Correlation Between Contrast Enhancement in Dynamic Magnetic Resonance Imaging of the Breast and Tumor Angiogenesis

Frouge, C.; Jm, Guinebretière; Contesso, G.; R, Di Paola; Bléry, M

doi:10.1097/00004424-199412000-00006

Cited by 121 publications

(71 citation statements)

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“…Malignant tumors of the breast often show an in creased capillary network with increased permeabili- ty, factors which contribute to the earlier and stronger contrast enhancement in breast malignan cies [14]. In our series, of 145 histologically confirmed malig nant tumors, 6 (4%) could not be recognized on gado linium-enhanced MR imaging, because no abnormal en hancement was seen (Table 1).…”

Section: Discussionmentioning

confidence: 59%

False-negative MR imaging of malignant breast tumors

et al. 1997

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Abstract. In this study we analyze MR-negative ma lignant lesions of the breast. A total of 204 patients with palpable and/or mammographie lesions were studied. The MR technique consisted of the turbo FLASH and MP-RAGE subtraction techniques. All patients underwent surgical biopsy and/or mastecto my and all specimens were examined by the correla tive radiologic-histologic mapping technique, A total of 208 lesions were evaluated; 145 turned out to be malignant and 63 proved to be benign. Six malignant lesions were misinterpreted as benign on MR imag ing; thus, suspicious contrast enhancement was pre sent in 96 % of the lesions detected by mammogra phy, US, or clinical examination. Especially 4 of the 17 ductal carcinoma in situ (DCIS) lesions were mis interpreted (23.5 %). Despite optimal technique, 6 malignant lesions were not identified by MR imaging. The highest prevalence of these MR occult lesions was in the group of DCIS. Although MR imaging has an important role in the evaluation of breast le sions and, primarily, in ruling out malignancy, one should be aware of the fact that false-negative MR findings do occur.

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Section: Discussionmentioning

confidence: 59%

False-negative MR imaging of malignant breast tumors

et al. 1997

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“…The correlation between enhanced effect in dynamic CT and MVD has been reported in lung cancer, 33 hepatic cellular carcinoma, 34 pancreatic ductal adenocarcinoma, 35 prostate disease, 36 and mammary adenocarcinoma. 37,38 Moreover, one study showed that MVD decrease is a predictive factor of prognosis, and MVD has significant negative correlation with Ki67 index in PNEN. 22 In that study, Marion-Audibert et al showed that well-differentiated neuroendocrine neoplasms can induce the maintenance of organoid features in their microenvironment, including a high microvascular density recalling the situation in the normal pancreatic neuroendocrine tissue.…”

Section: Discussionmentioning

confidence: 99%

Dynamic computed tomography is useful for prediction of pathological grade in pancreatic neuroendocrine neoplasm

Horiguchi

Kato

Shiraha

et al. 2017

J of Gastro and Hepatol

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“…In fact, nonmalignant angiogenesis can occur in benign tumors (eg, fibroadenomas) or premalignant lesions. 13 Furthermore, echo-enhancing agents exaggerate high vascularity in benign lesions, an effect that can mimic the characteristics of malignant neovascularity and thus increase the likelihood of false-positive findings of malignancy in cases of benign tumors on contrast-enhanced PDUS. In our study, this effect resulted in a higher sensitivity but a lower specificity for contrast-enhanced PDUS than for PDUS without contrast enhancement.…”

Section: Discussionmentioning

confidence: 99%

Value of contrast‐enhanced power Doppler sonography using a microbubble echo‐enhancing agent in evaluation of small breast lesions

Kook¹,

Kwag²

2003

J of Clinical Ultrasound

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Compared with PDUS without contrast enhancement, contrast-enhanced PDUS provides better visualization of the morphology of vascular Doppler signals that is characteristic of malignancy and therefore has a higher sensitivity and diagnostic accuracy, albeit a lower specificity. In differentiating between benign and malignant small breast lesions, contrast-enhanced PDUS can be helpful when used with gray-scale sonography and PDUS without contrast enhancement.

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Correlation Between Contrast Enhancement in Dynamic Magnetic Resonance Imaging of the Breast and Tumor Angiogenesis

Cited by 121 publications

References 0 publications

False-negative MR imaging of malignant breast tumors

False-negative MR imaging of malignant breast tumors

Dynamic computed tomography is useful for prediction of pathological grade in pancreatic neuroendocrine neoplasm

Value of contrast‐enhanced power Doppler sonography using a microbubble echo‐enhancing agent in evaluation of small breast lesions

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