to have subtle time-dependent effects on CORT levels but more pronounced effects on 5HT. As compared with CORT, plasma 5HT was slightly elevated in smokers but was reduced in patients with COPD. Thus, the effects of CS on plasma 5HT were consistent between mice and patients with COPD. Together, these data reveal a significant impact of CS exposure on rhythms of stress hormone secretion and subsequent detrimental effects on cognitive function, depression-like behavior, mood/anxiety and sleep quality in smokers and patients with COPD.

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“…Changes in HPA axis activity are associated with numerous pathophysiological conditions, for example persons under chronic stress or with depression have, on average, higher levels of cortisol [5], [6]. In addition, the cortisol awakening response is blunted or even absent in subjects having hippocampal damage, diabetes and hypertension [7], [8].…”

Section: Introductionmentioning

confidence: 99%

Familial Longevity Is Marked by Lower Diurnal Salivary Cortisol Levels: The Leiden Longevity Study

et al. 2012

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BackgroundReported findings are inconsistent whether hypothalamic-pituitary-adrenal (HPA) signaling becomes hyperactive with increasing age, resulting in increasing levels of cortisol. Our previous research strongly suggests that offspring from long-lived families are biologically younger. In this study we assessed whether these offspring have a lower HPA axis activity, as measured by lower levels of cortisol and higher cortisol feedback sensitivity.MethodsSalivary cortisol levels were measured at four time points within the first hour upon awakening and at two time points in the evening in a cohort comprising 149 offspring and 154 partners from the Leiden Longevity Study. A dexamethasone suppression test was performed as a measure of cortisol feedback sensitivity. Age, gender and body mass index, smoking and disease history (type 2 diabetes and hypertension) were considered as possible confounding factors.ResultsSalivary cortisol secretion was lower in offspring compared to partners in the morning (Area Under the Curve = 15.6 versus 17.1 nmol/L, respectively; p = 0.048) and in the evening (Area Under the Curve = 3.32 versus 3.82 nmol/L, respectively; p = 0.024). Salivary cortisol levels were not different after dexamethasone (0.5 mg) suppression between offspring and partners (4.82 versus 5.26 nmol/L, respectively; p = 0.28).ConclusionOffspring of nonagenarian siblings are marked by a lower HPA axis activity (reflected by lower diurnal salivary cortisol levels), but not by a difference in cortisol feedback sensitivity. Further in-depth studies aimed at characterizing the HPA axis in offspring and partners are needed.

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Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression

Cited by 80 publications

References 45 publications

Regulation of hypothalamic-pituitary-adrenal activity in response to cognitive therapy in patients with generalized anxiety disorder

Regulation of hypothalamic-pituitary-adrenal activity in response to cognitive therapy in patients with generalized anxiety disorder

Serotonin and Corticosterone Rhythms in Mice Exposed to Cigarette Smoke and in Patients with COPD: Implication for COPD-Associated Neuropathogenesis

Familial Longevity Is Marked by Lower Diurnal Salivary Cortisol Levels: The Leiden Longevity Study

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