Correlation between copy number of mitochondrial DNA and clinico‐pathologic parameters of hepatocellular carcinoma

Yamada, Shinichiro; Nomoto, Shuji; Fujii, Tomohiko; Kaneko, Tetsuya; Takeda, Shin; Inoue, Soichiro; Kanazumi, Naohito; Nakao, Akimasa

doi:10.1016/j.ejso.2006.01.002

Cited by 120 publications

(84 citation statements)

References 22 publications

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“…Numerous studies have revealed that the change of mtDNA copy number is correlated with tumor progression (6,22). In this study, the relative mtDNA copy number was measured by real-time quantitative PCR and the relative mtDNA copy numbers were found to be significantly increased in colon and rectal tumor tissues compared to corresponding non-cancerous ones.…”

Section: A B Cmentioning

confidence: 94%

“…Numerous reports have indicated that the copy number of mtDNA changes in various types of cancer (6)(7)(8)(9)(10)(11)17). In 1989, Yamamoto et al first reported the increased mitochondrial genomic expression in pre-malignant lesions of the colon in patients with pre-cancerous familial polyposis coli (18).…”

Section: A B Cmentioning

confidence: 99%

“…Subsequently, alterations in mtDNA copy number have been observed in a variety of human cancers. The copy number is reduced in hepatocellular and renal cell carcinomas and breast cancer (6)(7)(8). However, it is increased in head and neck and ovarian cancers and esophageal squamous cell carcinomas (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Correlation between increased copy number of mitochondrial DNA and clinicopathological stage in colorectal cancer

Yang¹

2011

Oncol Lett

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Abstract. Change of mitochondrial DNA (mtDNA) copy numbers is considered to be an important hallmark of cancers. However, whether quantitative changes in mtDNA occur during the initiation and progression of colorectal cancer remains to be determined. Quantitative change in mtDNA was observed during the initiation and progression of colorectal cancer and possible correlations of the mtDNA copy number in colorectal cancer with the clinicopathological stage were investigated. Tumor tissues and the corresponding noncancerous tissues were surgically resected from 24 colon and 20 rectal patients between 2008 and 2009. β-actin expression was quantified in all of the specimens, and the copy numbers were calculated. In colorectal cancer, the quantitative changes of mtDNA exhibited a significant increase. In 24 cases of colon cancer, the average relative mtDNA copy number ratios were 115.15±31.57 in cancer tissues and 54.09±13.22 in the corresponding non-cancerous tissues (p<0.01). Furthermore, in 20 cases of rectal cancer, the ratios were 145.6±43.83 in cancer tissues and 55.58±12.47 in the corresponding non-cancerous tissues (p<0.001). Following correlation with clinicopathological data, change of the mtDNA copy number in colorectal cancer exhibited a significant association with clinicopathological stage, but no association with gender. Moreover, this increase was particularly marked in stages Ⅰ and Ⅱ. Our results indicate that mtDNA copy number plays a significant role during the initiation and progression of colorectal cancer, particularly during early clinicopathological stages.

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Section: A B Cmentioning

confidence: 94%

Section: A B Cmentioning

confidence: 99%

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Correlation between increased copy number of mitochondrial DNA and clinicopathological stage in colorectal cancer

Yang¹

2011

Oncol Lett

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“…다 [12,16,17]. 하지만 아직까지 미토콘드리아의 다형성 과 복제수의 관계는 암세포뿐 아니라 정상 세포에서도 연구가 되어 있지 않아서, 이들 관계의 질환에서의 의의 를 비교해볼 수 있는 대조군이 없는 현실이다.…”

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Association between Mitochondrial D-loop Polymorphism and Copy Number

Lee

Kim

2014

Korean J Phys Anthropol

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“…Among the problems faced by researchers, are the distinct susceptibilities of HCC worldwide (Kew, 2002;El-Serag and Rudolph, 2007), the dissimilar responses to common therapies between individuals (Worns and Galle, 2010), and the diverse survival and recurrence rates in different populations (Artinyan et al, 2010). This diversity is partially due to human genetic variations such as mutations, polymorphisms, and mtDNA copy number (Wong et al, 2000;Sheen et al, 2003;Lee et al, 2004;Kirk et al, 2005;Yamada et al, 2006;Wu et al, 2007). In the past several decades, since the association between human genetic variations and HCC was initially investigated, there has been a lack of an integrated database.…”

Section: Introductionmentioning

confidence: 99%

dbHCCvar: A comprehensive database of human genetic variations in hepatocellular carcinoma

Fang

Tang

et al. 2011

Hum. Mutat.

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Hepatocellular carcinoma is a common cancer with a high mortality rate. The complete pathogenesis of hepatocellular carcinoma is not completely understood, and highly efficient therapy is still unavailable. In the past several decades, various genetic variations such as mutations and polymorphisms have been reported to be associated with hepatocellular carcinoma risk, progression, survival, and recurrence. However, to our knowledge, these genetic variations have not been comprehensively and systematically compiled. In this study we constructed dbHCCvar, a free online database of human genetic variations in hepatocellular carcinoma. Eligible publications were collected from PubMed, and detailed information and major research data from each eligible study were then extracted and recorded in our database. As a result, dbHCCvar contains almost all human genetic variations reported to be associated or not associated with hepatocellular carcinoma risk, clinical pathology, drug reaction, survival, or recurrence to date. It is expected that dbHCCvar will function as a useful tool for researchers to facilitate the search and identification of new genetic markers for hepatocellular carcinoma. dbHCCvar is free for all visitors at

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Correlation between copy number of mitochondrial DNA and clinico‐pathologic parameters of hepatocellular carcinoma

Cited by 120 publications

References 22 publications

Correlation between increased copy number of mitochondrial DNA and clinicopathological stage in colorectal cancer

Correlation between increased copy number of mitochondrial DNA and clinicopathological stage in colorectal cancer

Association between Mitochondrial D-loop Polymorphism and Copy Number

dbHCCvar: A comprehensive database of human genetic variations in hepatocellular carcinoma

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