Correlation between cognitive deficits and dorsolateral prefrontal cortex functional connectivity in first-episode depression

Zhang, Xuemei; Zhang, Rongrong; Lv, Lanlan; Qi, Xinyang; Shi, Jingping; Xie, Shusen

doi:10.1016/j.jad.2022.06.024

Cited by 23 publications

(16 citation statements)

References 55 publications

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“…Using RBANS, we found there were no significant differences in cognitive function among patients with depressive disorders compared to the controls, which is in contrast to the findings of previous studies[ 45 - 47 ]. The large discrepancy may be attributed to the following reasons.…”

Section: Discussioncontrasting

confidence: 99%

Abnormalities of electroencephalography microstates in patients with depression and their association with cognitive function

Peng,

Fan,

et al. 2024

World J Psychiatry

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BACKGROUND A growing number of recent studies have explored underlying activity in the brain by measuring electroencephalography (EEG) in people with depression. However, the consistency of findings on EEG microstates in patients with depression is poor, and few studies have reported the relationship between EEG microstates, cognitive scales, and depression severity scales. AIM To investigate the EEG microstate characteristics of patients with depression and their association with cognitive functions. METHODS A total of 24 patients diagnosed with depression and 32 healthy controls were included in this study using the Structured Clinical Interview for Disease for The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. We collected information relating to demographic and clinical characteristics, as well as data from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS; Chinese version) and EEG. RESULTS Compared with the controls, the duration, occurrence, and contribution of microstate C were significantly higher [depression (DEP): Duration 84.58 ± 24.35, occurrence 3.72 ± 0.56, contribution 30.39 ± 8.59; CON: Duration 72.77 ± 10.23, occurrence 3.41 ± 0.36, contribution 24.46 ± 4.66; Duration F = 6.02, P = 0.049; Occurrence F = 6.19, P = 0.049; Contribution F = 10.82, P = 0.011] while the duration, occurrence, and contribution of microstate D were significantly lower (DEP: Duration 70.00 ± 15.92, occurrence 3.18 ± 0.71, contribution 22.48 ± 8.12; CON: Duration 85.46 ± 10.23, occurrence 3.54 ± 0.41, contribution 28.25 ± 5.85; Duration F = 19.18, P < 0.001; Occurrence F = 5.79, P = 0.050; Contribution F = 9.41, P = 0.013) in patients with depression. A positive correlation was observed between the visuospatial/constructional scores of the RBANS scale and the transition probability of microstate class C to B (r = 0.405, P = 0.049). CONCLUSION EEG microstate, especially C and D, is a possible biomarker in depression. Patients with depression had a more frequent transition from microstate C to B, which may relate to more negative rumination and visual processing.

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Section: Discussioncontrasting

confidence: 99%

Abnormalities of electroencephalography microstates in patients with depression and their association with cognitive function

Peng,

Fan,

et al. 2024

World J Psychiatry

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“…The anterior cingulate cortex and the precuneus have been reported to play important roles in the pathophysiology of MDD, although with poor reproducibility of results (Connolly et al, 2013 ; Lai, 2018 ; Zheng et al, 2018 ). For STS2, strengths of the connectivities between dlPFC and DMN were significantly increased in patients, similar to previous results (Ye et al, 2012 ; Zhang et al, 2022 ). Notably, there were also a few altered connections between the dlPFC and other regions (superior temporal gyrus in the ventral attention network, inferior occipital gyrus in the visual network, and bilateral superior temporal gyrus in the auditory network); which demonstrated widespread alterations of dlPFC connectivity in patients’ dynamic functional patterns.…”

Section: Discussionsupporting

confidence: 91%

“…Small datasets, heterogeneous clinical presentations, and evaluations during both initial and recurrent episodes have confounded the replication of results regarding changes of whole brain networks in patients with MDD. Recently, a few studies obtained significant results about FEDN MDD (Wu et al, 2016 ; Yang et al, 2018 ; Zhang et al, 2022 ). The excessive temporal variations of brain FC reflecting abnormal communications between large-scale brain networks over time were present in FEDN MDD (Long et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Altered spatio-temporal state patterns for functional dynamics estimation in first-episode drug-naive major depression

Jing

Huo

et al. 2022

Brain Imaging and Behavior

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Patients with major depressive disorder (MDD) display affective and cognitive impairments. Although MDD-associated abnormalities of brain function and structure have been explored in depth, the relationships between MDD and spatio-temporal large-scale functional networks have not been evaluated in large-sample datasets. We employed data from International Big-Data Center for Depression Research (IBCDR), and comparable 543 healthy controls (HC) and 314 first-episode drug-naive (FEDN) MDD patients were included. We used a multivariate pattern classification method to learn informative spatio-temporal functional states. Brain states of each participant were extracted for functional dynamic estimation using an independent component analysis. Then, a multi-kernel pattern classification method was developed to identify discriminative spatio-temporal states associated with FEDN MDD. Finally, statistical analysis was applied to intrinsic and clinical brain characteristics. Compared with HC, FEDN MDD patients exhibited altered spatio-temporal functional states of the default mode network (DMN), the salience network, a hub network (centered on the dorsolateral prefrontal cortex), and a relatively complex coupling network (visual, DMN, motor-somatosensory and subcortical networks). Multi-kernel classification models to distinguish patients from HC obtained areas under the receiver operating characteristic curves up to 0.80. Classification scores correlated with Hamilton Depression Rating Scale scores and age at MDD onset. FEDN MDD patients had multiple abnormal spatio-temporal functional states. Classification scores derived from these states were related to symptom severity. The assessment of spatio-temporal states may represent a powerful clinical and research tool to distinguish between neuropsychiatric patients and controls. Supplementary Information The online version contains supplementary material available at 10.1007/s11682-022-00739-1.

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“…However, the reason why patients after a stroke episode is more vulnerable to depression is still unknown. First-episode depression patients showed stronger FC in the left thalamus and reduced FC between the SOG.L and left dorsolateral prefrontal cortex seed region (Zhang et al, 2022), which suggest that abnormal connectivity of these functional circuits may be the underlying mechanism of mood disorders in patients with major depression disorder. In this study, we found that the ReHo value in the SOG.L region had altered and was positively associated with HAMD scores, indicating that the SOG.L might be a relevant node of aberrant neural networks in depression, as well as an early involved specific brain region with altered spontaneous brain activity in the vulnerable carotid plaque group.…”

Section: Discussionmentioning

confidence: 96%

Brain alterations of regional homogeneity, degree centrality, and functional connectivity in vulnerable carotid plaque patients with neither clinical symptoms nor routine MRI lesions: A resting-state fMRI study

Wang

Ouyang

et al. 2022

Front. Neurosci.

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AimsBased on resting-state functional MRI (fMRI), we preliminarily explored brain alterations in asymptomatic patients with vulnerable carotid plaques, but carotid stenosis was < 50%.MethodsA total of 58 asymptomatic patients with vulnerable carotid plaques (stenosis <50%) and 38 healthy controls were recruited. Between-group differences in regional homogeneity (ReHo), degree centrality (DC), and functional connectivity (FC) were analyzed. Correlation analysis was performed between the ReHo or DC values in altered brain regions as well as voxel-wise abnormal FC and scores on neuropsychiatric scales, serum interleukin-6 (IL-6), and C-reactive protein (CRP).ResultsBoth ReHo and DC values on the left superior occipital gyrus (SOG.L) of the asymptomatic vulnerable carotid plaque group reduced, regardless of plaque location (left, right, or bilateral). Functional connections weakened between the SOG.L and right lingual gyrus (LING.R)/right inferior occipital gyrus (IOG.R), right middle frontal gyrus (MFG.R)/orbital part of superior frontal gyrus (ORBsup.R)/orbital part of middle frontal gyrus (ORBmid.R), left precentral gyrus (PreCG.L)/postcentral gyrus (PoCG.L), left supplementary motor area (SMA.L), right paracentral lobule (PCL.R), left precuneus (PCUN.L), and right postcentral gyrus (PoCG.R)/PCL.R. In ReHo-altered brain regions, ReHo values were positively correlated with Hamilton Rating Scale for Depression (HAMD) scores, and the setting region of abnormal ReHo as seed points, voxel-wise FC between the SOG.L and PreCG.L was negatively correlated with CRP.ConclusionsCerebral alterations of neuronal synchronization, activity, and connectivity properties in the asymptomatic vulnerable carotid plaque group were independent of the laterality of vulnerable carotid plaques. Significant relation between ReHo values on the SOG.L and HAMD indicated that even when there were neither clinical symptoms nor lesions on routine MRI, brain function might have changed already at an early stage of carotid atherosclerosis. Inflammation might play a role in linking vulnerable carotid plaques and changes of resting-state functional connectivity.

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Correlation between cognitive deficits and dorsolateral prefrontal cortex functional connectivity in first-episode depression

Cited by 23 publications

References 55 publications

Abnormalities of electroencephalography microstates in patients with depression and their association with cognitive function

Abnormalities of electroencephalography microstates in patients with depression and their association with cognitive function

Altered spatio-temporal state patterns for functional dynamics estimation in first-episode drug-naive major depression

Brain alterations of regional homogeneity, degree centrality, and functional connectivity in vulnerable carotid plaque patients with neither clinical symptoms nor routine MRI lesions: A resting-state fMRI study

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