Correlation between cord blood bilirubin level and incidence of hyperbilirubinemia in term newborns

Satrya, Rudy; Effendi, Sjarif Hidayat; Gumida, Dida Akhmad

doi:10.14238/pi49.6.2009.349-54

Cited by 27 publications

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“…The mean total cord bilirubin at birth and TCB at 72 hours of age, had no statistically significant relation to gender and the type of delivery, and consistent with the results of some studies (10,15,17,18). Two studies (19,20) found that UCSB level was significantly different between the sexes. We assume that the difference may be the result of G6PD enzyme deficiency among males as it is an X-linked recessive disorder that was excluded from our study, and they did not exclude these types of babies.…”

Section: Discussionsupporting

confidence: 86%

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Are Cord Blood Bilirubin Values Trustable to Predict the Forthcoming Significant Hyperbilirubinemia Requiring Treatment in Healthy Term Newborns?

et al. 2019

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Background: Jaundice is a clinical condition that is often observed in pediatric practice and constitutes one of the major issues within the neonatal period. As severe jaundice causes neurotoxicity (kernicterus), the diagnosis and treatment of severe hyperbilirubinemia is very important. Early prediction will help in early discharge and will prevent hospitalization of babies and mothers. On the other hand, predicting outcome in high risk neonates for subsequent hyperbilirubinemia is required. Objectives: This study investigates the predictive value of umbilical cord serum bilirubin (UCSB) for subsequent hyperbilirubinemia which is a required treatment in healthy term newborns. Methods: In this prospective study, 238 healthy term newborns were inducted into the study. Soon after delivery, the cord blood was sent for serum bilirubin analysis. Newborns were followed up by TCB (transcutaneous bilirubinometry) until the third day post birth and those who showed significantly high TCB values, according to the hour-specific normogram, received the appropriate intervention and treatment. The data were analyzed using t-Test, ROC (receiver operating characteristic) curve, and chi-square tests.Results: Of 238 newborns, 27 (11.4%) cases developed hyperbilirubinemia (bilirubin ≥ 15 mg/dL), which required phototherapy.There were no significant differences between the cases who did and who did not develop hyperbilirubinemia (bilirubin < 15 mg/dL) with respect to various factors that might be associated with the risk of hyperbilirubinemia such as mode of delivery and gender. However, two groups were significantly different in terms of cord bilirubin levels. ROC (receiver operating characteristic) analysis showed that the critical value of umbilical cord serum bilirubin (UCSB) ≥ 2.25 mg/dl had high sensitivity (92.6%), good positive and negative predictive value (66% and 69% respectively).Conclusions: UCSB level ≥ 2.25 mg/dL can be a useful predictor of hyperbilirubinemia in healthy term newborns on the third day. Therefore, infants with UCSB level ≥ 2.25 mg/dL should be followed up strictly either in a hospital or in an outpatient department on the third day, whereas neonates with cord bilirubin level < 2.25 mg/dL are probably safe for early discharge.

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Section: Discussionsupporting

confidence: 86%

“…25 mg/dL, this is in line with other studies(6,15). Satrya et al(19) showed that UCSB level > 2.54 had high specificity and sensitivity. Zeitoun et al(15) also found that UCSB level > 2.15 mg/dL had the highest sensitivity and at this critical cord bilirubin level, negative predictive value was very high.…”

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confidence: 87%

Are Cord Blood Bilirubin Values Trustable to Predict the Forthcoming Significant Hyperbilirubinemia Requiring Treatment in Healthy Term Newborns?

et al. 2019

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“…However, studies done by Satrya and Maisels and Kring had showed that male babies are at a higher risk of developing icterus and subsequent intervention for icterus. 11,12 But the presentation study is in correlation with study done by Taksande et al which states that there is no relation between neonatal hyperbilirubinemia and the sex of the baby. 5 In this study, it was noted that the gestational age at which the baby was born had a positive correlation with the presence lower albumin levels.…”

Section: Figure 1: Association Between Cord Albumin Level and Neonatamentioning

confidence: 50%

Cord blood albumin as a predictor of neonatal hyperbilirubinemia in healthy neonates

Aiyappa

Shriyan

Raj

2017

Int J Contemp Pediatr

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Background: Neonatal jaundice or icterus neonatrum has been observed in newborn babies for many centuries. The objective of this study was to determine the correlation between cord albumin levels and development of hyperbilirubinemia in term healthy neonates.Methods: A prospective study was conducted on 165 term healthy neonates. Gender, gestational age, anthropometric measurements were taken into consideration. It was ascertained that there was no other risk factor for hyperbilirubinemia amongst the neonates. The neonates were divided into two groups A and B based on the cord albumin levels of <2.8 gm/dl and >2.8 gm/dl.Results: Of the 165 babies included in the study, 126 babies were under Group 1 and 39 under Group 2. 44 babies (34%) in group 1 and 28 babies (71.7%) in group 2 (p<0.0005) developed clinical icterus of which 16 in group 1 and 19 in group 2 required phototherapy (p<0.05). 1 baby in group required exchange transfusion. The sensitivity and specificity of cord albumin in detecting neonatal hyperbilirubinemia in this study was determined to be 71.8% and 65.1% respectively.Conclusions: Cord albumin levels help to determine and predict the possibility of hyperbilirubinemia among neonates. Hence this can help to identify the at-risk neonates. So, routine determination of cord albumin can be advocated to keep a track on at risk neonates.

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“…Neonates with serum bilirubin <2mg/dl have low risk for neonatal hyperbilirubinemia, thus can be kept in low priority as compared to neonates with cord blood serum bilirubin >3mg/dl. Neonates with Cord Blood Bilirubin level ≥3mg/dl should be followed more frequently to reduce morbidity and mortality due to neonatal hyperbilirubinemia [13][14][15][16].…”

Section: Resultsmentioning

confidence: 99%

Correlation of Cord Blood Bilirubin Values with Neonatal Jaundice in Health New-Borns: A Prospective Observational Study

Bhat¹

2018

PNBOA

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Objective: The present study was conducted to investigate the predictability of pathological jaundice on cord blood bilirubin values. Methodology: It was a prospective observation study conducted in Kurji holy family hospital on 289 healthy new-borns. Babies were divided into two groups. Group A who developed Physiological Jaundice and Group B who developed pathological jaundice. Cord blood bilirubin was estimated in all newborn who were then followed up-to 5 th day of life. Babies who developed jaundice requiring treatment were admitted in NICU for phototherapy. Rest where checked regularly up-to 5 th day of life and value recorded on 5 th day by estimation of serum bilirubin. Results: Incidence of pathological hyperbilirubinemia in our study was 11.2%. Statistically significant correlation between cord blood bilirubin and development of pathological jaundice. Gender, age, mode of delivery and birth weight has no correlation with cord bilirubin and the subsequent development of jaundice. Cord blood bilirubin <2.5mg/dl when compared with subsequent development of jaundice has high specificity (83.92%) and negative predictive value (87.35 %). Cord blood value of >3.5mg/dl has high sensitivity (97.06%), specificity (99.22%), Positive predictive value (94.29%) and negative predictive value (99.61 %) in predicting future development of future pathological jaundice. Conclusion: 87.35% negative Predictive Value in the present study suggests that in Healthy Term babies (Cord Blood Bilirubin ≤2.5mg/dl) cord serum bilirubin can help to identify those new-borns who are unlikely to require further evaluation and intervention. These new-borns can be discharged with assurance to Parents. Babies with CBB level ≥3mg/dl should be followed more frequently. Thus, this study concludes that cord blood total bilirubin levels reliably predict the occurrence of pathological hyperbilirubinemia.

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Correlation between cord blood bilirubin level and incidence of hyperbilirubinemia in term newborns

Cited by 27 publications

References 0 publications

Are Cord Blood Bilirubin Values Trustable to Predict the Forthcoming Significant Hyperbilirubinemia Requiring Treatment in Healthy Term Newborns?

Are Cord Blood Bilirubin Values Trustable to Predict the Forthcoming Significant Hyperbilirubinemia Requiring Treatment in Healthy Term Newborns?

Cord blood albumin as a predictor of neonatal hyperbilirubinemia in healthy neonates

Correlation of Cord Blood Bilirubin Values with Neonatal Jaundice in Health New-Borns: A Prospective Observational Study

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